{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T20:45:37Z","timestamp":1789591537251,"version":"build-2803163510"},"reference-count":38,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>Background: Candidemia remains a significant public health challenge, with increasing resistance. Contemporary post-pandemic data from high-complexity Latin American hospitals are scarce. Methods: A retrospective study (2022\u20132023) was conducted in adults with candidemia at a high-complexity Colombian university hospital. Species identification and susceptibility were analyzed using VITEK\u00ae 2 and Clinical and Laboratory Standards Institute (CLSI) criteria. Survival was estimated using Kaplan\u2013Meier analysis. Results: Of 3483 blood cultures, 109 episodes were identified. The incidence was 1.13\/1000 admissions (5.96\/1000 in the Intensive care unit\u2014ICU). Species other than Candida albicans predominated (61.5%), mainly C. tropicalis (22.9%) and C. parapsilosis (22.0%). Alarmingly, 28.6% of C. parapsilosis isolates were resistant to fluconazole. Consultation with an infectious diseases service was performed in 72.5% of cases, with a significantly higher rate among survivors (p &lt; 0.05). Overall mortality was 52.3%, while 30-day mortality reached 42.2%. ICU patients had a cumulative mortality rate of 50% by day 30. Conclusions: Post-pandemic candidemia shows shifting species and high resistance. Key priorities include expert infectious disease consultation to optimize outcomes in non-neutropenic patients and strengthening laboratory capacity for identification and susceptibility testing to monitor rising resistance and guide effective institutional antifungal policies.<\/jats:p>","DOI":"10.3390\/jof12070457","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T01:03:23Z","timestamp":1782263003000},"page":"457","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Shift in Candidemia Epidemiology and Emerging Fluconazole Resistance in Candida parapsilosis: A Post-Pandemic Cohort Study in a Colombian High-Complexity Teaching Hospital"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9281-2844","authenticated-orcid":false,"given":"Jenny Patricia","family":"Mu\u00f1oz-Lombo","sequence":"first","affiliation":[{"name":"Infectious Diseases Department, Hospital Universitario del Valle \u201cEvaristo Garc\u00eda\u201d, Cali 760043, Colombia"},{"name":"Infectious Diseases Department, Universidad del Valle, Cali 760043, Colombia"},{"name":"Internal Medicine Department, Universidad del Valle, Cali 760043, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8943-0137","authenticated-orcid":false,"given":"William David","family":"Cardales-Arizal","sequence":"additional","affiliation":[{"name":"Pathology Department, Universidad del Valle, Cali 760043, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0692-5077","authenticated-orcid":false,"given":"Ra\u00fal Andr\u00e9s","family":"Vallejo-Serna","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, Universidad del Valle, Cali 760043, Colombia"},{"name":"Internal Medicine Department, Universidad del Valle, Cali 760043, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indira","family":"Berrio","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, Hospital General de Medell\u00edn, Medell\u00edn 050015, Colombia"},{"name":"Basic and Applied Microbiology Research Group (MICROBA), School of Microbiology, Universidad de Antioquia, Medell\u00edn 050010, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"165rv13","DOI":"10.1126\/scitranslmed.3004404","article-title":"Hidden killers: Human fungal infections","volume":"4","author":"Brown","year":"2012","journal-title":"Sci. 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