{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T15:42:00Z","timestamp":1785426120270,"version":"3.56.0"},"reference-count":78,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Medicine and Pharmacy Carol Davila"},{"id":[{"id":"https:\/\/ror.org\/04fm87419","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>Invasive candidiasis is a significant concern in healthcare environments, and awareness of these infections has increased in recent years. A growing number of risk factors, the ability of some Candida species to progress from colonization to tissue invasion, and their capacity to adhere to and survive on abiotic surfaces have all contributed to the spread of invasive candidiasis. The primary goal in cases of invasive candidiasis is to diagnose it as promptly as possible, as any delay can delay antifungal treatment. This review concentrates on clinical syndromes reunited under the definition of invasive candidiasis and the current diagnostic methods. Risk factor assessment is another major topic of this narrative review and recent updates are included. Research stage biomarkers are also explored and partial results are mentioned as there are continuous efforts to search for new tools for a more accurate prediction or an earlier identification of IC.<\/jats:p>","DOI":"10.3390\/jof12060383","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T11:57:44Z","timestamp":1779710264000},"page":"383","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Overview of Risk Factors and Diagnosis of Invasive Candidiasis"],"prefix":"10.3390","volume":"12","author":[{"given":"Valentina Daniela","family":"Sisu","sequence":"first","affiliation":[{"name":"Faculty of Medicine, University of Medicine and Pharmacy, Carol Davila, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anda","family":"B\u0103icu\u0219","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Medicine and Pharmacy, Carol Davila, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"106229","DOI":"10.1016\/j.jinf.2024.106229","article-title":"Attributable mortality of candidemia\u2014Results from the ECMM Candida III multinational European Observational Cohort Study","volume":"89","author":"Cornely","year":"2024","journal-title":"J. Infect."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/s13054-016-1313-6","article-title":"Diagnosis and management of invasive candidiasis in the ICU: An updated approach to an old enemy","volume":"20","author":"Calandra","year":"2016","journal-title":"Crit. Care"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1016\/j.cmi.2019.04.024","article-title":"Morbidity and mortality of candidaemia in Europe: An epidemiologic meta-analysis","volume":"25","author":"Koehler","year":"2019","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_4","first-page":"e428\u201338","article-title":"Global incidence and mortality of severe fungal disease","volume":"24","author":"Denning","year":"2024","journal-title":"Lancet Infect. Dis."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1186\/s13054-019-2497-3","article-title":"Incidence and outcome of invasive candidiasis in intensive care units (ICUs) in Europe: Results of the EUCANDICU project","volume":"23","author":"Bassetti","year":"2019","journal-title":"Crit. Care"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1016\/j.ajt.2025.07.2480","article-title":"Invasive Candida infections in solid organ transplant recipients between 2008 and 2020","volume":"25","author":"Meyer","year":"2025","journal-title":"Am. J. Transplant."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"102804","DOI":"10.1016\/j.jiph.2025.102804","article-title":"Epidemiology of invasive fungal diseases in patients with hematological malignancies and haematopoietic cell transplantation recipients: Systematic review and meta-analysis of trends over time","volume":"18","author":"Popova","year":"2025","journal-title":"J. Infect. Public Health"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Pais, M.M., Zaragoza, R., Mart\u00edn-Loeches, I., G\u00f3mez-Bertomeu, F.F., and Rodr\u00edguez, A. (2025). Management of Intra-Abdominal Candidiasis in Intensive Care Setting: A Narrative Review. J. Fungi, 11.","DOI":"10.20944\/preprints202503.0464.v1"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Miram\u00f3n, P., Dunker, C., Windecker, H., Bohovych, I.M., Brown, A.J.P., Kurzai, O., and Hube, B. (2012). Cellular responses of Candida albicans to Phagocytosis and the extracellular activities of Neutrophils are critical to counteract carbohydrate starvation, oxidative and nitrosative stress. