{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T07:12:05Z","timestamp":1780470725758,"version":"3.54.1"},"reference-count":39,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T00:00:00Z","timestamp":1754611200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>Invasive yeast infections (IYIs) remain a significant cause of morbidity and mortality in patients with hematologic diseases. We retrospectively analyzed 193 IYI episodes among 179 patients admitted to a tertiary hematology hospital (2012\u20132023). Candida species accounted for 91.7% (n = 177), while non-Candida yeasts comprised 8.3% (n = 16). Among invasive candidiasis, non-albicans Candida spp. were predominant, representing 76.8% (136\/177), with C. tropicalis (36.2%, 64\/177) being the most frequently isolated species. Among non-Candida yeasts, Cryptococcus neoformans (n = 10) was the most commonly identified pathogen. The incidence and 42-day mortality rate of IYIs were 0.199 and 0.095 per 1000 patient-days, respectively. The 42-day case-fatality rate remained high at 47.7%. In categorical analysis, age &gt;65 years, corticosteroid use, elevated lactate (&gt;2 mmol\/L), neutropenia (&lt;500\/mm3), vasopressor use, and mechanical ventilation were more common in non-survivors. Primary bloodstream infections were more frequent in non-survivors, whereas catheter-related and abdominal-origin infections were predominant among survivors. Concomitant bacteremia was observed in 32.6% of IYI cases (n = 63), with Enterococcus faecium being the most frequently isolated co-pathogen. Our findings illustrate the evolving epidemiology of IYIs in hematologic patients, marked by the emergence of C. tropicalis as the predominant species, sustained mortality, and frequent bacterial co-infections, collectively reflecting the substantial clinical burden of IYIs.<\/jats:p>","DOI":"10.3390\/jof11080585","type":"journal-article","created":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T09:56:42Z","timestamp":1754647002000},"page":"585","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Epidemiology and Characteristics of Invasive Yeast Infections in Patients with Hematologic Diseases: 12-Year Single-Center Retrospective Cohort Study"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9824-4975","authenticated-orcid":false,"given":"Dong Young","family":"Kim","sequence":"first","affiliation":[{"name":"Vaccine Bio Research Institute, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keon","family":"Oh","sequence":"additional","affiliation":[{"name":"Vaccine Bio Research Institute, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minseung","family":"Song","sequence":"additional","affiliation":[{"name":"Vaccine Bio Research Institute, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyemin","family":"Kweon","sequence":"additional","affiliation":[{"name":"Vaccine Bio Research Institute, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dukhee","family":"Nho","sequence":"additional","affiliation":[{"name":"Vaccine Bio Research Institute, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea"},{"name":"Division of Infectious Diseases, Department of Internal Medicine, Seoul St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea"},{"name":"Catholic Hematology Hospital, The Catholic University of Korea, Seoul 06591, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9593-8856","authenticated-orcid":false,"given":"Hanter","family":"Hong","sequence":"additional","affiliation":[{"name":"Catholic Hematology Hospital, The Catholic University of Korea, Seoul 06591, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raeseok","family":"Lee","sequence":"additional","affiliation":[{"name":"Vaccine Bio Research Institute, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea"},{"name":"Division of Infectious Diseases, Department of Internal Medicine, Seoul St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea"},{"name":"Catholic Hematology Hospital, The Catholic University of Korea, Seoul 06591, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4655-0641","authenticated-orcid":false,"given":"Dong-Gun","family":"Lee","sequence":"additional","affiliation":[{"name":"Vaccine Bio Research Institute, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea"},{"name":"Division of Infectious Diseases, Department of Internal Medicine, Seoul St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea"},{"name":"Catholic Hematology Hospital, The Catholic University of Korea, Seoul 06591, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5392-3405","authenticated-orcid":false,"given":"Sung-Yeon","family":"Cho","sequence":"additional","affiliation":[{"name":"Vaccine Bio Research Institute, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea"},{"name":"Division of Infectious Diseases, Department of Internal Medicine, Seoul St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea"},{"name":"Catholic Hematology Hospital, The Catholic University of Korea, Seoul 06591, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.cmi.2024.01.005","article-title":"Risk factors for invasive fungal infections after haematopoietic stem cell transplantation: A systematic review and meta-analysis","volume":"30","author":"Biyun","year":"2024","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.chest.2021.08.081","article-title":"Risk Factors for Invasive Candida Infection in Critically Ill Patients: A Systematic Review and Meta-analysis","volume":"161","author":"Schlattmann","year":"2022","journal-title":"Chest"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1111\/myc.13205","article-title":"Epidemiology of invasive fungal disease in haematologic patients","volume":"64","author":"Souza","year":"2021","journal-title":"Mycoses"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e428","DOI":"10.1016\/S1473-3099(23)00692-8","article-title":"Global incidence and mortality of severe fungal disease","volume":"24","author":"Denning","year":"2024","journal-title":"Lancet Infect. Dis."