{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:43:30Z","timestamp":1790959410812,"version":"4.1.0"},"reference-count":34,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>Candidozyma auris (formerly Candida auris) is frequently multidrug-resistant, resulting in limited treatment options and high mortality. Comparable mortality between C. auris candidemia and non-C. auris candidemia in recent studies requires confirmation in the Middle East after adjustment for confounders. This study aimed to compare mortality rates between patients with candidemia by C. auris and non-C. auris Candida species. We retrospectively analyzed 94 cases with candidemia between January 2019 and October 2025, including C. auris candidemia (n = 30) and non-C. auris candidemia (n = 64). Inverse probability weighting was used to balance baseline confounders between groups. The primary analysis used a weighted Cox proportional hazards model. Patients in the C. auris group had more comorbidities, greater healthcare exposure, and longer hospital stays. Crude 30-day all-cause cumulative mortality was comparable between the C. auris and non-C. auris groups (log-rank test, p = 0.8). The 30-day mortality of C. auris candidemia was similar to that of non-C. auris candidemia (adjusted HR 0.40; 95% CI 0.16\u20131.04; p = 0.060). Large multicenter studies involving diverse populations across different regions are warranted to validate these findings.<\/jats:p>","DOI":"10.3390\/jof12040234","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T10:07:13Z","timestamp":1774433233000},"page":"234","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Mortality of Candidozyma auris Candidemia Compared with Non-C. auris Candidemia"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8441-3333","authenticated-orcid":false,"given":"Sungsoo","family":"Park","sequence":"first","affiliation":[{"name":"Division of Medicine, Sheikh Khalifa Specialty Hospital, Ras Al Khaimah P.O. Box 6365, United Arab Emirates"},{"name":"Department of Pulmonology, Seoul National University Hospital, Seoul 03080, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heesuk","family":"Kim","sequence":"additional","affiliation":[{"name":"Environmental Safety Healthcare Provider Team, Sheikh Khalifa Specialty Hospital, Ras Al Khaimah P.O. Box 6365, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kilchae","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Sheikh Khalifa Specialty Hospital, Ras Al Khaimah P.O. Box 6365, United Arab Emirates"},{"name":"Department of Laboratory Medicine, Seoul National University Hospital, Seoul 03080, Republic of Korea"},{"name":"PureLab, Sheikh Khalifa Specialty Hospital, Ras Al Khaimah P.O. Box 6365, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duckjin","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Sheikh Khalifa Specialty Hospital, Ras Al Khaimah P.O. Box 6365, United Arab Emirates"},{"name":"PureLab, Sheikh Khalifa Specialty Hospital, Ras Al Khaimah P.O. Box 6365, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3571-1905","authenticated-orcid":false,"given":"Hyeyoung","family":"Oh","sequence":"additional","affiliation":[{"name":"Division of Medicine, Sheikh Khalifa Specialty Hospital, Ras Al Khaimah P.O. Box 6365, United Arab Emirates"},{"name":"Environmental Safety Healthcare Provider Team, Sheikh Khalifa Specialty Hospital, Ras Al Khaimah P.O. Box 6365, United Arab Emirates"},{"name":"Department of Family Medicine, Seoul National University Hospital, Seoul 03080, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,25]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2025, April 02). WHO Fungal Priority Pathogens List to Guide Research, Development and Public Health Action. Available online: https:\/\/www.who.int\/publications\/i\/item\/9789240060241."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Chaabane, F., Graf, A., Jequier, L., and Coste, A.T. (2019). Review on Antifungal Resistance Mechanisms in the Emerging Pathogen Candida auris. Front. Microbiol., 10.","DOI":"10.3389\/fmicb.2019.02788"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e02396-16","DOI":"10.1128\/AAC.02396-16","article-title":"The Emerging Pathogen Candida auris: Growth Phenotype, Virulence Factors, Activity of Antifungals, and Effect of SCY-078, a Novel Glucan Synthesis Inhibitor, on Growth Morphology and Biofilm Formation","volume":"61","author":"Larkin","year":"2017","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1111\/myc.12904","article-title":"Candida auris-the growing menace to global health","volume":"62","author":"Lone","year":"2019","journal-title":"Mycoses"},{"key":"ref_5","first-page":"e00029-17","article-title":"Candida auris: A Review of the Literature","volume":"31","author":"Taori","year":"2017","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_6","first-page":"3","article-title":"Global emergence of a multi-drug resistant fungal pathogen, Candida auris","volume":"31","author":"Britz","year":"2016","journal-title":"South. Afr. J. Infect. Dis."