{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:27:12Z","timestamp":1777692432481,"version":"3.51.4"},"reference-count":47,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>Candida albicans is a yeast found in the oral cavity, gastrointestinal tract, and vaginal mucosa. This species is the most prevalent and virulent in conditions such as oral candidiasis. Myrtenol is a bicyclic monoterpene alcohol recognized for its antioxidant and anti-inflammatory attributes. Its primary source is the essential oil extracted from plants of the Myrtaceae family. This study evaluated the effect of (\u2212)-myrtenol on the virulence factors of Candida albicans. Ten clinical isolates of Candida albicans and one reference strain (ATCC 90028) were used in this study. The virulence factors examined included adhesion, morphogenesis, and lipase production. Assays were conducted in the presence and absence of (\u2212)-myrtenol, using a concentration corresponding to the minimum inhibitory concentration (MIC; 256 \u00b5g\/mL). Results: The compound reduced the adherence of C. albicans to human oral epithelial cells (92.24 vs. 28.69), and reduced filamentation in liquid (3.17 vs. 2.57) and solid media. Furthermore, (\u2212)-myrtenol inhibited lipase activity (0.68 vs. 1.00). Virulence factors expressed by C. albicans contribute to increased infection rates and, consequently, increased morbidity and mortality. The present findings demonstrate that (\u2212)-myrtenol affects virulence-associated phenotypes of C. albicans in vitro. This compound represents a promising candidate for further investigation, particularly in studies addressing its mechanisms of action, safety, and potential applicability.<\/jats:p>","DOI":"10.3390\/jof12050325","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:43:51Z","timestamp":1777448631000},"page":"325","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["In Vitro Activity of (\u2212)-Myrtenol on Adherence, Morphogenesis and Lipase Activity in Candida albicans Isolated from the Oral Cavity"],"prefix":"10.3390","volume":"12","author":[{"given":"Camila Mendes","family":"Soares","sequence":"first","affiliation":[{"name":"Clinical Mycology Laboratory, Department of Pharmaceutical Sciences, Federal University of Para\u00edba, Jo\u00e3o Pessoa 58051-900, Para\u00edba, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5073-7033","authenticated-orcid":false,"given":"Larissa","family":"Alves da Silva","sequence":"additional","affiliation":[{"name":"Clinical Mycology Laboratory, Department of Pharmaceutical Sciences, Federal University of Para\u00edba, Jo\u00e3o Pessoa 58051-900, Para\u00edba, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luanna de Oliveira e","family":"Lima","sequence":"additional","affiliation":[{"name":"Clinical Mycology Laboratory, Department of Pharmaceutical Sciences, Federal University of Para\u00edba, Jo\u00e3o Pessoa 58051-900, Para\u00edba, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1734-1177","authenticated-orcid":false,"given":"Meryellem Bezerra","family":"Soares","sequence":"additional","affiliation":[{"name":"Clinical Mycology Laboratory, Department of Pharmaceutical Sciences, Federal University of Para\u00edba, Jo\u00e3o Pessoa 58051-900, Para\u00edba, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raimundo Euzebio da Costa","family":"Neto","sequence":"additional","affiliation":[{"name":"Clinical Mycology Laboratory, Department of Pharmaceutical Sciences, Federal University of Para\u00edba, Jo\u00e3o Pessoa 58051-900, Para\u00edba, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9567-4096","authenticated-orcid":false,"given":"Jos\u00e9 Maria","family":"Barbosa Filho","sequence":"additional","affiliation":[{"name":"Pharmaceutical Technology Laboratory, Department of Pharmaceutical Sciences, Federal University of Para\u00edba, Jo\u00e3o Pessoa 58051-900, Para\u00edba, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2057-4821","authenticated-orcid":false,"given":"Felipe Queiroga Sarmento","family":"Guerra","sequence":"additional","affiliation":[{"name":"Clinical Mycology Laboratory, Department of Pharmaceutical Sciences, Federal University of Para\u00edba, Jo\u00e3o Pessoa 58051-900, Para\u00edba, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guilherme Maranh\u00e3o","family":"Chaves","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Mycology, DMIC\u2014Department of Mycology\u2014BC, Federal University of Pernambuco, Recife 50670-901, Pernambuco, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walicyranison Pl\u00ednio da","family":"Silva-Rocha","sequence":"additional","affiliation":[{"name":"Clinical Mycology Laboratory, Department of Pharmaceutical Sciences, Federal University of Para\u00edba, Jo\u00e3o Pessoa 58051-900, Para\u00edba, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"91","DOI":"10.17695\/issn.2317-7160.v16n2a2018p91-99","article-title":"Microrganismos habitantes da cavidade oral e sua rela\u00e7\u00e3o com patologias orais e sist\u00eamicas: Revis\u00e3o de literatura","volume":"16","author":"Germano","year":"2018","journal-title":"Rev. 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