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Fungi","JoF"],"abstract":"<jats:p>Gastrodia elata, a medicinal and edible plant of the Orchidaceae family, has a long history of medicinal application and extensive development value in China. Endophytes permanently colonize G. elata and form a stable long-term symbiotic relationship with the host. The secondary metabolites produced by these fungi possess diverse structures and multiple biological activities, which are important sources for discovering novel bioactive ingredients that provide natural materials for screening and developing medicinal compounds. This article reviewed the research and development progress of endophytes associated with G. elata, including endophytes\u2019 sources, biological functions, compound classification and pharmacological activities. The results showed that more than 296 secondary metabolites were reported\u2014mainly terpenoids, polyketides, alkaloids, anthraquinones, phenolics\u2014with prominently characterized antifeedant and antibacterial activities. Our work aims to provide scientific references for the in-depth exploration and efficient utilization of G. elata endophytic fungal resources.<\/jats:p>","DOI":"10.3390\/jof12080614","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T12:01:26Z","timestamp":1786968086000},"page":"614","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Research Advances in Gastrodia elata Endophytes: Diversity, Secondary Metabolites and Pharmacological Activities"],"prefix":"10.3390","volume":"12","author":[{"given":"Tianzhen","family":"Xie","sequence":"first","affiliation":[{"name":"College of Chemistry and Chemical Engineering, Zhaotong University, Zhaotong 657000, China"},{"name":"Yunnan Key Laboratory of Gastrodia and Fungi Symbiotic Biology of Yunnan Province, Zhaotong University, Zhaotong 657000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0441-4257","authenticated-orcid":false,"given":"Kaize","family":"Shen","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering, Zhaotong University, Zhaotong 657000, China"},{"name":"Yunnan Key Laboratory of Gastrodia and Fungi Symbiotic Biology of Yunnan Province, Zhaotong University, Zhaotong 657000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjian","family":"Xia","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering, Zhaotong University, Zhaotong 657000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyun","family":"Tan","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering, Zhaotong University, Zhaotong 657000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Congjia","family":"Xie","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering, Zhaotong University, Zhaotong 657000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengbiao","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering, Zhaotong University, Zhaotong 657000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4054-4286","authenticated-orcid":false,"given":"Zhilong","family":"Shi","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering, Zhaotong University, Zhaotong 657000, China"},{"name":"Yunnan Key Laboratory of Gastrodia and Fungi Symbiotic Biology of Yunnan Province, Zhaotong University, Zhaotong 657000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8361-9877","authenticated-orcid":false,"given":"Xin","family":"Wei","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1080\/10408347.2024.2397994","article-title":"A Review of Gastrodia elata Bl.: Extraction, Analysis and Application of Functional Food","volume":"56","author":"Li","year":"2026","journal-title":"Crit. 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