{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T17:31:58Z","timestamp":1787679118259,"version":"build-2784847793"},"reference-count":48,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>The passive and voluntary surveillance of cryptococcosis in Colombia since 1997 has seen an increasing participating rate, revealing its importance to both in immunosuppressed and immunocompetent people. The present work details the national data gathered in 1997\u20132016, through a retrospective analysis of the information collected in the survey. From a total of 1974 cases reported, an overall incidence of 0.23 cases per 100,000 people was found. This incidence rose to 1.1 cases per 1000 people in the Acquired Immunodeficiency Syndrome (AIDS) population. Cryptococcosis was most common in male young adults (26\u201340 years), with a male:female ratio of 3.9:1 in the general population and 5.4:1 in Human Immunodeficiency Virus (HIV) patients. Culture was the most common form of diagnosis in 96.3% of cases, recovering C. neoformans species in 87.5% and C. gattii in 3.1% of samples. VNI was the most prevalent (96.1%) molecular type, while VGII predominated in C. gattii isolates (54.3%). Early mortality was reported as the outcome in 47.5% of patients. Cryptococcosis remains an important opportunistic disease in Colombia and is gaining status as a primary pathogen in apparently immunocompetent patients. Our findings show the importance of including cryptococcosis as a notifiable disease, which will allow for improving opportune diagnosis and treatment, resulting in better patient outcomes.<\/jats:p>","DOI":"10.3390\/jof4010032","type":"journal-article","created":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T12:15:44Z","timestamp":1519906544000},"page":"32","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Cryptococcosis in Colombia: Compilation and Analysis of Data from Laboratory-Based Surveillance"],"prefix":"10.3390","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3029-118X","authenticated-orcid":false,"given":"Patricia","family":"Escand\u00f3n","sequence":"first","affiliation":[{"name":"Grupo de Microbiolog\u00eda, Instituto Nacional de Salud, Bogot\u00e1 111321, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jairo","family":"Lizarazo","sequence":"additional","affiliation":[{"name":"Departamento de Medicina Interna, Hospital Universitario Erasmo Meoz, Universidad de Pamplona, C\u00facuta 540018, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Agudelo","sequence":"additional","affiliation":[{"name":"Grupo de Microbiolog\u00eda, Instituto Nacional de Salud, Bogot\u00e1 111321, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Casta\u00f1eda","sequence":"additional","affiliation":[{"name":"Grupo de Microbiolog\u00eda, Instituto Nacional de Salud, Bogot\u00e1 111321, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,3,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Kwon-Chung, K.J., Bennett, J.E., Wickes, B.L., Meyer, W., Cuomo, C.A., Wollenburg, K.R., Bicanic, T.A., Casta\u00f1eda, E., Chang, Y.C., and Chen, J. (2017). The Case for Adopting the \u201cSpecies Complex\u201d Nomenclature for the Etiologic Agents of Cryptococcosis. mSphere, 11.","DOI":"10.1128\/mSphere.00357-16"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.fgb.2015.02.009","article-title":"Recognition of seven species in the Cryptococcus gattii\/Cryptococcus neoformans species complex","volume":"78","author":"Hagen","year":"2015","journal-title":"Fungal Genet. Biol."