{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T05:41:49Z","timestamp":1791956509774,"version":"4.3.4"},"reference-count":72,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>Since 1997, a laboratory-based survey on cryptococcosis has been conducted in Colombia. We present the results for the period 2017\u20132024. A total of 891 surveys were received. The overall incidence was 0.22 cases per 100,000 people. Among those living with HIV, the incidence was 38, and among HIV-negative people, it was 0.08. Cryptococcosis demonstrated a higher prevalence among men than women (3.2:1). Among patients living with Human Immunodeficiency Virus (HIV), the condition primarily affected younger adults (26\u201340 years). In contrast, among HIV-negative people, it was mostly observed in older adults (\u226560 years). HIV infection was the most significant risk factor (63%), but another cause of immunosuppression was identified in 21.2% cases. Neurocryptococcosis was the most common form of presentation (62.2%), followed by disseminated cryptococcosis (31.1%). The diagnosis was confirmed by culture in 99.4% of patients; the most important sample was cerebrospinal fluid (67.3%), followed by blood (35.4%). Cryptococcus neoformans was identified in 93.1% of cases, and Cryptococcus gatti in 6.9%. Predominant molecular patterns were VNI (92.4%) and VGII (45.3%). The epidemiology of cryptococcosis in Colombia is changing, with a progressive decrease in HIV coinfection and an increase in other immunosuppressive conditions in older people. This study highlights the importance of cryptococcosis in Colombia and the need to report it in order to improve knowledge and thereby promote the quality of diagnosis and the opportunity for more effective treatment.<\/jats:p>","DOI":"10.3390\/jof12010067","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T11:01:14Z","timestamp":1768388474000},"page":"67","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cryptococcosis in Colombia: Analysis of Data from Laboratory-Based Surveillance 2017\u20132024"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4062-147X","authenticated-orcid":false,"given":"Jairo","family":"Lizarazo","sequence":"first","affiliation":[{"name":"Departamento de Medicina Interna, Hospital Universitario Erasmo Meoz, C\u00facuta 540003, Norte de Santander, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9242-3910","authenticated-orcid":false,"given":"Clara In\u00e9s","family":"Agudelo","sequence":"additional","affiliation":[{"name":"Grupo de Microbiolog\u00eda, Instituto Nacional de Salud, Bogot\u00e1 111321, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3029-118X","authenticated-orcid":false,"given":"Patricia","family":"Escand\u00f3n","sequence":"additional","affiliation":[{"name":"Grupo de Microbiolog\u00eda, Instituto Nacional de Salud, Bogot\u00e1 111321, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5970-1598","authenticated-orcid":false,"given":"Elizabeth","family":"Casta\u00f1eda","sequence":"additional","affiliation":[{"name":"Grupo de Microbiolog\u00eda, Instituto Nacional de Salud, Bogot\u00e1 111321, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,14]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2022). WHO Fungal Priority Pathogens List to Guide Research, Development and Public Health Action, World Health Organization."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1016\/S1473-3099(22)00499-6","article-title":"The global burden of HIV-associated cryptococcal infection in adults in 2020: A modelling analysis","volume":"22","author":"Rajasingham","year":"2022","journal-title":"Lancet Infect. Dis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1093\/cid\/cix867","article-title":"Comparative epidemiology and outcomes of Human Immunodeficiency Virus (HIV), non-HIV non-transplant, and solid organ transplant associated Cryptococcosis: A population-based study","volume":"66","author":"George","year":"2018","journal-title":"Clin. Infect. Dis."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"ofad658","DOI":"10.1093\/ofid\/ofad658","article-title":"Cryptococcus neoformans infections differ among Human Immunodeficiency Virus (HIV)-seropositive and HIV-seronegative individuals: Results from a nationwide surveillance program in France","volume":"11","author":"Paccoud","year":"2023","journal-title":"Open Forum Infect. Dis."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e13658","DOI":"10.1111\/myc.13658","article-title":"The prognostic factors for cryptococcal meningitis in non-human immunodeficiency virus patients: An observational study using nationwide database","volume":"67","author":"Namie","year":"2024","journal-title":"Mycoses"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1093\/cid\/ciad321","article-title":"Current epidemiology and clinical features of Cryptococcus infection in patients without Human Immunodeficiency Virus: A multicenter study in 46 hospitals in Australia and New Zealand","volume":"77","author":"Coussement","year":"2023","journal-title":"Clin. Infect. Dis."