{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T12:15:18Z","timestamp":1790079318476,"version":"4.0.1"},"reference-count":23,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Fungi","JoF"],"abstract":"<jats:p>Azole resistance in Aspergillus fumigatus is an emerging threat to invasive and chronic aspergillosis management, yet multicenter trend analyses rarely verify whether the composition of surveillance data remained stable over time. We performed a longitudinal, secondary-data analysis of 2111 Aspergillus isolates registered in the VIVLI AMR platform (ATLAS Antifungals, SENTRY Program) between 2010 and 2020. Because Clinical and Laboratory Standards Institute (CLSI) voriconazole breakpoints are established only for A. fumigatus in this dataset, the susceptibility-trend analysis was restricted to A. fumigatus isolates with a valid interpretation (n = 1482\/1483). A. fumigatus accounted for 70.3% of all Aspergillus isolates; most originated from Europe (43.9%) and North America (35.2%). Region and clinical specialty differed significantly across the three study periods (both p &lt; 0.0001), while species, age, sex and specimen-source distributions remained stable (p &gt; 0.10). Voriconazole susceptibility in A. fumigatus declined from 97.9% (2010) to 90.4% (2020), with a significant linear downward trend (Cochran\u2013Armitage Z = \u22123.03, p = 0.002). This decline was statistically robust, but the concurrent shift in participating regions and specialties indicates that compositional changes in surveillance sampling should be considered alongside biological resistance emergence when interpreting multicenter antifungal surveillance trends.<\/jats:p>","DOI":"10.3390\/jof12090699","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T11:09:35Z","timestamp":1790075375000},"page":"699","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ten-Year Voriconazole Susceptibility Trends Among 1482 Clinical Aspergillus fumigatus Isolates: A Compositionally Controlled Multicenter Analysis of the VIVLI\/SENTRY Platform (2010\u20132020)"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0614-7284","authenticated-orcid":false,"given":"Jose W.","family":"Lopez","sequence":"first","affiliation":[{"name":"Facultad de Ciencias de la Salud, Universidad Cient\u00edfica del Sur, Lima 15067, Peru"},{"name":"Instituto Nacional de Salud del Ni\u00f1o San Borja, Lima 15037, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1731-6018","authenticated-orcid":false,"given":"Alicia A.","family":"Segura-Grados","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias de la Salud, Universidad Cient\u00edfica del Sur, Lima 15067, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5756-8381","authenticated-orcid":false,"given":"Emily","family":"Olascoaga-Mori","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias de la Salud, Universidad Cient\u00edfica del Sur, Lima 15067, Peru"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"data-curation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3575-4411","authenticated-orcid":false,"given":"Harold J.","family":"Rodr\u00edguez-Madue\u00f1o","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias de la Salud, Universidad Cient\u00edfica del Sur, Lima 15067, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"dlaf219","DOI":"10.1093\/jacamr\/dlaf219","article-title":"Global epidemiology of azole resistance in Aspergillus fumigatus","volume":"8","author":"Fengler","year":"2026","journal-title":"JAC-Antimicrob. 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