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Aminnejad, M., Cogliati, M., Duan, S., Arabatzis, M., Tintelnot, K., Casta\u00f1eda, E., Laz\u00e9ra, M., Velegraki, A., Ellis, D., and Sorrell, T.C. (2016). Identification and Characterization of VNI\/VNII and Novel VNII\/VNIV Hybrids and Impact of Hybridization on Virulence and Antifungal Susceptibility Within the, C. neoformans\/C. gattii Species Complex. PLoS ONE, 20.","DOI":"10.1371\/journal.pone.0163955"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"94","DOI":"10.7705\/biomedica.v27i1.236","article-title":"Estudio cl\u00ednico y epidemiol\u00f3gico de la criptococosis en Colombia: Resultado de nueve a\u00f1os de la encuesta nacional, 1997\u20132005","volume":"27","author":"Lizarazo","year":"2007","journal-title":"Biom\u00e9dica"},{"key":"ref_5","first-page":"386","article-title":"Cryptococosis in Colombia: Results of the national surveillance program for the years 2006\u20132010","volume":"32","author":"Lizarazo","year":"2012","journal-title":"Biom\u00e9dica"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1007\/s11908-017-0592-7","article-title":"Opportunistic Invasive Mycoses in AIDS: Cryptococcosis, Histoplasmosis, Coccidiodomycosis, and Talaromycosis","volume":"19","author":"Chastain","year":"2017","journal-title":"Curr. Infect. Dis. Rep."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/S1473-3099(17)30243-8","article-title":"Global burden of disease of HIV-associated cryptococcal meningitis: An updated analysis","volume":"17","author":"Rajasingham","year":"2017","journal-title":"Lancet Infect. Dis."},{"key":"ref_8","first-page":"4","article-title":"Epidemiological working groups of ECMM","volume":"2","author":"Viviani","year":"1997","journal-title":"Mycol. Newslett."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1186\/1757-1626-2-170","article-title":"Disseminated cryptococcosis with meningitis, peritonitis, and cryptococcemia in a HIV-negative patient with cirrhosis: A case report","volume":"28","author":"Yehia","year":"2009","journal-title":"Cases J."},{"key":"ref_10","unstructured":"(2017, September 10). Proyecciones de Poblaci\u00f3n, Available online: http:\/\/www.dane.gov.co\/index.php\/estadisticas-por-tema\/demografia-y-poblacion\/proyecciones-de-poblacion."},{"key":"ref_11","unstructured":"(2018, January 25). Panorama del VIH\/sida en Colombia 1983\u20132010. Available online: http:\/\/colombia.unfpa.org\/sites\/default\/files\/pub-pdf\/PANORAMA-VIH-SIDA-COLOMBIA-1983-2010.pdf."},{"key":"ref_12","unstructured":"(2018, January 25). Country Fact Sheets-Colombia 2016. Available online: http:\/\/www.unaids.org\/es\/regionscountries\/countries\/colombia."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"131","DOI":"10.7705\/biomedica.v14i3.2096","article-title":"Serotipificaci\u00f3n de aislamientos cl\u00ednicos y del medio ambiente de Cryptococcus neoformans en Colombia","volume":"14","year":"1994","journal-title":"Biom\u00e9dica"},{"key":"ref_14","first-page":"535","article-title":"Improved diagnostic medium for separation of Cryptococcus neoformans var. neoformans (serotypes A and D) and Cryptococcus neoformans var. gattii (serotypes B and C)","volume":"5","author":"Polacheck","year":"1982","journal-title":"J. Clin. Microbiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1111\/j.1567-1364.2006.00055.x","article-title":"Molecular epidemiology of clinical and environmental isolates of the Cryptococcus neoformans species complex reveals a high genetic diversity and the presence of the molecular type VGII mating type a in Colombia","volume":"6","author":"Meyer","year":"2006","journal-title":"FEMS Yeast Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1080\/13693780902953886","article-title":"Consensus multi-locus sequence typing scheme for Cryptococcus neoformans and Cryptococcus gattii","volume":"47","author":"Meyer","year":"2009","journal-title":"Med. Mycol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/S1567-1356(03)00038-2","article-title":"Molecular typing of clinical and environmental Cryptococcus neoformans isolates in the Brazilian state Rio Grande do Soul","volume":"3","author":"Casali","year":"2003","journal-title":"FEMS Yeast Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2920","DOI":"10.1128\/JCM.37.9.2920-2926.1999","article-title":"Presence of \u03b1 and a Mating types in environmental and clinical collections of Cryptococcus neoformans var. gattii strains from Australia","volume":"37","author":"Halliday","year":"1999","journal-title":"J. Clin. Microbiol."