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Heitman, J., Kozel, T.R., Kyung, J., Kwon-Chung, J.R., and Perfect, A.C. (2011). Environmental niches for Cryptococcus neoformans and Cryptococcus gattii. Cryptococcus: From Human Pathogen to Model Yeast, American Society for Microbiology Press.","DOI":"10.1128\/9781555816858"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1093\/cid\/ciab268","article-title":"MSG07: An international cohort study comparing epidemiology and outcomes of patients with Cryptococcus neoformans or Cryptococcus gattii infections","volume":"73","author":"Baddley","year":"2021","journal-title":"Clin. Infect. Dis."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1093\/mmy\/myz097","article-title":"Clinical insights and epidemiology of central nervous system infection due to Cryptococcus neoformans\/gattii species complexes: A prospective study from South India","volume":"58","author":"Lahiri","year":"2020","journal-title":"Med. Mycol."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Escand\u00f3n, P., Lizarazo, J., Agudelo, C.I., and Casta\u00f1eda, E. (2018). Cryptococcosis in Colombia: Compilation and analysis of data from laboratory-based surveillance. J. Fungi, 4.","DOI":"10.3390\/jof4010032"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s10096-007-0430-1","article-title":"Disseminated cryptococcosis in HIV-uninfected patients","volume":"27","author":"Chuang","year":"2008","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"ref_12","unstructured":"Departamento Administrativo Nacional de Estad\u00edstica (2025, July 05). Available online: https:\/\/www.dane.gov.co\/index.php\/estadisticas-por-tema\/demografia-y-poblacion\/proyecciones-de-poblacion."},{"key":"ref_13","unstructured":"(2005). Cuenta de Alto Costo (CAC), Fondo Colombiano de Enfermedades de Alto Costo. Situaci\u00f3n del VIH en Colombia 2024, Cuenta de Alto Costo."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0123-9392(12)70038-3","article-title":"Protocolo de estudio y manejo de los pacientes con criptococosis","volume":"16","author":"Lizarazo","year":"2012","journal-title":"Infectio"},{"key":"ref_15","first-page":"535","article-title":"Improved diagnostic medium for separation of Cryptococcus neoformans var. neoformans (serotypes A and D) and Cryptococcus neoformans var. gattii (serotypes B and C)","volume":"5","author":"Polacheck","year":"1982","journal-title":"J. Clin. Microbiol."},{"key":"ref_16","unstructured":"(2022). Principles and Procedures for the Development of Epidemiological Cutoff Values for Antifungal Susceptibility Testing (Standard No. CLSI M57S)."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"5898","DOI":"10.1128\/AAC.01115-12","article-title":"Cryptococcus neoformans-Cryptococcus gattii species complex: An international study of wild-type susceptibility endpoint distributions and epidemiological cutoff values for fluconazole, itraconazole, posaconazole, and voriconazole","volume":"56","author":"Aller","year":"2012","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"3107","DOI":"10.1128\/AAC.06252-11","article-title":"Cryptococcus neoformans-Cryptococcus gattii species complex: An international study of wild-type susceptibility endpoint distributions and epidemiological cutoff values for amphotericin B and flucytosine","volume":"56","author":"Chowdhary","year":"2012","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1111\/j.1567-1364.2006.00055.x","article-title":"Molecular epidemiology of clinical and environmental isolates of the Cryptococcus neoformans species complex reveals a high genetic diversity and the presence of the molecular type VGII mating type a in Colombia","volume":"6","author":"Meyer","year":"2006","journal-title":"FEMS Yeast Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/S1567-1356(03)00038-2","article-title":"Molecular typing of clinical and environmental Cryptococcus neoformans isolates in the Brazilian state Rio Grande do Soul","volume":"3","author":"Casali","year":"2003","journal-title":"FEMS Yeast Res."},{"key":"ref_21","unstructured":"Dean, A.G., Sullivan, K.M., and Soe, M.M. (2025, November 20). OpenEpi: Open Source Epidemiologic Statistics for Public Health, Versi\u00f3n 3.01. Available online: www.OpenEpi.com."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"466","DOI":"10.2471\/BLT.22.288269","article-title":"Venezuela: Out of the headlines but still in crisis","volume":"100","author":"Doocy","year":"2022","journal-title":"Bull. World Health Organ."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e428","DOI":"10.1016\/S1473-3099(23)00692-8","article-title":"Global incidence and mortality of severe fungal disease","volume":"24","author":"Denning","year":"2024","journal-title":"Lancet Infect. Dis."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.3201\/eid2007.140087","article-title":"Population-based analysis of invasive fungal infections, France, 2001\u20132010","volume":"20","author":"Bitar","year":"2014","journal-title":"Emerg. Infect. Dis."