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"155","DOI":"10.2147\/IDR.S116229","article-title":"Current perspective on emergence, diagnosis and drug resistance in Candida auris","volume":"10","author":"Sarma","year":"2017","journal-title":"Infect. Drug Resist."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e1436","DOI":"10.1093\/cid\/ciac735","article-title":"Comparative Outcomes of Candida auris Bloodstream Infections: A Multicenter Retrospective Case-Control Study","volume":"76","author":"Simon","year":"2023","journal-title":"Clin. Infect. Dis."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Ortiz-Roa, C., Valderrama-Rios, M.C., Sierra-Uma\u00f1a, S.F., Rodr\u00edguez, J.Y., Mu\u00f1et\u00f3n-L\u00f3pez, G.A., Sol\u00f3rzano-Ramos, C.A., Escand\u00f3n, P., Alvarez-Moreno, C.A., and Cort\u00e9s, J.A. (2023). Mortality Caused by Candida auris Bloodstream Infections in Comparison with Other Candida Species, a Multicentre Retrospective Cohort. J. Fungi, 9.","DOI":"10.3390\/jof9070715"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Alvarez-Moreno, C.A., Morales-L\u00f3pez, S., Rodriguez, G.J., Rodriguez, J.Y., Robert, E., Picot, C., Ceballos-Garzon, A., Parra-Giraldo, C.M., and Le Pape, P. (2023). The Mortality Attributable to Candidemia in C. auris Is Higher than That in Other Candida Species: Myth or Reality?. J. Fungi, 9.","DOI":"10.3390\/jof9040430"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Thomsen, J., Abdulrazzaq, N.M., Oulhaj, A., Nyasulu, P.S., Alatoom, A., Denning, D.W., Al Dhaheri, F., UAEAMRSurveillance, C.o.n.s.o.r.t.i.u.m., Menezes, G.A., and Moubareck, C.A. (2024). Emergence of highly resistant Candida auris in the United Arab Emirates: A retrospective analysis of evolving national trends. Front. Public Health, 11.","DOI":"10.3389\/fpubh.2023.1244358"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1007\/s11046-020-00478-1","article-title":"Case-Case Comparison of Candida auris Versus Other Candida Species Bloodstream Infections: Results of an Outbreak Investigation in Colombia","volume":"185","author":"Caceres","year":"2020","journal-title":"Mycopathologia"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1093\/mmy\/myz112","article-title":"Comparison of risk factors and outcomes of Candida auris candidemia with non-Candida auris candidemia: A retrospective study from Pakistan","volume":"58","author":"Sayeed","year":"2020","journal-title":"Med. Mycol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e280","DOI":"10.1016\/S1473-3099(24)00749-7","article-title":"Global guideline for the diagnosis and management of candidiasis: An initiative of the ECMM in cooperation with ISHAM and ASM","volume":"25","author":"Cornely","year":"2025","journal-title":"Lancet Infect. Dis."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1086\/504810","article-title":"Time to initiation of fluconazole therapy impacts mortality in patients with candidemia: A multi-institutional study","volume":"43","author":"Garey","year":"2006","journal-title":"Clin. Infect. Dis."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"658329","DOI":"10.3389\/fmicb.2021.658329","article-title":"Retrospective Analysis of the Clinical Characteristics of Candida auris Infection Worldwide From 2009 to 2020","volume":"12","author":"Hu","year":"2021","journal-title":"Front. Microbiol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"G\u00fclten, E., \u00c7\u0131nar, G., Sar\u0131cao\u011flu, E.M., Akdemir, \u0130., Y\u0131lmaz, A.Z., Saldere, E.H., and Y\u00f6r\u00fck, F. (2025). Candida auris vs. Non-Candida auris Candidemia in Critically Ill Patients: Clinical Outcomes, Risk Factors, and Mortality. J. Fungi, 11.","DOI":"10.3390\/jof11080552"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1086\/599039","article-title":"Epidemiology and outcomes of candidemia in 2019 patients: Data from the prospective antifungal therapy alliance registry","volume":"48","author":"Horn","year":"2009","journal-title":"Clin. Infect. Dis."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Cao, Y., Li, Y., Wang, M., Wu, Y., Shi, S., Wang, C., Gao, Z., Yang, W., Wang, L., and Kang, H. (2025). Epidemiological shifts and advances in research on early diagnosis of invasive fungal infection in critically ill patients. Front. Cell Infect. Microbiol., 15.","DOI":"10.3389\/fcimb.2025.1658476"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"3081","DOI":"10.3389\/fmicb.2018.03081","article-title":"Candida auris: What Have We Learned About Its Mechanisms of Pathogenicity?","volume":"9","author":"Rossato","year":"2018","journal-title":"Front. Microbiol."