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Lizarazo, J., Escand\u00f3n, P., Agudelo, C.I., Firacative, C., Meyer, W., and Casta\u00f1eda, E. (2014). Retrospective Study of the Epidemiology and Clinical Manifestations of Cryptococcus gattii Infections in Colombia from 1997 to 2011. PLoS Negl. Trop. Dis., 8.","DOI":"10.1371\/journal.pntd.0003272"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1080\/02681219880000531","article-title":"First isolation of Cryptococcus neoformans var. gattii, serotype C, from the environment in Colombia","volume":"36","author":"Callejas","year":"1998","journal-title":"Med. Mycol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"118","DOI":"10.7705\/biomedica.v31i1.342","article-title":"First environmental isolation of Cryptococcus gattii serotype B, from C\u00facuta, Colombia","volume":"31","author":"Firacative","year":"2011","journal-title":"Biom\u00e9dica"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1590\/0074-0276130537","article-title":"Cryptococcosis in Colombian children and literature review","volume":"109","author":"Lizarazo","year":"2014","journal-title":"Mem. Inst. Oswaldo Cruz."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s11908-016-0534-9","article-title":"Cryptococcal Disease in HIV-Infected Children","volume":"18","author":"Kao","year":"2016","journal-title":"Curr. Infect. Dis. Rep."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.prrv.2009.06.009","article-title":"Cryptococcosis in children","volume":"10","author":"Severo","year":"2009","journal-title":"Paediatr. Respir. Rev."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e334","DOI":"10.1016\/S1473-3099(17)30303-1","article-title":"Fungal infections in HIV\/AIDS","volume":"17","author":"Limper","year":"2017","journal-title":"Lancet Infect. Dis."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s11046-014-9755-3","article-title":"Epidemiology of invasive fungal infections in patients with acquired immunodeficiency syndrome at a reference hospital for infectious diseases in Brazil","volume":"178","author":"Atobe","year":"2014","journal-title":"Mycopathologia"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Shaheen, A.A., Somayaji, R., Myers, R., and Mody, C.H. (2017). Epidemiology and trends of cryptococcosis in the United States from 2000 to 2007: A population-based study. Int. J. STD AIDS, 1.","DOI":"10.1177\/0956462417732649"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Frola, C., Guelfand, L., Blugerman, G., Szyld, E., Kaufman, S., Cahn, P., Sued, O., and P\u00e9rez, H. (2017). Prevalence of cryptococcal infection among advanced HIV patients in Argentina using lateral flow immunoassay. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0178721"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1590\/S0036-46652003000600001","article-title":"Cryptococcosis a review of the Brazilian experience for the disease","volume":"45","author":"Pappalardo","year":"2003","journal-title":"Rev. Inst. Med. Trop. S\u00e3o Paulo"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Illnait-Zaragozi, M.T., Mart\u00ednez-Mach\u00edn, G.F., Fern\u00e1ndez-Andreu, C.M., Perurena-Lancha, M.R., Hagen, F., and Meis, J.F. (2014). Cryptococcus and cryptococcosis in Cuba. A minireview. Mycoses, 57707\u201357717.","DOI":"10.1111\/myc.12275"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1086\/313992","article-title":"Epidemiology and host- and variety-dependent characteristics of infection due to Cryptococcus neoformans in Australia and New Zealand. Australasian Cryptococcal Study Group","volume":"31","author":"Chen","year":"2000","journal-title":"Clin. Infect. Dis."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1007\/s40588-017-0064-8","article-title":"Cryptococcosis Today: It Is Not All About HIV Infection","volume":"4","author":"Powderly","year":"2017","journal-title":"Curr. Clin. Microbiol. Rep."