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.mycmed.2016.11.001","article-title":"LIFE program, the Soci\u00e9t\u00e9 fran\u00e7aise de mycologie m\u00e9dicale SFMM-study group. An estimation of burden of serious fungal infections in France","volume":"26","author":"Gangneux","year":"2016","journal-title":"J. Mycol. Med."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Dos Reis, D.S., de Brito, M.T., Guimar\u00e3es, R.J., and Quaresma, J.A. (2022). Cryptococcosis: Identification of risk areas in the Brazilian Amazon. Microorganisms, 10.","DOI":"10.3390\/microorganisms10071411"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1093\/cid\/ciae066","article-title":"Tracking cryptococcal meningitis to monitor HIV program success during the treat all era: An analysis of national data in Botswana","volume":"79","author":"Milburn","year":"2024","journal-title":"Clin. Infect. Dis."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"myad125","DOI":"10.1093\/mmy\/myad125","article-title":"The incidences and clinical outcomes of cryptococcosis in Taiwan: A nationwide, population-based study, 2002-2015","volume":"62","author":"Guan","year":"2024","journal-title":"Med. Mycol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e437","DOI":"10.1016\/S2214-109X(24)00538-2","article-title":"Prevalence of advanced HIV disease in sub-Saharan Africa: A multi-country analysis of nationally representative household surveys","volume":"13","author":"Stelzle","year":"2025","journal-title":"Lancet Glob. Health"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"114","DOI":"10.4314\/ahs.v20i1.16","article-title":"Magnitude of Cryptococcosis among HIV patients in sub-Saharan Africa countries: A systematic review and meta-analysis","volume":"20","author":"Alemayehu","year":"2020","journal-title":"Afr. Health Sci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1093\/cid\/ciz193","article-title":"A Multicenter, Longitudinal Cohort Study of Cryptococcosis in Human Immunodeficiency Virus-negative people in the United States","volume":"70","author":"Marr","year":"2020","journal-title":"Clin. Infect. Dis."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"myad011","DOI":"10.1093\/mmy\/myad011","article-title":"Characteristics, mortality, associated variables with death, and therapeutic response among HIV-positive, solid organ transplant (SOT), and non-HIV-positive\/non-transplant (NHNT) patients with cryptococcosis: First multicenter cohort study in Brazil","volume":"61","author":"Vidal","year":"2023","journal-title":"Med. Mycol."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Kajeekul, R., Mekawichai, P., and Chayakulkeeree, M. (2023). Clinical features of Cryptococcal meningoencephalitis in HIV-positive and -negative patients in a resource-limited setting. J. Fungi, 9.","DOI":"10.3390\/jof9090869"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Xu, X., Su, X., Li, W., Xu, L., Li, D., Dai, K., Liu, J., and Peng, F. (2025). Clinical features and mortality risk factors in non-HIV elderly patients with cryptococcal meningitis: A retrospective cohort study from 2013 to 2022. PLoS Negl. Trop. Dis., 19.","DOI":"10.1371\/journal.pntd.0013521"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Teekaput, C., Yasri, S., and Chaiwarith, R. (2023). Cryptococcal meningitis: Differences between patients with and without HIV-infection. Pathogens, 12.","DOI":"10.3390\/pathogens12030427"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.riam.2017.04.003","article-title":"Cryptococcosis in an infectious diseases hospital of Buenos Aires, Argentina. Revision of 2041 cases: Diagnosis, clinical features and therapeutics","volume":"35","author":"Arechavala","year":"2018","journal-title":"Rev. Iberoam. Micol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1111\/myc.13440","article-title":"Cryptococcosis in the Democratic Republic of Congo from 1953 to 2021: A systematic review and meta-analysis","volume":"65","author":"Zono","year":"2022","journal-title":"Mycoses"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"myae115","DOI":"10.1093\/mmy\/myae115","article-title":"The evolution of HIV-associated cryptococcal meningitis in Uganda from 2010 to 2022","volume":"63","author":"Walukaga","year":"2024","journal-title":"Med. Mycol."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"McClelland, E.E., Hobbs, L.M., Rivera, J., Casadevall, A., Potts, W.K., Smith, J.M., and Ory, J.J. (2013). The role of host gender in the pathogenesis of Cryptococcus neoformans infections. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0063632"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/j.cmi.2024.03.031","article-title":"French Mycoses Study Group. Features of cryptococcosis among 652 HIV-seronegative individuals in France: A cross-sectional observational study (2005\u20132020)","volume":"30","author":"Paccoud","year":"2024","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1097\/INF.0000000000004216","article-title":"Pediatric Cryptococcosis","volume":"43","author":"Gifford","year":"2024","journal-title":"Pediatr. Infect. Dis. J."