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Pyrpasopoulou, A., Zarras, C., Mouloudi, E., Vakalis, G., Ftergioti, A., Kouroupis, D., Papathanasiou, A.I., Iosifidis, E., Goumperi, S., and Lampada, C. (2025). Changing Epidemiology of Candida spp. Causing Bloodstream Infections in a Tertiary Hospital in Northern Greece: Appearance of Candida auris. Pathogens, 14.","DOI":"10.3390\/pathogens14020161"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s40588-020-00143-7","article-title":"Candida auris infection and biofilm formation: Going beyond the surface","volume":"7","author":"Horton","year":"2020","journal-title":"Curr. Clin. Microbiol. Rep."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"783","DOI":"10.2147\/IDR.S197531","article-title":"Differential recognition of Candida tropicalis, Candida guilliermondii, Candida krusei, and Candida auris by human innate immune cells","volume":"12","author":"Franco","year":"2019","journal-title":"Infect. Drug Resist."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"e01403-18","DOI":"10.1128\/mBio.01403-18","article-title":"Emerging Fungal Pathogen Candida auris Evades Neutrophil Attack","volume":"9","author":"Johnson","year":"2018","journal-title":"mBio"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Du, H., Bing, J., Hu, T., Ennis, C.L., Nobile, C.J., and Huang, G. (2020). Candida auris: Epidemiology, biology, antifungal resistance, and virulence. PLoS Pathog., 16.","DOI":"10.1371\/journal.ppat.1008921"},{"key":"ref_26","unstructured":"Jenks, J., Tobin, E.H., and Zahra, F. (2026, February 15). Candida auris, StatPearls, Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK563297\/."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.bjid.2018.10.278","article-title":"Time of catheter removal in candidemia and mortality","volume":"22","author":"Nucci","year":"2018","journal-title":"Braz. J. Infect. Dis."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.jhin.2019.08.018","article-title":"Clinical impacts of delayed central venous catheter removal according to the severity of comorbidities in patients with candidaemia","volume":"103","author":"Lee","year":"2019","journal-title":"J. Hosp. Infect."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"3640","DOI":"10.1128\/AAC.49.9.3640-3645.2005","article-title":"Delaying the empiric treatment of candida bloodstream infection until positive blood culture results are obtained: A potential risk factor for hospital mortality","volume":"49","author":"Morrell","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.jinf.2020.01.002","article-title":"Efficacy and safety of a comprehensive educational antimicrobial stewardship program focused on antifungal use","volume":"80","author":"Aguilar","year":"2020","journal-title":"J. Infect."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1093\/jac\/dkz491","article-title":"An evidence-based bundle improves the quality of care and outcomes of patients with candidaemia","volume":"75","author":"Cardozo","year":"2020","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1086\/653935","article-title":"Early removal of central venous catheter in patients with candidemia does not improve outcome: Analysis of 842 patients from 2 randomized clinical trials","volume":"51","author":"Nucci","year":"2010","journal-title":"Clin. Infect. Dis."},{"key":"ref_33","first-page":"e69988","article-title":"Prevalence and Outcomes of Candida auris Infections in a Tertiary Hospital in the United Arab Emirates (UAE)","volume":"16","author":"Subhi","year":"2024","journal-title":"Cureus"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"106586","DOI":"10.1016\/j.jinf.2025.106586","article-title":"Persistent candidemia caused by different Candida species: Data from a multicenter contemporary cohort","volume":"91","author":"Tiseo","year":"2025","journal-title":"J. Infect."}],"container-title":["Journal of Fungi"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2309-608X\/12\/4\/234\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T10:59:10Z","timestamp":1774436350000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2309-608X\/12\/4\/234"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,25]]},"references-count":34,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,4]]}},"alternative-id":["jof12040234"],"URL":"https:\/\/doi.org\/10.3390\/jof12040234","relation":{},"ISSN":["2309-608X"],"issn-type":[{"value":"2309-608X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,25]]}}}