{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:36:35Z","timestamp":1787726195610,"version":"build-2784847793"},"reference-count":25,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T00:00:00Z","timestamp":1753747200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>Introduction\/objectives: Peritonitis resulting from Candida spp. is common among critically ill patients and has been associated with adverse clinical outcomes. This study aimed to determine the effects of isolates of Candida species in patients with peritonitis on in-hospital mortality, general hospital stay, and intensive care unit (ICU) stays. Methods: This retrospective cohort study was conducted in two highly complex hospitals in Bogot\u00e1, Colombia, specifically by reference to patients who were hospitalized in the ICU between 2016 and 2022 with a clinical and microbiological diagnosis of peritonitis. For the analysis conducted for this research, two groups were established: patients with isolates of Candida spp. in the peritoneum and patients who had at least one bacterial microorganism in the culture. Multivariate logistic regression models and counting models featuring different mortality outcomes, different lengths of stay in the ICU, and different lengths of stay in the hospital were generated to evaluate the effect of the presence of Candida spp. and to account for potentially confounding variables. Results: A total of 373 patients, including 83 with Candida spp. and 290 with a bacterial etiology, were identified. Among the former group of patients, the most frequently identified species were C. albicans (50, 60.2%), C. tropicalis (18, 21.7%), and C. glabrata (7, 8.4%), whereas among the latter group, E. coli (186, 48.5%), K. pneumoniae (110, 29.8%), and E. faecalis (63, 16.9%) were most frequent. The 30-day mortality rate among patients with peritonitis and Candida isolates was 36.1%, and the corresponding rate among patients in the bacterial peritonitis group was 31.4% (p = 0.071). After adjustments were made to account for covariates, no significant differences were observed in mortality at 30 days (OR 0.75, 95% CI 0.20\u20131.18), length of hospital stay (iRR 1.11, 95% CI 0.90\u20131.40), or length of stay in the ICU (iRR 1.11, 95% CI 0.39) with respect to patients with peritonitis without fungal isolates. The Simplified Acute Physiology Score (SAPS2) (OR 1.04, 95% CI 1.03\u20131.06), World Society of Emergency Surgery (WSES) score (OR 1.11, (1.03\u20131.19), previous use of antifungals (OR 2.33, 1.21\u20134.52), and connective tissue disease (OR 3.71, 95% CI 1.30\u201310.99) were associated with 30-day mortality. Conclusions: The isolation of Candida species in peritoneal fluid from critically ill patients with peritonitis was not significantly associated with in-hospital mortality, length of hospital stay, or length of ICU stay after adjustments were made to account for other variables.<\/jats:p>","DOI":"10.3390\/jof11080562","type":"journal-article","created":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T10:25:34Z","timestamp":1753784734000},"page":"562","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical Outcomes of Critically Ill Patients with Candida spp. Peritonitis: A Retrospective Cohort Study"],"prefix":"10.3390","volume":"11","author":[{"given":"Gustavo Adolfo","family":"Gonz\u00e1lez-Gonz\u00e1lez","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, Universidad Nacional de Colombia, Bogot\u00e1 111321, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Cristina","family":"Nocua-B\u00e1ez","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, Universidad Nacional de Colombia, Bogot\u00e1 111321, Colombia"},{"name":"Infectious Diseases Department, Hospital Universitario Nacional de Colombia, Office of Clinical Research, Campus Santa Rosa, Bogot\u00e1 111321, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sugeich","family":"Melendez-Rhenals","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, Universidad Nacional de Colombia, Bogot\u00e1 111321, Colombia"},{"name":"Infectious Diseases Department, Hospital Universitario Nacional de Colombia, Office of Clinical Research, Campus Santa Rosa, Bogot\u00e1 111321, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6628-8815","authenticated-orcid":false,"given":"Patricia","family":"Reyes","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, Cl\u00ednica Universitaria Colombia, Cl\u00ednica Colsanitas, Bogot\u00e1 110111, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0882-9652","authenticated-orcid":false,"given":"Jorge Alberto","family":"Cort\u00e9s","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, Universidad Nacional de Colombia, Bogot\u00e1 111321, Colombia"},{"name":"Infectious Diseases Department, Hospital Universitario Nacional de Colombia, Office of Clinical Research, Campus Santa Rosa, Bogot\u00e1 111321, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1097\/00003246-200203000-00008","article-title":"Significance of Candida recovered from intraoperative specimens in patients with intra-abdominal perforations","volume":"30","author":"Sandven","year":"2002","journal-title":"Crit. Care Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.eimc.2012.02.003","article-title":"Candidemia and invasive candidiasis in the adult: Clinical forms and treatment","volume":"30","author":"Cervera","year":"2012","journal-title":"Enfermedades Infecc. Y Microbiol. Clin."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2650","DOI":"10.1007\/s00268-011-1305-2","article-title":"Candida peritonitis: An update on the latest research and treatments","volume":"35","author":"Carneiro","year":"2011","journal-title":"World J. Surg."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/1749-7922-7-36","article-title":"Complicated intra-abdominal infections in Europe: A comprehensive review of the CIAO study","volume":"7","author":"Sartelli","year":"2012","journal-title":"World J. Emerg. Surg. WJES"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0732-8893(02)00419-4","article-title":"Candida peritonitis due to peptic ulcer perforation: Incidence rate, risk factors, prognosis and susceptibility to fluconazole and amphotericin B","volume":"44","author":"Lee","year":"2002","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1001\/archsurg.137.12.1341","article-title":"Predictive factors of mortality due to polymicrobial peritonitis with Candida isolation in peritoneal fluid in critically ill patients","volume":"137","author":"Dupont","year":"2002","journal-title":"Arch. Surg."