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0052850"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.chest.2021.08.081","article-title":"Risk Factors for Invasive Candida Infection in Critically Ill Patients: A Systematic Review and Meta-analysis","volume":"161","author":"Schlattmann","year":"2022","journal-title":"Chest"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/s13054-020-2766-1","article-title":"Risk factors for candidemia: A prospective matched case-control study","volume":"24","author":"Poissy","year":"2020","journal-title":"Crit. Care"},{"key":"ref_12","first-page":"139","article-title":"Risk factors for candidemia in non-neutropenic critical patients in Colombia","volume":"40","author":"Osorio","year":"2016","journal-title":"Med. Intensiva"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1177\/0884533610368704","article-title":"Candidemia Incidence in Recipients of Parenteral Nutrition","volume":"25","author":"Stratman","year":"2010","journal-title":"Nutr. Clin. Pract."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e036452","DOI":"10.1136\/bmjopen-2019-036452","article-title":"Risk of invasive candidiasis with prolonged duration of ICU stay: A systematic review and meta-analysis","volume":"10","author":"Zhang","year":"2020","journal-title":"BMJ Open"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/2110-5820-1-37","article-title":"Diagnosis of invasive candidiasis in the ICU","volume":"1","author":"Eggimann","year":"2011","journal-title":"Ann. Intensive Care"},{"key":"ref_16","first-page":"14","article-title":"Candida spp. Colonization among Intensive Care Unit Patients, Preliminary Results","volume":"5","author":"Nascimento","year":"2021","journal-title":"Med. Sci. Forum"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"7038","DOI":"10.3390\/ijms12107038","article-title":"Candida Colonization Index in Patients Admitted to an ICU","volume":"12","author":"Caggiano","year":"2011","journal-title":"Int. J. Mol. Sci."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Nascimento, T., In\u00e1cio, J., Guerreiro, D., Patr\u00edcio, P., Proen\u00e7a, L., Toscano, C., Diaz, P., and Barroso, H. (2024). Insights into Candida Colonization in Intensive Care Unit Patients: A Prospective Multicenter Study. J. Fungi, 10.","DOI":"10.3390\/jof10060378"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1097\/01.CCM.0000202208.37364.7D","article-title":"EPCAN Study Group. A bedside scoring system (\u201cCandida score\u201d) for early antifungal treatment in nonneutropenic critically ill patients with Candida colonization","volume":"34","author":"Saavedra","year":"2006","journal-title":"Crit. Care Med."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Glava\u0161 Tahtler, J., Cicvari\u0107, A., Koulenti, D., Karvouniaris, M., Bogdan, M., Kralik, K., Krajina Kmoni\u010dek, I., Grbi\u0107 Mlinarevi\u0107, M., and Kvolik, S. (2024). Isolation of Candida Species Is Associated with Comorbidities, Prolonged Mechanical Ventilation, and Treatment Outcomes in Surgical ICU Patients, a Cross-Sectional Study. J. Fungi, 10.","DOI":"10.3390\/jof10110743"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1128\/AAC.05947-11","article-title":"Antibiotic Exposure as a Risk Factor for Fluconazole-Resistant Candida Bloodstream Infection","volume":"56","author":"Krieger","year":"2012","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/myc.13403","article-title":"Invasive fungal infections in acute and chronic liver impairment: A systematic review","volume":"65","author":"Lahmer","year":"2022","journal-title":"Mycoses"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.micpath.2018.07.018","article-title":"Fungal biofilms in the hemodialysis environment","volume":"123","author":"Oliveira","year":"2018","journal-title":"Microb. Pathog."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Azim, A., and Ahmed, A. (2024). Diagnosis and management of invasive fungal diseases in non-neutropenic ICU patients, with focus on candidiasis and aspergillosis: A comprehensive review. Front. Cell. Infect. Microbiol., 14.","DOI":"10.3389\/fcimb.2024.1256158"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Moser, D., Biere, K., Han, B., Hoerl, M., Schelling, G., Chouk\u00e9r, A., and Woehrle, T. (2021). COVID-19 Impairs Immune Response to Candida albicans. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.640644"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.jointm.2023.07.005","article-title":"Severe Candida infections in critically ill patients with COVID-19","volume":"3","author":"Koulenti","year":"2023","journal-title":"J. Intensive Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"O50","DOI":"10.1111\/1469-0691.12312","article-title":"A prospective, cohort, multicentre study of candidaemia in hospitalized adult patients with haematological malignancies","volume":"20","author":"Gamaletsou","year":"2014","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_28","first-page":"6058567","article-title":"Invasive Candida Infection after Upper Gastrointestinal Tract Surgery for Gastric Cancer","volume":"2017","author":"Brotfain","year":"2017","journal-title":"Int. J. Surg. Oncol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"i4","DOI":"10.1093\/jac\/dkx444","article-title":"Changes in the epidemiological landscape of invasive candidiasis","volume":"73","author":"Lamoth","year":"2018","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1093\/infdis\/jir867","article-title":"Toll-like Receptor 1 Polymorphisms Increase Susceptibility to Candidemia","volume":"205","author":"Plantinga","year":"2012","journal-title":"J. Infect. Dis."