{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T23:23:30Z","timestamp":1791933810725,"version":"4.3.4"},"reference-count":251,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T00:00:00Z","timestamp":1774051200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>Aspergillosis is one of the most common fungal infections worldwide, caused by various species belonging to the genus Aspergillus, affecting both immunocompetent and immunocompromised individuals. The objective of this review was to provide an update on the last five years regarding various aspects of this mycosis, including epidemiology, risk factors, diagnosis, susceptibility, and treatment. The results showed that aspergillosis is distributed throughout the world. Furthermore, A. terreus was found to be an increasing causative agent in cases of aspergillosis, along with other less common species. Regarding clinical forms, particularly in the case of Allergic Bronchopulmonary Aspergillosis (ABPA), it is necessary to consider patients with structural lung impairment (Chronic Obstructive Pulmonary Disease (COPD) and Interstitial Lung Diseases). Meanwhile, newly identified risk factors for the development of aspergillosis include chronic obstructive pulmonary disease (odds ratio 1.88) and interstitial lung disease (OR 3.71). Furthermore, the main diagnostic methodologies for aspergillosis were polymerase chain reaction (PCR), matrix-assisted laser desorption\/ionization time-of-flight (MALDI-TOF), and next-generation sequencing (NGS). Additionally, the usefulness of isavuconazole compared to voriconazole was demonstrated, representing a better alternative for the treatment of aspergillosis, while novel antifungals such as olorofim and fosmanogepix show excellent results in the management of aspergillosis. Due to the discovery of new risk factors, coupled with antifungal resistance in Aspergillus spp. and the wide variety of diagnostic tools, individualized assessment of aspergillosis cases is necessary for the appropriate management of this mycosis.<\/jats:p>","DOI":"10.3390\/jof12030229","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T09:48:42Z","timestamp":1774259322000},"page":"229","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Aspergillosis: An Update on Epidemiology, Risk Factors, Diagnosis, Susceptibility, and Treatment"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1277-7170","authenticated-orcid":false,"given":"Carlos Alberto","family":"Castro-Fuentes","sequence":"first","affiliation":[{"name":"Posgrado en Ciencias Biol\u00f3gicas, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de Mexico (UNAM), Ciudad Universitaria, Avenida Universidad 3000, Coyoac\u00e1n, Mexico City 04510, Mexico"},{"name":"Departamento de Microbiolog\u00eda y Parasitolog\u00eda, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de Mexico (UNAM), Ciudad Universitaria, Avenida Universidad 3000, Coyoac\u00e1n, Mexico City 04510, Mexico"},{"name":"Unidad de Investigaci\u00f3n, Hospital Regional de Alta Especialidad de Ixtapaluca (HRAEI), Servicios de Salud del Instituto Mexicano de Seguro Social para el Bienestar (IMSS-BIENESTAR), Carretera Federal Mexico-Puebla Km 34.5, Ixtapaluca 56530, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Pablo","family":"Cabrera-Guerrero","sequence":"additional","affiliation":[{"name":"Servicio de Microbiolog\u00eda, Instituto Nacional de Enfermedades Respiratorias \u201cIsmael Cos\u00edo Villegas\u201d (INER), Calz. de Tlalpan 4502, Belisario Dom\u00ednguez Secc 16, Tlalpan, Mexico City 14080, Mexico"},{"name":"Servicio de Infectolog\u00eda, Hospital Regional de Alta Especialidad de Ixtapaluca (HRAEI), Servicios de Salud del Instituto Mexicano de Seguro Social para el Bienestar (IMSS-BIENESTAR), Carretera Federal M\u00e9xico-Puebla Km 34.5, Ixtapaluca 56530, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6315-7860","authenticated-orcid":false,"given":"Esperanza","family":"Duarte-Escalante","sequence":"additional","affiliation":[{"name":"Departamento de Microbiolog\u00eda y Parasitolog\u00eda, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de Mexico (UNAM), Ciudad Universitaria, Avenida Universidad 3000, Coyoac\u00e1n, Mexico City 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graciela","family":"Hern\u00e1ndez Silva","sequence":"additional","affiliation":[{"name":"Servicio de Infectolog\u00eda, Instituto Nacional de Enfermedades Respiratorias \u201cIsmael Cos\u00edo Villegas\u201d (INER), Calz. de Tlalpan 4502, Belisario Dom\u00ednguez Secc 16, Tlalpan, Mexico City 14080, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4109-7817","authenticated-orcid":false,"given":"Alberto","family":"Chinney Herrera","sequence":"additional","affiliation":[{"name":"Centro Nacional de Prevenci\u00f3n y Control de Enfermedades (CENAPRECE), Francisco de P. Miranda No. 157, Col. Unidad Lomas de Plateros, \u00c1lvaro Obreg\u00f3n, Mexico City 01480, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3866-9995","authenticated-orcid":false,"given":"Mar\u00eda del Roc\u00edo","family":"Reyes-Montes","sequence":"additional","affiliation":[{"name":"Departamento de Microbiolog\u00eda y Parasitolog\u00eda, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de Mexico (UNAM), Ciudad Universitaria, Avenida Universidad 3000, Coyoac\u00e1n, Mexico City 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.mimet.2015.08.007","article-title":"PCR-RFLP on \u03b2-tubulin gene for rapid identification of the most clinically important species of Aspergillus","volume":"117","author":"Nasri","year":"2015","journal-title":"J. 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