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Won, E.J., Choi, M.J., Jeong, S.H., Kim, D., Shin, K.S., Shin, J.H., Kim, Y.R., Kim, H.S., Kim, Y.A., and Uh, Y. (2022). Nationwide Surveillance of Antifungal Resistance of Candida Bloodstream Isolates in South Korean Hospitals: Two Year Report from Kor-GLASS. J. Fungi, 8.","DOI":"10.3390\/jof8100996"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"491.E1","DOI":"10.1016\/j.cmi.2014.12.027","article-title":"Epidemiology and outcome of candidaemia in patients with oncological and haematological malignancies: Results from a population-based surveillance in Spain","volume":"21","author":"Aguado","year":"2015","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Marekovic, I., Plesko, S., Rezo Vranjes, V., Herljevic, Z., Kulis, T., and Jandrlic, M. (2021). Epidemiology of Candidemia: Three-Year Results from a Croatian Tertiary Care Hospital. J. Fungi, 7.","DOI":"10.3390\/jof7040267"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"101","DOI":"10.5045\/br.2022.2022036","article-title":"Advances in prophylaxis and treatment of invasive fungal infections: Perspectives on hematologic diseases","volume":"57","author":"Ahn","year":"2022","journal-title":"Blood Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/epirev\/mxae003","article-title":"A review of the epidemiology of invasive fungal infections in Asian patients with hematological malignancies (2011\u20132021)","volume":"46","author":"Iyadorai","year":"2024","journal-title":"Epidemiol. Rev."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e954","DOI":"10.1016\/j.ijid.2010.04.006","article-title":"Relative frequency of albicans and the various non-albicans Candida spp among candidemia isolates from inpatients in various parts of the world: A systematic review","volume":"14","author":"Falagas","year":"2010","journal-title":"Int. J. Infect. Dis."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"669","DOI":"10.3109\/13693780903410386","article-title":"Multicenter surveillance of species distribution and antifungal susceptibilities of Candida bloodstream isolates in South Korea","volume":"48","author":"Jung","year":"2010","journal-title":"Med. Mycol."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Yu, S.N., Hong, S.I., Park, J.W., Jeon, M.H., and Cho, O.H. (2025). Epidemiology and Clinical Features of Candida Bloodstream Infections: A 10-Year Retrospective Study in a Korean Teaching Hospital. J. Fungi, 11.","DOI":"10.3390\/jof11030217"},{"key":"ref_13","first-page":"1068","article-title":"The epidemiology of fungal infections in patients with hematologic malignancies: The SEIFEM-2004 study","volume":"91","author":"Pagano","year":"2006","journal-title":"Haematologica"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"myae043","DOI":"10.1093\/mmy\/myae043","article-title":"Cryptococcosis-a systematic review to inform the World Health Organization Fungal Priority Pathogens List","volume":"62","author":"Dao","year":"2024","journal-title":"Med. Mycol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/S1473-3099(10)70218-8","article-title":"Emerging opportunistic yeast infections","volume":"11","author":"Miceli","year":"2011","journal-title":"Lancet Infect. Dis."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1093\/cid\/ciz1008","article-title":"Revision and Update of the Consensus Definitions of Invasive Fungal Disease From the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium","volume":"71","author":"Donnelly","year":"2020","journal-title":"Clin. Infect. Dis."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1111\/myc.12081","article-title":"Epidemiology and sites of involvement of invasive fungal infections in patients with haematological malignancies: A 20-year autopsy study","volume":"56","author":"Lewis","year":"2013","journal-title":"Mycoses"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1111\/myc.13236","article-title":"Characteristics of late recurrent candidemia in adult patients","volume":"64","author":"Anttila","year":"2021","journal-title":"Mycoses"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"340","DOI":"10.3947\/ic.2022.0069","article-title":"Bloodstream Infections in Patients with Hematologic Diseases: Causative Organisms and Factors Associated with Resistance","volume":"54","author":"Choi","year":"2022","journal-title":"Infect. Chemother."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1086\/590566","article-title":"Defining responses to therapy and study outcomes in clinical trials of invasive fungal diseases: Mycoses Study Group and European Organization for Research and Treatment of Cancer consensus criteria","volume":"47","author":"Segal","year":"2008","journal-title":"Clin. Infect. Dis."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jinf.2023.05.005","article-title":"Breakthrough invasive fungal infection among patients with haematologic malignancies: A national, prospective, and multicentre study","volume":"87","author":"Ramos","year":"2023","journal-title":"J. Infect."