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/ni1425","article-title":"Dectin-1 is required for host defense against Pneumocystis carinii but not against Candida albicans","volume":"8","author":"Saijo","year":"2007","journal-title":"Nat. Immunol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1056\/NEJMoa0810719","article-title":"A homozygous CARD9 mutation in a family with susceptibility to fungal infections","volume":"361","author":"Glocker","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Dermitzaki, N., Baltogianni, M., Tsekoura, E., and Giapros, V. (2024). Invasive Candida Infections in Neonatal Intensive Care Units: Risk Factors and New Insights in Prevention. Pathogens, 13.","DOI":"10.20944\/preprints202407.0540.v1"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s12281-023-00455-3","article-title":"Candidiasis and Other Emerging Yeasts","volume":"17","author":"Sharma","year":"2023","journal-title":"Curr. Fungal Infect. Rep."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"de Almeida, B.L., Agnelli, C., Guimar\u00e3es, T., Sukiennik, T., Lima, P.R.P., Salles, M.J.C., Breda, G.L., Queiroz-Telles, F., Mendes, A.V.A., and Camargo, L.F.A. (2025). Candidemia in ICU Patients: What Are the Real Game-Changers for Survival?. J. Fungi, 11.","DOI":"10.3390\/jof11020152"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1007\/s40121-021-00585-6","article-title":"Risk Factors for Intra-Abdominal Candidiasis in Intensive Care Units: Results from EUCANDICU Study","volume":"11","author":"Bassetti","year":"2022","journal-title":"Infect. Dis. Ther."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/s13054-017-1686-1","article-title":"Contribution of Candida biomarkers and DNA detection for the diagnosis of invasive candidiasis in ICU patients with severe abdominal conditions","volume":"21","author":"Saavedra","year":"2017","journal-title":"Crit. Care"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Vergidis, P., Clancy, C.J., Shields, R.K., Park, S.Y., Wildfeuer, B.N., Simmons, R.L., and Nguyen, M.H. (2016). Intra-Abdominal Candidiasis: The Importance of Early Source Control and Antifungal Treatment. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0153247"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Vazquez, J.A., Whitaker, L., and Zubovskaia, A. (2025). Invasive Candidiasis in the Intensive Care Unit: Where Are We Now?. J. Fungi, 11.","DOI":"10.3390\/jof11040258"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Talapko, J., Juzba\u0161i\u0107, M., Matijevi\u0107, T., Pustijanac, E., Beki\u0107, S., Kotris, I., and \u0160krlec, I. (2021). Candida albicans-The Virulence Factors and Clinical Manifestations of Infection. J. Fungi, 7.","DOI":"10.3390\/jof7020079"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1159\/000520111","article-title":"Candida Pneumonia: An Innocent Bystander or a Silent Killer?","volume":"31","author":"Meena","year":"2022","journal-title":"Med. Princ. Pract."},{"key":"ref_42","first-page":"209","article-title":"Epidemiology of candiduria and Candida urinary tract infections in inpatients and outpatients: Results from a 10-year retrospective survey","volume":"72","year":"2019","journal-title":"Cent. Eur. J. Urol."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Baltogianni, M., Giapros, V., and Dermitzaki, N. (2024). Recent Challenges in Diagnosis and Treatment of Invasive Candidiasis in Neonates. Children, 11.","DOI":"10.20944\/preprints202408.1064.v1"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"S121","DOI":"10.1093\/cid\/ciaa1751","article-title":"EORTC\/MSGERC Definitions of Invasive Fungal Diseases: Summary of Activities of the Intensive Care Unit Working Group","volume":"72","author":"Bassetti","year":"2021","journal-title":"Clin. Infect. Dis."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/imj.15589","article-title":"Australasian Antifungal Guidelines Steering Committee. Consensus guidelines for the diagnosis and management of invasive candidiasis in haematology, oncology and intensive care settings, 2021","volume":"51","author":"Keighley","year":"2021","journal-title":"Intern Med. J."