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.4269\/ajtmh.24-0373","article-title":"Etiology and outcomes of meningitis among adults in three Ugandan referral hospitals, 2018\u20132023: A prospective cohort study in a high-HIV endemic setting","volume":"112","author":"Mugabi","year":"2025","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Wang, F., Wang, Y., He, J., Cheng, Z., Wu, S., Wang, M., and Niu, T. (2022). Clinical characteristics and risk factors for mortality in cryptococcal meningitis: Evidence from a cohort study. Front. Neurol., 13.","DOI":"10.3389\/fneur.2022.779435"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s10875-024-01757-y","article-title":"Autoantibodies neutralizing GM-CSF in HIV-negative Colombian patients infected with Cryptococcus gattii and C. neoformans","volume":"44","author":"Rojas","year":"2024","journal-title":"J. Clin. Immunol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.cmi.2024.01.018","article-title":"Anti-GM-CSF autoantibodies predict outcome of cryptococcal meningitis in patients not infected with HIV: A cohort study","volume":"30","author":"Jiang","year":"2024","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_46","first-page":"20499361241232851","article-title":"COVID-19 associated with cryptococcosis: A scoping review","volume":"11","author":"Poma","year":"2024","journal-title":"Ther. Adv. Infect. Dis."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"102941","DOI":"10.1016\/j.jiph.2025.102941","article-title":"The outcomes of cryptococcal disease in HIV-positive individuals following COVID-19 infection: A systematic review and meta-analysis","volume":"18","author":"Malli","year":"2025","journal-title":"J. Infect. Public Health"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Howard-Jones, A.R., Sparks, R., Pham, D., Halliday, C., Beardsley, J., and Chen, S.C. (2022). Pulmonary cryptococcosis. J. Fungi, 8.","DOI":"10.3390\/jof8111156"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.jinf.2014.10.007","article-title":"Neurological, visual, and MRI brain scan findings in 87 South African patients with HIV-associated cryptococcal meningoencephalitis","volume":"70","author":"Loyse","year":"2015","journal-title":"J. Infect."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s13613-025-01516-1","article-title":"Neuroimaging for prognosis of central nervous system infections: A systematic review and meta-analysis","volume":"15","author":"Gaudemer","year":"2025","journal-title":"Ann. Intensive Care"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"e13767","DOI":"10.1111\/myc.13767","article-title":"Association between neuroimaging and clinical outcomes in individuals with central nervous system cryptococcosis","volume":"67","author":"Teixeira","year":"2024","journal-title":"Mycoses"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1086\/649858","article-title":"Clinical practice guidelines for the management of cryptococcal disease: 2010 update by the infectious diseases society of america","volume":"50","author":"Perfect","year":"2010","journal-title":"Clin. Infect. Dis."},{"key":"ref_53","unstructured":"World Health Organization (2018). Guidelines on the Diagnosis, Prevention and Management of Cryptococcal Disease in HIV-Infected Adults, Adolescents and Children: Supplement to the 2016 Consolidated Guidelines on the Use of Antiretroviral Drugs for Treating and Preventing HIV Infection, World Health Organization."},{"key":"ref_54","unstructured":"World Health Organization (2022). Guidelines for Diagnosing, Preventing and Managing Cryptococcal Disease Among Adults, Adolescents and Children Living with HIV, World Health Organization."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"e495","DOI":"10.1016\/S1473-3099(23)00731-4","article-title":"Global guideline for the diagnosis and management of cryptococcosis: An initiative of the ECMM and ISHAM in cooperation with the ASM","volume":"24","author":"Chang","year":"2024","journal-title":"Lancet Infect. Dis."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Mimicos, E.V., Fossaluza, V., Picone, C.M., de Sena, C.C., Gomes, H.R., L\u00e1zari, C.D., Ferreira da Silva, F., Shimoda Nakanishi, E., Vichr Nisida, E., and Carvalho Freitas, A. (2022). Prevalence and associated factors of cryptococcal antigenemia in HIV-infected patients with CD4 <200 cells\/\u00b5L in S\u00e3o Paulo, Brazil: A bayesian analysis. J. Fungi, 8.","DOI":"10.3390\/jof8121284"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Alves Soares, E., Lazera, M.D., Wanke, B., Faria Ferreira, M., Carvalhaes de Oliveira, R.V., Oliveira, A.G., and Coutinho, Z.F. (2019). Mortality by cryptococcosis in Brazil from 2000 to 2012: A descriptive epidemiological study. PLoS Negl. Trop. Dis., 13.","DOI":"10.1371\/journal.pntd.0007569"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"e0015622","DOI":"10.1128\/cmr.00156-22","article-title":"Diagnosis and management of cryptococcal meningitis in HIV-infected adults","volume":"36","author":"McHale","year":"2023","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/S1473-3099(22)00656-9","article-title":"Diagnostic capacity for invasive fungal infections in advanced HIV disease in Africa: A continent-wide survey","volume":"23","author":"Lakoh","year":"2023","journal-title":"Lancet Infect. Dis."