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1111\/myc.12960","article-title":"Defining breakthrough invasive fungal infection\u2013Position paper of the mycoses study group education and research consortium and the European Confederation of Medical Mycology","volume":"62","author":"Cornely","year":"2019","journal-title":"Mycoses"},{"key":"ref_23","first-page":"237","article-title":"Breakthrough invasive fungal diseases during voriconazole treatment for aspergillosis: A 5-year retrospective cohort study","volume":"55","author":"Kim","year":"2017","journal-title":"Med. Mycol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1093\/cid\/ciab105","article-title":"Temporal Trends of Candidemia Incidence Rates and Potential Contributions of Infection Control Initiatives Over 18 Years Within the United States Veterans Health Administration System: A Joinpoint Time-Series Analysis","volume":"73","author":"Suzuki","year":"2021","journal-title":"Clin. Infect. Dis."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1007\/s11046-023-00754-w","article-title":"Epidemiology of Invasive Candidiasis in Patients with Hematologic Malignancy on Antifungal Prophylaxis","volume":"188","author":"McCort","year":"2023","journal-title":"Mycopathologia"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1128\/CMR.00029-06","article-title":"Epidemiology of invasive candidiasis: A persistent public health problem","volume":"20","author":"Pfaller","year":"2007","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"S394","DOI":"10.1093\/cid\/ciaa1523","article-title":"Clinical Characteristics and Outcomes of Breakthrough Candidemia in 71 Hematologic Malignancy Patients and\/or Allogeneic Hematopoietic Stem Cell Transplant Recipients: A Single-center Retrospective Study From China, 2011-2018","volume":"71","author":"Chen","year":"2020","journal-title":"Clin. Infect. Dis."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1086\/368091","article-title":"The changing epidemiology of cryptococcosis: An update from population-based active surveillance in 2 large metropolitan areas, 1992\u20132000","volume":"36","author":"Mirza","year":"2003","journal-title":"Clin. Infect. Dis."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/s41572-024-00503-3","article-title":"Invasive candidiasis","volume":"10","author":"Kanj","year":"2024","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Little, J.S., Weiss, Z.F., and Hammond, S.P. (2021). Invasive Fungal Infections and Targeted Therapies in Hematological Malignancies. J. Fungi, 7.","DOI":"10.3390\/jof7121058"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2967","DOI":"10.1097\/CCM.0b013e31818b3477","article-title":"Treatment-related risk factors for hospital mortality in Candida bloodstream infections","volume":"36","author":"Labelle","year":"2008","journal-title":"Crit. Care Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1007\/s00134-015-3866-2","article-title":"A multicenter multinational study of abdominal candidiasis: Epidemiology, outcomes and predictors of mortality","volume":"41","author":"Bassetti","year":"2015","journal-title":"Intensive Care Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"ofac088","DOI":"10.1093\/ofid\/ofac088","article-title":"Hepatosplenic Candidiasis in Patients With Hematological Malignancies: A 13-Year Retrospective Cohort Study","volume":"9","author":"Boussen","year":"2022","journal-title":"Open Forum Infect. Dis."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Zhong, L., Dong, Z., Liu, F., Li, H., Tang, K., Zheng, C., Wang, L., Zhang, K., Cai, J., and Zhou, H. (2022). Incidence, clinical characteristics, risk factors and outcomes of patients with mixed Candida\/bacterial bloodstream infections: A retrospective study. Ann. Clin. Microbiol. Antimicrob., 21.","DOI":"10.1186\/s12941-022-00538-y"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"e13729","DOI":"10.1111\/myc.13729","article-title":"Epidemiological patterns of candidaemia: A comprehensive analysis over a decade","volume":"67","author":"Ferngren","year":"2024","journal-title":"Mycoses"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1038\/s41579-024-01058-6","article-title":"Enterococcus faecium: Evolution, adaptation, pathogenesis and emerging therapeutics","volume":"22","author":"Wei","year":"2024","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2154548","DOI":"10.1080\/19490976.2022.2154548","article-title":"From intestinal colonization to systemic infections: Candida albicans translocation and dissemination","volume":"14","author":"Sprague","year":"2022","journal-title":"Gut Microbes"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Veerapandian, R., Paudyal, A., Schneider, S.M., Lee, S.T.M., and Vediyappan, G. (2024). A mouse model of immunosuppression facilitates oral Candida albicans biofilms, bacterial dysbiosis and dissemination of infection. Front. Cell. Infect. Microbiol., 14.","DOI":"10.3389\/fcimb.2024.1467896"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Allison, D.L., Willems, H.M.E., Jayatilake, J., Bruno, V.M., Peters, B.M., and Shirtliff, M.E. (2016). Candida-Bacteria Interactions: Their Impact on Human Disease. Microbiol. Spectr., 4.","DOI":"10.1128\/microbiolspec.VMBF-0030-2016"}],"container-title":["Journal of Fungi"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2309-608X\/11\/8\/585\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:26:02Z","timestamp":1760034362000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2309-608X\/11\/8\/585"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,8]]},"references-count":39,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2025,8]]}},"alternative-id":["jof11080585"],"URL":"https:\/\/doi.org\/10.3390\/jof11080585","relation":{},"ISSN":["2309-608X"],"issn-type":[{"value":"2309-608X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,8]]}}}