{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T11:18:54Z","timestamp":1788261534418,"version":"build-2803163510"},"reference-count":43,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32260655"],"award-info":[{"award-number":["32260655"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"award":["32260655"],"award-info":[{"award-number":["32260655"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Hainan Provincial Natural Science Foundation of China","award":["323MS060"],"award-info":[{"award-number":["323MS060"]}]},{"name":"Hainan Provincial Natural Science Foundation of China","award":["325MS100"],"award-info":[{"award-number":["325MS100"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Fungi","JoF"],"abstract":"<jats:p>Banana Fusarium wilt, caused by the soil-borne fungus Fusarium oxysporum f. sp. cubense (Foc), is a devastating disease and a major threat to global banana production. Here, we identified 24 genes predicted to encode heme-dependent peroxidase- or catalase\u2013peroxidase-related proteins in Foc race 4 (Foc4), whereas nine genes encoding thiol-dependent peroxide-reducing proteins were catalogued separately. Phylogenetic, synteny, and Ka\/Ks analyses indicated a conserved peroxidase repertoire under strong purifying selection, without substantial lineage-specific expansion. Motif, domain, gene-structure, and promoter analyses revealed subgroup-specific features and abundant putative stress- and hormone-responsive cis-regulatory motifs. Expression profiling during banana infection and H2O2 treatment showed distinct temporal and oxidative-stress responses. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses linked subsets of these genes to antioxidant activity, peroxide metabolism, peroxisomal functions, and stress signaling. A F. oxysporum f. sp. lycopersici ortholog-based interaction network combined with co-expression analysis prioritized five peroxidases potentially associated with pathogenicity-related expression programs. FoCP, selected separately based on its rapid H2O2 response and catalase\u2013peroxidase annotation, enhanced oxidative-stress tolerance when heterologously expressed in yeast. Overall, Foc4 appears to adapt to oxidative stress through condition-specific regulation of a conserved peroxidase repertoire rather than gene-family expansion. The network-prioritized peroxidases provide candidates for further functional and pathogenicity studies.<\/jats:p>","DOI":"10.3390\/jof12090653","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T10:32:18Z","timestamp":1788258738000},"page":"653","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genome-Wide Analysis of Fusarium oxysporum f. sp. cubense Peroxidases Reveals Oxidative-Stress Responses and Infection-Associated Expression"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2974-388X","authenticated-orcid":false,"given":"Zhaojian","family":"Ding","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, Qiongtai Normal University, Haikou 571127, China"},{"name":"Tropical Biodiversity and Bioresource Utilization Laboratory, Qiongtai Normal University, Haikou 571127, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Han","family":"Ouyang","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Qiongtai Normal University, Haikou 571127, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Qiongtai Normal University, Haikou 571127, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"}]},{"given":"Xinyi","family":"Lian","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Qiongtai Normal University, Haikou 571127, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"}]},{"given":"Huiqun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Qiongtai Normal University, Haikou 571127, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"}]},{"given":"Yangjiao","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Qiongtai Normal University, Haikou 571127, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"supervision","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6707-8562","authenticated-orcid":false,"given":"Huijiao","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Qiongtai Normal University, Haikou 571127, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"funding-acquisition","vocabulary":"credit"}]},{"given":"Qiyan","family":"Fu","sequence":"additional","affiliation":[{"name":"Tropical Agricultural College, Hainan College of Vocation and Technique, Haikou 570216, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"conceptualization","vocabulary":"credit"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Bubici, G., Kaushal, M., Prigigallo, M.I., Gomez-Lama Cabanas, C., and Mercado-Blanco, J. 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