{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T15:18:48Z","timestamp":1780413528823,"version":"3.54.1"},"reference-count":13,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T00:00:00Z","timestamp":1749600000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>We report a case of a triazole and echinocandin-resistant C. glabrata right shoulder prosthetic joint infection in a 60-year-old woman. The patient underwent surgery and received the novel triterpenoid antifungal agent ibrexafungerp. She initially improved, but relapsed four months post-treatment. This case highlights the potential role of ibrexafungerp in multidrug-resistant Candida infections.<\/jats:p>","DOI":"10.3390\/jof11060442","type":"journal-article","created":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T05:23:16Z","timestamp":1749619396000},"page":"442","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Candida glabrata Prosthetic Joint Infection Managed with Ibrexafungerp"],"prefix":"10.3390","volume":"11","author":[{"given":"Ella","family":"Nadarevic","sequence":"first","affiliation":[{"name":"Division of Public Health, Infectious Diseases, and Occupational Medicine, Mayo Clinic, Rochester, MN 55905, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7507-232X","authenticated-orcid":false,"given":"Jack","family":"McHugh","sequence":"additional","affiliation":[{"name":"Division of Public Health, Infectious Diseases, and Occupational Medicine, Mayo Clinic, Rochester, MN 55905, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6581-3956","authenticated-orcid":false,"given":"Paschalis","family":"Vergidis","sequence":"additional","affiliation":[{"name":"Division of Public Health, Infectious Diseases, and Occupational Medicine, Mayo Clinic, Rochester, MN 55905, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1093\/infdis\/jiaa502","article-title":"Invasive Candidiasis Species Distribution and Trends, United States, 2009\u20132017","volume":"223","author":"Ricotta","year":"2021","journal-title":"J. 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Clin."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"3056","DOI":"10.1093\/jac\/dkz277","article-title":"MSG-10: A Phase 2 study of oral ibrexafungerp (SCY-078) following initial echinocandin therapy in non-neutropenic patients with invasive candidiasis","volume":"74","author":"Spec","year":"2019","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_6","unstructured":"U.S. Food and Drug Administration (2024, December 11). BREXAFEMME\u00ae (ibrexafungerp). SCYNEXIS Inc., Available online: https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2022\/214900s002lbl.pdf."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e1-140.e4","DOI":"10.1016\/j.cmi.2021.09.030","article-title":"In vitro activity of ibrexafungerp against Candida species isolated from blood cultures. Determination of wild-type populations using the EUCAST method","volume":"28","author":"Mesquida","year":"2022","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_8","unstructured":"Cornely, O.A., Alexander, B.D., Pappas, P., Patterson, T.F., Hoenigl, M., Miceli, M.H., Vergidis, P., Spec, A., Thompson, G.R., and Ostrosky-Zeichner, L. (2025, January 11\u201315). An Open-label Study of Ibrexafungerp in Patients with Refractory Fungal Infections (FURI). Proceedings of the ESCMID Global, Vienna, Austria."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1001\/archinte.169.4.379","article-title":"Risk factors for fluconazole-resistant Candida glabrata bloodstream infections","volume":"169","author":"Lee","year":"2009","journal-title":"Arch. Intern. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"3417","DOI":"10.1128\/AAC.06100-11","article-title":"Recurrent episodes of candidemia due to Candida glabrata with a mutation in hot spot 1 of the FKS2 gene developed after prolonged therapy with caspofungin","volume":"56","author":"Gago","year":"2012","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e01692-19","DOI":"10.1128\/AAC.01692-19","article-title":"In Vitro Activity of Ibrexafungerp, a Novel Glucan Synthase Inhibitor against Candida glabrata Isolates with FKS Mutations","volume":"63","author":"Nunnally","year":"2019","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e0216","DOI":"10.1097\/HC9.0000000000000216","article-title":"Invasive fungal infections in liver diseases","volume":"7","author":"Barros","year":"2023","journal-title":"Hepatol. Commun."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1086\/596757","article-title":"Infectious Diseases Society of America. Clinical practice guidelines for the management of candidiasis: 2009 update by the Infectious Diseases Society of America","volume":"48","author":"Pappas","year":"2009","journal-title":"Clin. 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