{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T09:54:11Z","timestamp":1785405251267,"version":"3.56.0"},"reference-count":43,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011875","name":"Ministry of Science, Technology and Innovation","doi-asserted-by":"crossref","award":["761-2018\u2014Code N\u00b0 129980763078"],"award-info":[{"award-number":["761-2018\u2014Code N\u00b0 129980763078"]}],"id":[{"id":"10.13039\/501100011875","id-type":"DOI","asserted-by":"crossref"}]},{"award":["761-2018\u2014Code N\u00b0 129980763078"],"award-info":[{"award-number":["761-2018\u2014Code N\u00b0 129980763078"]}],"id":[{"id":"https:\/\/ror.org\/012s3r374","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Corporaci\u00f3n para Investigaciones Biol\u00f3gicas-CIB"},{"id":[{"id":"https:\/\/ror.org\/03evkbw14","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019424","name":"Universidad de Santander","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100019424","id-type":"DOI","asserted-by":"crossref"}]},{"id":[{"id":"https:\/\/ror.org\/03mx33742","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>Candida albicans remains one of the leading causes of invasive fungal infections and is recognized as a critical-priority pathogen by the World Health Organization. The increasing emergence of resistance to azole antifungals such as fluconazole highlights the need for alternative therapeutic strategies. In this study, we evaluated the antifungal potential of a chromium(III)\u2013triazole coordination complex (CrL1) against C. albicans. In vitro susceptibility testing showed that CrL1 exhibited notable antifungal activity against the fluconazole-resistant strain with low cytotoxicity in murine macrophages. To facilitate aqueous dispersion and enable in vivo administration, CrL1 was incorporated into an oil-in-water nanoemulsion (NE-CrL1). The antifungal activity of NE-CrL1 was evaluated in a murine model of invasive candidiasis. In mice infected with a fluconazole-resistant C. albicans strain, treatment with NE-CrL1 reduced renal fungal burden and was associated with attenuation of histopathological alterations and changes in local inflammatory responses. Although the present study has limitations, including the absence of mechanistic assays and additional physicochemical characterization, these results suggest in vivo antifungal activity of NE-CrL1 and warrant further preclinical evaluation against drug-resistant Candida infections.<\/jats:p>","DOI":"10.3390\/jof12060403","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T11:25:31Z","timestamp":1780399531000},"page":"403","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["In Vivo Evaluation of a Nanoemulsion-Delivered Chromium(III)\u2013Triazole Complex Against Fluconazole-Resistant Candida albicans"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4840-9158","authenticated-orcid":false,"given":"Maria Valentina","family":"Bedoya-Florez","sequence":"first","affiliation":[{"name":"Medical and Experimental Mycology Group CIB-UPB-UdeA-UDES, Medell\u00edn 050036, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo A.","family":"Murcia-Gal\u00e1n","sequence":"additional","affiliation":[{"name":"Research Group in Inorganic Chemistry, Catalysis, and Bioinorganic, Department of Chemistry, University of the Andes, Carrera 1 18A-12, Bogot\u00e1 111711, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4588-0681","authenticated-orcid":false,"given":"Martha Viviana","family":"Roa-Cordero","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Masira, Facultad de Ciencias M\u00e9dicas y de la Salud, Universidad de Santander, Bucaramanga 680002, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0120-8060","authenticated-orcid":false,"given":"Sandra M.","family":"Leal-Pinto","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Masira, Facultad de Ciencias M\u00e9dicas y de la Salud, Universidad de Santander, Bucaramanga 680002, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6000-2348","authenticated-orcid":false,"given":"Juan David","family":"Puerta-Arias","sequence":"additional","affiliation":[{"name":"Medical and Experimental Mycology Group CIB-UPB-UdeA-UDES, Medell\u00edn 050036, Colombia"},{"name":"Instituto de Investigaci\u00f3n Masira, Facultad de Ciencias M\u00e9dicas y de la Salud, Universidad de Santander, Bucaramanga 680002, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7001-3358","authenticated-orcid":false,"given":"Yair","family":"Alvarez-Ricardo","sequence":"additional","affiliation":[{"name":"Research Group in Inorganic Chemistry, Catalysis, and Bioinorganic, Department of Chemistry, University of the Andes, Carrera 1 18A-12, Bogot\u00e1 111711, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0511-9719","authenticated-orcid":false,"given":"John J.","family":"Hurtado","sequence":"additional","affiliation":[{"name":"Research Group in Inorganic Chemistry, Catalysis, and Bioinorganic, Department of Chemistry, University of the Andes, Carrera 1 18A-12, Bogot\u00e1 111711, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4667-6391","authenticated-orcid":false,"given":"Tonny W.","family":"Naranjo","sequence":"additional","affiliation":[{"name":"Medical and Experimental Mycology Group CIB-UPB-UdeA-UDES, Medell\u00edn 050036, Colombia"},{"name":"School of Health Sciences, Universidad Pontificia Bolivariana, Medell\u00edn 050031, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"143","DOI":"10.15698\/mic2020.06.718","article-title":"Fungal infections in humans: The silent crisis","volume":"7","author":"Kainz","year":"2020","journal-title":"Microb. 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