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1097\/01.CCM.0000201889.39443.D2","article-title":"Candida as a risk factor for mortality in peritonitis","volume":"34","author":"Montravers","year":"2006","journal-title":"Crit. Care Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"117.e1","DOI":"10.1016\/j.cmi.2016.10.001","article-title":"Antifungal therapy for patients with proven or suspected Candida peritonitis: Amarcand2, a prospective cohort study in French intensive care units","volume":"23","author":"Montravers","year":"2017","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"88","DOI":"10.36519\/idcm.2025.539","article-title":"Clinical Outcomes and Microbiological Profiles of Patients with Culture-Confirmed Peritonitis","volume":"7","author":"Akkaya","year":"2025","journal-title":"Infect. Dis. Clin. Microbiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e0223092","DOI":"10.1371\/journal.pone.0223092","article-title":"Critically ill patients with community-onset intraabdominal infections: Influence of healthcare exposure on resistance rates and mortality","volume":"14","author":"Maseda","year":"2019","journal-title":"PLoS ONE"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.jmii.2015.07.004","article-title":"Antifungal therapy did not improve outcomes including 30-day all-cause mortality in patients suffering community-acquired perforated peptic ulcer-associated peritonitis with Candida species isolated from their peritoneal fluid","volume":"50","author":"Li","year":"2017","journal-title":"J. Microbiol. Immunol. Infect. = Wei Mian Yu Gan Ran Za Zhi"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1186\/s13054-023-04742-w","article-title":"Pharmacokinetic and pharmacodynamic considerations for antifungal therapy optimisation in the treatment of intra-abdominal candidiasis","volume":"27","author":"Novy","year":"2023","journal-title":"Crit. Care"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1007\/s40121-021-00585-6","article-title":"Risk Factors for Intra-Abdominal Candidiasis in Intensive Care Units: Results from EUCANDICU Study","volume":"11","author":"Bassetti","year":"2022","journal-title":"Infect. Dis. Ther."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1111\/myc.12331","article-title":"Relevance of Candida and other mycoses for morbidity and mortality in severe sepsis and septic shock due to peritonitis","volume":"58","author":"Lichtenstern","year":"2015","journal-title":"Mycoses"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e13807","DOI":"10.1111\/myc.13807","article-title":"Intra-Abdominal Candidiasis in Cancer Patients: A 10-Year Experience in a Middle-Income Country","volume":"67","author":"Arcieri","year":"2024","journal-title":"Mycoses"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1007\/s00268-020-05380-x","article-title":"Appropriate Source Control and Antifungal Therapy are Associated with Improved Survival in Critically Ill Surgical Patients with Intra-abdominal Candidiasis","volume":"44","author":"Yan","year":"2020","journal-title":"World J. Surg."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s13017-021-00387-8","article-title":"WSES\/GAIS\/SIS-E\/WSIS\/AAST global clinical pathways for patients with intra-abdominal infections","volume":"16","author":"Sartelli","year":"2021","journal-title":"World J. Emerg. Surg. WJES"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1093\/cid\/civ933","article-title":"Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of America","volume":"62","author":"Pappas","year":"2016","journal-title":"Clin. Infect. Dis. Off. Publ. Infect. Dis. Soc. Am."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s13613-015-0103-7","article-title":"Systemic antifungal therapy for proven or suspected invasive candidiasis: The AmarCAND 2 study","volume":"6","author":"Leroy","year":"2016","journal-title":"Ann. Intensive Care"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1097\/01.CCM.0000053525.49267.77","article-title":"Can yeast isolation in peritoneal fluid be predicted in intensive care unit patients with peritonitis?","volume":"31","author":"Dupont","year":"2003","journal-title":"Crit. Care Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1111\/j.1469-0691.2010.03360.x","article-title":"A multicentre study of antifungal strategies and outcome of Candida spp. peritonitis in intensive-care units","volume":"17","author":"Montravers","year":"2011","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.riam.2016.02.003","article-title":"EPICO 3.0. Recommendations on invasive candidiasis in patients with complicated intra-abdominal infection and surgical patients with ICU extended stay","volume":"33","author":"Maseda","year":"2016","journal-title":"Rev. Iberoam. Micol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"S106","DOI":"10.1086\/341930","article-title":"Intra-abdominal anaerobic infections: Bacteriology and therapeutic potential of newer antimicrobial carbapenem, fluoroquinolone, and desfluoroquinolone therapeutic agents","volume":"35","author":"Goldstein","year":"2002","journal-title":"Clin. Infect. Dis."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1264\/jsme2.ME2904rh","article-title":"The challenges of studying the anaerobic microbial world","volume":"29","author":"Mori","year":"2014","journal-title":"Microbes Environ."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"R99","DOI":"10.1186\/cc7931","article-title":"Factors associated with septic shock and mortality in generalized peritonitis: Comparison between community-acquired and postoperative peritonitis","volume":"13","author":"Riche","year":"2009","journal-title":"Crit. 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