{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T09:11:40Z","timestamp":1789549900896,"version":"build-2803163510"},"reference-count":32,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014219","name":"National Science Fund for Distinguished Young Scholars","doi-asserted-by":"publisher","award":["82325047"],"award-info":[{"award-number":["82325047"]}],"id":[{"id":"10.13039\/501100014219","id-type":"DOI","asserted-by":"publisher"}]},{"award":["82325047"],"award-info":[{"award-number":["82325047"]}],"id":[{"id":"https:\/\/ror.org\/05eg49r29","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Regional Innovation and Development Joint Fund of NSFC","award":["U24A20807"],"award-info":[{"award-number":["U24A20807"]}]},{"name":"CAS \u201cLight of West China\u201d Program and CAS Interdisciplinary Innovation Team","award":["xbzg-zdsys-202303"],"award-info":[{"award-number":["xbzg-zdsys-202303"]}]},{"name":"Yunnan Revitalization Talent Support Program: Yunling Scholar Project"},{"DOI":"10.13039\/501100008871","name":"Yunnan Province Science and Technology Department","doi-asserted-by":"publisher","award":["202305AH340005"],"award-info":[{"award-number":["202305AH340005"]}],"id":[{"id":"10.13039\/501100008871","id-type":"DOI","asserted-by":"publisher"}]},{"award":["202305AH340005"],"award-info":[{"award-number":["202305AH340005"]}],"id":[{"id":"https:\/\/ror.org\/03whqdf70","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Fungi","JoF"],"abstract":"<jats:p>Arthrinium species are promising producers of terpenoids with diverse architectures and noteworthy pharmacological properties. In this work, ten undescribed terpestacin-type sesterterpenoids, arthritacins A\u2013J (1\u201310), together with five known analogues (11\u201315), were obtained from the endophytic fungus Arthrinium sp. HS66 isolated from the stems of Isodon xerophilus. Their structures were established through comprehensive spectroscopic analysis, semisynthesis, and NMR calculations, further supported by DP4+ probability analysis. The semisynthetic studies further helped confirm the biosynthetically ambiguous configurations at C-11 and C-23 in terpestacin derivatives. All compounds were evaluated for cytotoxic activity against human neuroblastoma cells. Among them, compounds 1, 2, 4, 6, 7, 9, 12 and 13 showed moderate antiproliferative effects, with IC50 values ranging from 21.13 to 36.54 \u00b5M.<\/jats:p>","DOI":"10.3390\/jof12090693","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T07:58:59Z","timestamp":1789545539000},"page":"693","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Discovery and Semisynthesis of Arthritacins A\u2013J\u2014Terpestacin-Derived Sesterterpenoids from the Plant Endophytic Fungus Arthrinium sp. HS66"],"prefix":"10.3390","volume":"12","author":[{"given":"Xiao-Zheng","family":"Su","sequence":"first","affiliation":[{"name":"State Key Laboratory of Phytochemistry and Natural Medicines, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China"},{"name":"Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"methodology","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"}]},{"given":"Kun","family":"Hu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Phytochemistry and Natural Medicines, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China"},{"name":"Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"methodology","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2454-4232","authenticated-orcid":false,"given":"Xing-Ren","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Phytochemistry and Natural Medicines, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China"},{"name":"Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"}]},{"given":"Han-Dong","family":"Sun","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Phytochemistry and Natural Medicines, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China"},{"name":"Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"resources","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5212-3000","authenticated-orcid":false,"given":"Pema-Tenzin","family":"Puno","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Phytochemistry and Natural Medicines, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China"},{"name":"Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1039\/c1np00030f","article-title":"Are we ready for industrial production of bioactive plant secondary metabolites utilizing endophytes?","volume":"28","author":"Kusari","year":"2011","journal-title":"Nat. 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