{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T21:19:21Z","timestamp":1778793561775,"version":"3.51.4"},"reference-count":45,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:00:00Z","timestamp":1761868800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Construction of Disciplinary Connotations at Fujian Agriculture and Forestry University","award":["114\/725025010"],"award-info":[{"award-number":["114\/725025010"]}]},{"name":"Fujian Provincial Department of Agriculture and Rural Affairs Min Nong Ke Jiao","award":["[2024] No. 20"],"award-info":[{"award-number":["[2024] No. 20"]}]},{"DOI":"10.13039\/501100016107","name":"Science and Technology Department of Tibet","doi-asserted-by":"publisher","award":["XZ202301ZY0013N"],"award-info":[{"award-number":["XZ202301ZY0013N"]}],"id":[{"id":"10.13039\/501100016107","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016107","name":"Science and Technology Department of Tibet","doi-asserted-by":"publisher","award":["XZ202001ZY0041N"],"award-info":[{"award-number":["XZ202001ZY0041N"]}],"id":[{"id":"10.13039\/501100016107","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>Hericium coralloides is a valuable medicinal and edible mushroom renowned for its unique bioactive compounds. This study focuses on the isolation of a wild strain (SH001) exhibiting promising cultivation potential and health promoting properties. A wild fungal strain from the Tibetan Plateau was isolated and identified as a novel H. coralloides based on its morphological and molecular characteristics. The optimal growth conditions were found to be 30 \u00b0C, pH 7.0, fructose as the preferred carbon source, and yeast extract as the optimal nitrogen source. Nutritional analysis revealed that the fruiting bodies were rich in protein (15.4 g\/100 g dry weight), dietary fiber (34.7 g\/100 g dry weight), and minerals, while being low in fat (3.5 g\/100 g dry weight). The most abundant amino acids were glutamic acid, followed by aspartic acid. The polysaccharides exhibited significant antioxidant activity, with ABTS+ scavenging comparable to that of Vitamin C (Vc), achieving a clearance rate of 96.95% at concentrations between 0.25\u20135.00 mg\/mL. At a concentration of 5 mg\/mL, the DPPH and OH radical scavenging activities reached their peak (83.77% and 67.31%, respectively), along with the highest iron ion reducing capacity (FRAP value: 4.43 mmol\/L. Polysaccharides also exhibited notable anticancer activity, inhibiting HepG2 liver cancer cells and MDA-MB-468 breast cancer cells, with IC50 values of 3.896 mg\/mL and 2.561 mg\/mL, respectively. This study demonstrates that wild H. coralloides can be successfully cultivated in vitro. In conclusion, the fruiting bodies possess substantial nutritional value, and the polysaccharides extracted from them show promising antioxidant and anticancer activities, particularly against HepG2 liver cancer cells and MDA-MB-468 breast cancer cells.<\/jats:p>","DOI":"10.3390\/jof11110785","type":"journal-article","created":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T19:30:27Z","timestamp":1762198227000},"page":"785","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Domestication Cultivation and Nutritional Analysis of Hericium coralloides"],"prefix":"10.3390","volume":"11","author":[{"given":"Yun","family":"Li","sequence":"first","affiliation":[{"name":"College of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiarong","family":"Cai","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaomin","family":"Li","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Hu","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junli","family":"Zhang","sequence":"additional","affiliation":[{"name":"Tibet Academy of Agricultural and Animal Husbandry Sciences, Lhasa 850002, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoping","family":"Wu","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9854-2980","authenticated-orcid":false,"given":"Junsheng","family":"Fu","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,31]]},"reference":[{"key":"ref_1","unstructured":"Li, Y., Li, T.H., Yang, Z.L., Bau, T., and Dai, Y.C. 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