{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T15:29:59Z","timestamp":1789658999972,"version":"4.0.1"},"reference-count":50,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Brazilian National Council for Scientific and Technological Development","id":[{"id":"https:\/\/ror.org\/03swz6y49","id-type":"ROR","asserted-by":"crossref"}]},{"id":[{"id":"https:\/\/ror.org\/03swz6y49","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Minas Gerais State Research Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Fungi","JoF"],"abstract":"<jats:p>Background: The zoonotic epidemic of sporotrichosis caused by Sporothrix brasiliensis has expanded throughout Brazil and other countries, with a rise in deep forms of disease. Detailed comparative data on the presentation, treatment and outcomes of cutaneous and deep disease are needed to follow how Brazilian cohorts are evolving. Methods: The study involves a retrospective observational cohort of patients with sporotrichosis treated at a quaternary university hospital in Belo Horizonte between 2011 and 2026, restricted to culture-positive cases. Localized cutaneous disease was compared with deep infection using logistic regression adjusted for age and sex. Results: Of 313 patients, 213 had a positive culture. The median age was 41 years, and 54.0% were women. Lymphocutaneous disease predominated (54.0%), and contact with cats was reported by 53.1%. The median treatment duration was 150 days. Among the 101 patients with a defined outcome, 97 were cured (96.0%), with no documented treatment failure. All four sporotrichosis-related deaths occurred in the deep infection group, which was independently associated with comorbidity (OR 9.69; 95% CI 2.52 to 37.23) and an immunosuppressive condition (OR 6.61; 95% CI 1.89 to 23.09). Conclusions: Localized cutaneous sporotrichosis was cured in nearly all the patients with documented follow-up, whereas mortality was confined to deep infection associated with comorbidities and immunosuppression.<\/jats:p>","DOI":"10.3390\/jof12090685","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T17:14:59Z","timestamp":1789146899000},"page":"685","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Localized Cutaneous Versus Deep Sporotrichosis at Hospital das Cl\u00ednicas, UFMG, Belo Horizonte, Brazil: A Cohort of 213 Culture-Confirmed Cases, 2011 to 2026"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9345-018X","authenticated-orcid":false,"given":"Helena","family":"Duani","sequence":"first","affiliation":[{"name":"Infectious Diseases Service, Department of Internal Medicine, Faculty of Medicine, Universidade Federal de Minas Gerais, UFMG, Belo Horizonte 30130-100, Minas Gerais, Brazil"},{"name":"Postgraduate Program in Infectious Diseases and Tropical Medicine, Faculty of Medicine, Universidade Federal de Minas Gerais, UFMG, Belo Horizonte 30130-100, Minas Gerais, 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