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3201\/eid2001.130906","article-title":"Multisite validation of cryptococcal antigen lateral flow assay and quantification by laser thermal contrast","volume":"20","author":"Boulware","year":"2014","journal-title":"Emerg. Infect. Dis."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"e170554","DOI":"10.1590\/0074-02760170554","article-title":"Latin American Cryptococcal Study Group. The status of cryptococcosis in Latin America","volume":"113","author":"Firacative","year":"2018","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Melhem, M.S., Leite J\u00fanior, D.P., Takahashi, J.P., Macioni, M.B., Oliveira, L., de Ara\u00fajo, L.S., Fava, W.S., Bonfietti, L.X., Paniago, A.M., and Venturini, J. (2024). Antifungal resistance in cryptococcal infections. Pathogens, 13.","DOI":"10.3390\/pathogens13020128"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"100497","DOI":"10.1016\/j.clinpr.2025.100497","article-title":"Determinants of mortality in HIV-associated cryptococcal meningitis in Vietnam: Implications for optimizing management for resource-limited settings","volume":"27","author":"Doan","year":"2025","journal-title":"Clin. Infect. Pract."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"3599","DOI":"10.1093\/jac\/dkw325","article-title":"Global access to antifungal therapy and its variable cost","volume":"71","author":"Kneale","year":"2016","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.diagmicrobio.2012.02.018","article-title":"Cryptococcus gattii PNW Public Health Working Group. Epidemiologic cutoff values for triazole drugs in Cryptococcus gattii: Correlation of molecular type and in vitro susceptibility","volume":"73","author":"Lockhart","year":"2012","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"635","DOI":"10.3109\/13693786.2012.761737","article-title":"Susceptibility profile of clinical and environmental isolates of Cryptococcus neoformans and Cryptococcus gattii in Uberaba, Minas Gerais, Brazil","volume":"51","author":"Mora","year":"2013","journal-title":"Med. Mycol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s11046-012-9528-9","article-title":"Comparative analysis of the Vitek 2 antifungal susceptibility system and E-test with the CLSI M27-A3 broth microdilution method for susceptibility testing of indian clinical isolates of Cryptococcus neoformans","volume":"173","author":"Tewari","year":"2012","journal-title":"Mycopathologia"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1093\/cid\/cir723","article-title":"Cryptococcus gattii in the United States: Clinical aspects of infection with an emerging pathogen","volume":"53","author":"Harris","year":"2011","journal-title":"Clin. Infect. Dis."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"myae043","DOI":"10.1093\/mmy\/myae043","article-title":"Cryptococcosis-a systematic review to inform the World Health Organization Fungal Priority Pathogens List","volume":"62","author":"Dao","year":"2024","journal-title":"Med. Mycol."},{"key":"ref_70","unstructured":"Instituto Nacional de Salud (2025, October 09). Resoluci\u00f3n 1646 del 4 de Diciembre de 2018, Available online: https:\/\/www.ins.gov.co\/Normatividad\/Resoluciones\/RESOLUCION%201646%20DE%202018.pdf."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"94","DOI":"10.7705\/biomedica.v27i1.236","article-title":"Grupo Colombiano para el Estudio de la Criptococosis. Estudio cl\u00ednico y epidemiol\u00f3gico de la criptococosis en Colombia: Resultado de nueve a\u00f1os de la encuesta nacional, 1997\u20132005","volume":"27","author":"Lizarazo","year":"2007","journal-title":"Biom\u00e9dica"},{"key":"ref_72","first-page":"386","article-title":"Grupo Colombiano para el Estudio de la Criptococosis. Cryptococcosis in Colombia: Results of the national surveillance program for the years 2006\u20132010","volume":"32","author":"Lizarazo","year":"2012","journal-title":"Biom\u00e9dica"}],"container-title":["Journal of Fungi"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2309-608X\/12\/1\/67\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T11:36:49Z","timestamp":1768390609000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2309-608X\/12\/1\/67"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,14]]},"references-count":72,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1]]}},"alternative-id":["jof12010067"],"URL":"https:\/\/doi.org\/10.3390\/jof12010067","relation":{},"ISSN":["2309-608X"],"issn-type":[{"value":"2309-608X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,14]]}}}