{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T02:57:10Z","timestamp":1781233030846,"version":"3.54.1"},"reference-count":31,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>Candidemia is a major healthcare-associated bloodstream infection with high mortality, requiring ongoing surveillance to guide management. This retrospective study analyzed 306 candidemia episodes diagnosed between 2015 and 2024 at a Spanish tertiary-care hospital, comparing two periods (2015\u20132019 vs. 2020\u20132024). The overall incidence was 0.79 episodes per 1.000 admissions, with peaks in 2021 and 2024. Candida albicans was the most common species (44.8%), followed by Candida parapsilosis (19.0%) and Nakaseomyces glabrata (15.7%). A significant epidemiological shift occurred in the later period, with increased C. albicans, decreased C. parapsilosis, and emergence of N. glabrata as the second-most frequent species. ICU-related cases rose significantly during the COVID-19 period. Diagnostic turnaround times improved, including faster blood culture positivity and species identification by MALDI-TOF, supported by rapid PCR testing with high sensitivity (91.7%). Antifungal resistance to fluconazole was notable in N. glabrata (48.1%). Empirical echinocandin use increased, alongside greater targeted fluconazole therapy. Antimicrobial stewardship interventions, mainly de-escalation strategies, were widely implemented after 2019. Overall mortality was 40.8%, with a decline observed in 2023\u20132024. These findings suggest that integrated diagnostic and stewardship strategies may improve outcomes, though causal relationships require further study.<\/jats:p>","DOI":"10.3390\/jof12060428","type":"journal-article","created":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T01:52:08Z","timestamp":1781229128000},"page":"428","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ten-Year Trends in Candidemia at a Tertiary-Care Hospital in Spain (2015\u20132024): Epidemiological Shifts, Diagnostic Acceleration, and Impact of Antifungal Stewardship in the COVID-19 and Post-Pandemic Era"],"prefix":"10.3390","volume":"12","author":[{"given":"Cristian","family":"Castell\u00f3-Abietar","sequence":"first","affiliation":[{"name":"Microbiology Department, Hospital Universitario Central de Asturias, 33001 Oviedo, Spain"},{"name":"Microbiology and Infectious Diseases Group, Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA), 33001 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Alaguero","sequence":"additional","affiliation":[{"name":"Clinical Pharmacy Management Department, Hospital Universitario Central de Asturias, 33011 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Garc\u00eda-Car\u00fas","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hospital Universitario Central de Asturias, 33011 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2011-3059","authenticated-orcid":false,"given":"Emilio","family":"Garc\u00eda-Prieto","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Hospital Universitario Central de Asturias, 33011 Oviedo, Spain"},{"name":"Grupo Investigaci\u00f3n Traslacional en el Paciente Cr\u00edtico, Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA), 33011 Oviedo, Spain"},{"name":"CIBER of Respiratory Diseases (CIBERES), ISCIII, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Bola\u00f1os","sequence":"additional","affiliation":[{"name":"Microbiology Department, Hospital Universitario Central de Asturias, 33001 Oviedo, Spain"},{"name":"Microbiology and Infectious Diseases Group, Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA), 33001 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Fern\u00e1ndez-Su\u00e1rez","sequence":"additional","affiliation":[{"name":"Microbiology Department, Hospital Universitario Central de Asturias, 33001 Oviedo, Spain"},{"name":"Microbiology and Infectious Diseases Group, Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA), 33001 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa Pel\u00e1ez Garc\u00eda","family":"de la Rasilla","sequence":"additional","affiliation":[{"name":"Microbiology Department, Hospital Universitario Central de Asturias, 33001 Oviedo, Spain"},{"name":"Microbiology and Infectious Diseases Group, Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA), 33001 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"18026","DOI":"10.1038\/nrdp.2018.26","article-title":"Invasive candidiasis","volume":"4","author":"Pappas","year":"2018","journal-title":"Nat. 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