{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T17:04:20Z","timestamp":1789578260093,"version":"build-2803163510"},"reference-count":36,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Fungi","JoF"],"abstract":"<jats:p>Candida species are the leading cause of invasive fungal infections in children and are associated with substantial morbidity and mortality. We conducted a multicenter retrospective study across nine hospitals in Israel, including all candidemia episodes in patients aged 0\u201318 years between 2010 and 2022. Clinical, microbiological, and outcome data were collected, and multivariable logistic regression was used to identify predictors of 30-day mortality. A total of 498 candidemia episodes were identified in 482 patients. Most episodes occurred in immunocompromised children or those admitted to intensive care units. Non-albicans Candida species predominated (63.3%), although C. albicans remained the single most common species (36.7%). The most frequent non-albicans species were C. parapsilosis (25.5%), C. tropicalis (15.9%), and C. glabrata (9.6%). No cases of C. auris were identified. Fluconazole non-susceptibility was observed in 19.4% of isolates and increased from 15.5% during 2010\u20132016 to 23.3% during 2017\u20132022 (OR 2.89, 95% CI 1.45\u20135.11, p = 0.007). The 30-day mortality rate was 23.4%. Independent predictors of mortality included liver disease, neutropenia, total parenteral nutrition, urinary tract infection, skin lesions, and peritonitis. Pediatric candidemia remains associated with considerable mortality, while increasing fluconazole non-susceptibility among non-albicans Candida species highlights the need for ongoing surveillance and antifungal stewardship.<\/jats:p>","DOI":"10.3390\/jof12090695","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T16:07:29Z","timestamp":1789574849000},"page":"695","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Epidemiology, Species Susceptibility, and Mortality Risk Factors of Pediatric Candidemia: A 13-Year Multicenter Study"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1865-3283","authenticated-orcid":false,"given":"Elias","family":"Nasrallah","sequence":"first","affiliation":[{"name":"Pediatric Infectious Diseases Unit, Rappaport Children\u2019s Hospital, Rambam Health Care Campus, P.O. Box 9602, Haifa 3109601, Israel"},{"name":"The Azrieli Faculty of Medicine, Bar-Ilan University, Safed 1311502, Israel"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6923-1806","authenticated-orcid":false,"given":"Avi","family":"Magid","sequence":"additional","affiliation":[{"name":"Hospital Management, Rambam Health Care Campus, Haifa 3109601, Israel"},{"name":"Department of International Health, Maastricht University, P.O. Box 616, 6200MD Maastricht, The Netherlands"},{"name":"School of Public Health, Ben-Gurion University, Be\u2019er Sheva 8410501, Israel"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Michal","family":"Stein","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Disease Unit, The Edmond and Lily Safra Children\u2019s Hospital, Chaim Sheba Medical Centre, Ramat Gan 52621, Israel"},{"name":"Gray Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv 69978, Israel"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"}]},{"given":"Elina","family":"Gelman","sequence":"additional","affiliation":[{"name":"Pediatric 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