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/s13613-020-00713-4","article-title":"Expert consensus-based clinical practice guidelines management of intravascular catheters in the intensive care unit","volume":"10","author":"Timsit","year":"2020","journal-title":"Ann. Intensive Care"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"105227","DOI":"10.1016\/j.idnow.2025.105227","article-title":"Prognosis of central venous catheter-related Candida infection during hospitalization in conventional medical or surgical wards: A 13-year retrospective cohort study","volume":"56","author":"Zaghdoudi","year":"2026","journal-title":"Infect. Dis. Now"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Alves, J., Alonso-Tarr\u00e9s, C., and Rello, J. (2022). How to Identify Invasive Candidemia in ICU\u2014A Narrative Review. Antibiotics, 11.","DOI":"10.3390\/antibiotics11121804"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.riam.2016.12.001","article-title":"on behalf of the J\u00e1vea Intra-Abdominal Fungal Infection Group. J\u00e1vea consensus guidelines for the treatment of Candida peritonitis and other intra-abdominal fungal infections in non-neutropenic critically ill adult patients","volume":"34","author":"Aguilar","year":"2017","journal-title":"Rev. Iberoam. Micol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"e280","DOI":"10.1016\/S1473-3099(24)00749-7","article-title":"Global guideline for the diagnosis and management of candidiasis: An initiative of the ECMM in cooperation with ISHAM and ASM","volume":"25","author":"Cornely","year":"2025","journal-title":"Lancet Infect. Dis."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"4094932","DOI":"10.1155\/2016\/4094932","article-title":"Comparative Evaluation of the BD Phoenix Yeast ID Panel and Remel RapID Yeast Plus System for Yeast Identification","volume":"2016","author":"Grant","year":"2016","journal-title":"Can. J. Infect. Dis. Med. Microbiol."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Barantsevich, N., and Barantsevich, E. (2022). Diagnosis and Treatment of Invasive Candidiasis. Antibiotics, 11.","DOI":"10.3390\/antibiotics11060718"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Brown, L., Cruciani, M., Morton, C.O., Alanio, A., Barnes, R.A., Donnelly, J.P., Hagen, F., Gorton, R., Lackner, M., and Loeffler, J. (2025). The Molecular Diagnosis of Invasive Fungal Diseases with a Focus on PCR. Diagnostics, 15.","DOI":"10.3390\/diagnostics15151909"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Finkelman, M.A. (2021). Specificity Influences in (1\u21923)-\u03b2-d-Glucan-Supported Diagnosis of Invasive Fungal Disease. J. Fungi, 7.","DOI":"10.3390\/jof7010014"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.ijid.2013.11.011","article-title":"Candidemia: Incidence rates, type of species, and risk factors at a tertiary care academic hospital in China","volume":"22","author":"Zengbin","year":"2014","journal-title":"Int. J. Infect. Dis."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"917","DOI":"10.21037\/atm-20-995","article-title":"Evaluation of the updated \u201cCandida score\u201d with Sepsis 3.0 criteria in critically ill patients","volume":"8","author":"Li","year":"2020","journal-title":"Ann. Transl. Med."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/2110-5820-1-50","article-title":"Evaluation of \u201cCandida score\u201d in critically ill patients: A prospective, multicenter, observational, cohort study","volume":"1","author":"Leroy","year":"2011","journal-title":"Ann. Intensive Care"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1111\/myc.13515","article-title":"Performance of existing clinical scores and laboratory tests for the diagnosis of invasive candidiasis in critically ill, nonneutropenic, adult patients: A systematic review with qualitative evidence synthesis","volume":"65","author":"Giacobbe","year":"2022","journal-title":"Mycoses"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1186\/cc10422","article-title":"Clinical prediction rules for invasive candidiasis in the ICU: Ready for prime time?","volume":"15","year":"2011","journal-title":"Crit. Care"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"El Zakhem, A., El Eid, R., Istambouli, R., Tamim, H., and Kanj, S.S. (2022). The Utility of EQUAL Candida Score in Predicting Mortality in Patients with Candidemia. J. Fungi, 8.","DOI":"10.3390\/jof8030238"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.mycmed.2019.08.002","article-title":"Candidemia in a Portuguese tertiary care hospital: Analysis of a 2-year period","volume":"29","author":"Martins","year":"2019","journal-title":"J. Mycol. Med."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"R198","DOI":"10.1186\/cc10366","article-title":"Validation and comparison of clinical prediction rules for invasive candidiasis in intensive care unit patients: A matched case-control study","volume":"15","author":"Hermsen","year":"2011","journal-title":"Crit. Care"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1097\/00000658-199412000-00008","article-title":"Candida colonization and subsequent infections in critically ill surgical patients","volume":"220","author":"Pittet","year":"1994","journal-title":"Ann. Surg."