{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T09:19:50Z","timestamp":1788254390469,"version":"build-2803163510"},"reference-count":90,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"CRC Tier 1 Chair in Translational Genomics"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Fungi","JoF"],"abstract":"<jats:p>Fungal mycoparasitism, where one fungus preys on another, offers a sustainable, eco-friendly alternative to synthetic chemical fungicides in agriculture and conventional antifungal therapies to manage clinical pathogens. The budding yeast Saccharomycopsis schoenii has emerged as a compelling model for contact-dependent, necrotrophic predation. Belonging to the CUG-Ser2 clade, its obligate predatory lifestyle is characterized by extensive genomic restructuring, including the loss of the sulfate assimilation pathway, which couples methionine starvation to a predatory behavioral switch. In this review, we highlight recent comparative genomics and functional studies as they relate to S. schoenii predation. For example, S. schoenii uses rewired mitogen-activated protein kinase (MAPK) signaling, actin-based penetration pegs and a large tandem expansion of secreted aspartic proteases (SAPs) to breach prey cell walls. Analysis of its genome reveals structural adaptations, including AT-rich regional centromeres and dispersed mating-type (MAT) loci. The more we learn about S. schoenii\u2019s contact-dependent attack, the greater the opportunities to deploy S. schoenii as a safe, mycotoxin-free biocontrol agent against both multi-drug-resistant Candida auris and post-harvest Penicillium molds.<\/jats:p>","DOI":"10.3390\/jof12090651","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T08:31:13Z","timestamp":1788251473000},"page":"651","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Saccharomycopsis schoenii: A Model Predatory Yeast Provides Insights into Evolution, Genomics and Biocontrol"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9357-5588","authenticated-orcid":false,"given":"Divya","family":"Kriti","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, University of British Columbia, 2350 Health Sciences Mall, Vancouver, BC V6T 1Z3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjan","family":"Barazandeh","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, University of British Columbia, 2405 Wesbrook Mall, Vancouver, BC V6T 1Z3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph Uche","family":"Ogbede","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, University of British Columbia, 2405 Wesbrook Mall, Vancouver, BC V6T 1Z3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guri","family":"Giaever","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, University of British Columbia, 2405 Wesbrook Mall, Vancouver, BC V6T 1Z3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4016-8874","authenticated-orcid":false,"given":"Corey","family":"Nislow","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, University of British Columbia, 2350 Health Sciences Mall, Vancouver, BC V6T 1Z3, Canada"},{"name":"Department of Pharmaceutical Sciences, University of British Columbia, 2405 Wesbrook Mall, Vancouver, BC V6T 1Z3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Chowdhary, A., Sharma, C., and Meis, J.F. 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