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Currently available therapies are decades old and may be impacted by drug resistance. Therefore, the need for more effective antifungal drugs for cryptococcosis is evident. A number of Cryptococcus virulence factors have been studied in detail, providing crucial information about the fungal biology and putative molecular targets for antifungals. This review focuses on the use of well-described virulence factors of Cryptococcus as potential anticryptococcal agents.<\/jats:p>","DOI":"10.3390\/jof2040029","type":"journal-article","created":{"date-parts":[[2016,11,30]],"date-time":"2016-11-30T10:10:36Z","timestamp":1480500636000},"page":"29","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Virulence Factors as Targets for Anticryptococcal Therapy"],"prefix":"10.3390","volume":"2","author":[{"given":"Renata","family":"Azevedo","sequence":"first","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz\u2014Fiocruz, Centro de Desenvolvimento Tecnol\u00f3gico em Sa\u00fade (CDTS), 21040-361 Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Rizzo","sequence":"additional","affiliation":[{"name":"Instituto de Microbiologia Paulo de G\u00f3es (IMPG), Universidade Federal do Rio de Janeiro, 21941-902 Rio de Janeiro, Brazil"},{"name":"Instituto de Bioqu\u00edmica M\u00e9dica (IBqM), Universidade Federal do Rio de Janeiro, 21941-902 Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcio","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz\u2014Fiocruz, Centro de Desenvolvimento Tecnol\u00f3gico em Sa\u00fade (CDTS), 21040-361 Rio de Janeiro, Brazil"},{"name":"Instituto de Microbiologia Paulo de G\u00f3es (IMPG), Universidade Federal do Rio de Janeiro, 21941-902 Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2016,11,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"165rv13","DOI":"10.1126\/scitranslmed.3004404","article-title":"Hidden killers: Human fungal infections","volume":"4","author":"Brown","year":"2012","journal-title":"Sci. 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