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Shahin, J., Allen, E.J., Patel, K., Muskett, H., Harvey, S.E., Edgeworth, J., Kibbler, C.C., Barnes, R.A., Biswas, S., and Soni, N. (2016). Predicting invasive fungal disease due to Candida species in non-neutropenic, critically ill, adult patients in United Kingdom critical care units. BMC Infect. Dis., 16.","DOI":"10.1186\/s12879-016-1803-9"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1007\/s15010-024-02465-w","article-title":"Predicting the risk of invasive fungal infections in ICU sepsis population: The AMI risk assessment tool","volume":"53","author":"Jin","year":"2025","journal-title":"Infection"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"R156","DOI":"10.1186\/cc8110","article-title":"Candidemia on presentation to the hospital: Development and validation of a risk score","volume":"13","author":"Shorr","year":"2009","journal-title":"Crit. Care"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.ejim.2017.03.005","article-title":"Assessment of risk factors for candidemia in non-neutropenic patients hospitalized in Internal Medicine wards: A multicenter study","volume":"41","author":"Falcone","year":"2017","journal-title":"Eur. J. Intern Med."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1007\/s15010-018-1162-0","article-title":"A prediction rule for early recognition of patients with candidemia in Internal Medicine: Results from an Italian, multicentric, case\u2013control study","volume":"46","author":"Sozio","year":"2018","journal-title":"Infection"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"e13275","DOI":"10.1111\/ijcp.13275","article-title":"Clinical predictors of candidemia in medical non-neutropenic, non-ICU patients. The CaMed score","volume":"72","author":"Hernandez","year":"2018","journal-title":"Int. J. Clin. Pract."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1093\/mmy\/myab043","article-title":"Clinical predictive models of invasive Candida infection: A systematic literature review","volume":"59","author":"Rauseo","year":"2021","journal-title":"Med. Mycol."},{"key":"ref_71","first-page":"e13297","article-title":"Als3-mediated attachment of enolase on the surface of Candida albicans cells regulates their interactions with host proteins","volume":"23","author":"Wronowska","year":"2021","journal-title":"Cell. Microbiol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1128\/EC.00194-06","article-title":"Function of Candida albicans adhesin Hwp1 in biofilm formation","volume":"5","author":"Nobile","year":"2006","journal-title":"Eukaryot. Cell"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"115509","DOI":"10.1016\/j.diagmicrobio.2021.115509","article-title":"Biomarkers for the diagnosis of invasive candidiasis in immunocompetent and immunocompromised patients","volume":"101","author":"Carrano","year":"2021","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"e0276923","DOI":"10.1128\/mbio.02769-23","article-title":"Identification of two anti-Candida antibodies associated with the survival of patients with candidemia","volume":"15","author":"Bromuro","year":"2024","journal-title":"mBio"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Satala, D., Karkowska-Kuleta, J., Zelazna, A., Rapala-Kozik, M., and Kozik, A. (2020). Moonlighting Proteins at the Candidal Cell Surface. Microorganisms, 8.","DOI":"10.3390\/microorganisms8071046"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"He, Z.-X., Shi, L.-C., Ran, X.-Y., Li, W., Wang, X.-L., and Wang, F.-K. (2016). Development of a Lateral Flow Immunoassay for the Rapid Diagnosis of Invasive Candidiasis. Front. Microbiol., 7.","DOI":"10.3389\/fmicb.2016.01451"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"4260","DOI":"10.1038\/s41467-018-06607-1","article-title":"The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes","volume":"9","author":"Kasper","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"e0324524","DOI":"10.1128\/spectrum.03245-24","article-title":"Detection of serum anti-candidalysin IgG by indirect ELISA: A novel auxiliary tool for diagnosing invasive candidiasis in a preliminary pediatric study","volume":"13","author":"Luo","year":"2025","journal-title":"Microbiol. Spectr."}],"container-title":["Journal of Fungi"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2309-608X\/12\/6\/383\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T12:33:26Z","timestamp":1779712406000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2309-608X\/12\/6\/383"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,25]]},"references-count":78,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["jof12060383"],"URL":"https:\/\/doi.org\/10.3390\/jof12060383","relation":{},"ISSN":["2309-608X"],"issn-type":[{"value":"2309-608X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,25]]}}}