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Molloy, S.F., Chiller, T., Greene, G.S., Burry, J., Govender, N.P., Kanyama, C., Mfinanga, S., Lesikari, S., Mapoure, Y.N., and Kouanfack, C. (2017). Cryptococcal meningitis: A neglected NTD?. PLoS Negl. Trop. Dis., 11.","DOI":"10.1371\/journal.pntd.0005575"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0123-9392(12)70038-3","article-title":"Protocolo de estudio y manejo de los pacientes con criptococosis","volume":"16","author":"Lizarazo","year":"2012","journal-title":"Infectio"},{"key":"ref_35","unstructured":"Chetchotisakd, P., Kumarasamy, N., Govender, N., Lynen, L., Harrison, T., Meintjes, G., Horvath, T., Meyers, T., Kaplan, J., Mohan, N., and World Health Organization (2011). Rapid Advice: Diagnosis, Prevention and Management of Cryptococcal Disease in HIV-Infected Adults, Adolescents and Children, World Health Organization."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Jarvis, J.N., Harrison, T.S., Lawn, S.D., Meintjes, G., Wood, R., and Cleary, S. (2013). Cost effectiveness of cryptococcal antigen screening as a strategy to prevent HIV-associated cryptococcal meningitis in South Africa. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0069288"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1016\/S0140-6736(15)60164-7","article-title":"Cryptococcal meningitis screening and community-based early adherence support reduces all-cause mortality among HIV- infected people initiating antiretroviral therapy with advanced disease: A randomised-controlled trial in Tanzania and Zambia","volume":"385","author":"Mfinanga","year":"2015","journal-title":"Lancet"},{"key":"ref_38","first-page":"453","article-title":"Diagn\u00f3stico temprano de criptococosis e histoplasmosis en personas con VIH\/sida, informe preliminar","volume":"7","author":"Lizarazo","year":"2002","journal-title":"IQEN"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"765","DOI":"10.3109\/13693786.2013.781692","article-title":"Evaluation of a rapid lateral flow immunoassay for the detection of cryptococcal antigen for the early diagnosis of cryptococcosis in HIV patients in Colombia","volume":"51","author":"Lizarazo","year":"2013","journal-title":"Med. Mycol."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"C\u00e1ceres, D.H., Zuluaga, A., Tabares, A.M., Chiller, T., Gonz\u00e1lez, A., and G\u00f3mez, B.L. (2017). Evaluation of a Cryptococcal antigen Lateral Flow Assay in serum and cerebrospinal fluid for rapid diagnosis of cryptococcosis in Colombia. Rev. Inst. Med. Trop. S\u00e3o Paulo, 59.","DOI":"10.1590\/s1678-9946201759076"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Cogliati, M. (2013). Global Molecular Epidemiology of Cryptococcus neoformans and Cryptococcus gattii: An Atlas of the Molecular Types. Scientica.","DOI":"10.1155\/2013\/675213"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.fgb.2016.01.003","article-title":"Multilocus sequence typing analysis reveals that Cryptococcus neoformans var. neoformans is a recombinant population","volume":"87","author":"Cogliati","year":"2016","journal-title":"Fungal Genet. Biol."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Heitman, J., Kozel, T.R., Kwon-Chung, K.J., Perfect, J.R., and Casadevall, A. (2011). Cryptococcosis in AIDS. Cryptococcus: From Human Pathogen to Model Yeast, ASM Press.","DOI":"10.1128\/9781555816858"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.ijid.2005.07.004","article-title":"Primary and opportunistic pathogens associated with meningitis in adults in Bangui, Central African Republic, in relation to human immunodeficiency virus seros-tatus","volume":"10","author":"Bekondi","year":"2006","journal-title":"Int. J. Infect. Dis."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1093\/clinids\/20.3.611","article-title":"Cryptococcal disease of the CNS in immunocompetent hosts: Influence of cryptococcal variety on clinical manifestations and outcome","volume":"20","author":"Mitchell","year":"1995","journal-title":"Clin. Infect. Dis."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"249","DOI":"10.4049\/jimmunol.1202707","article-title":"Cryptococcus gattii is killed by dendritic cells but evades adaptive immunity by failing to induce dendritic cell maturation","volume":"191","author":"Huston","year":"2013","journal-title":"J. Immunol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.jmii.2011.12.005","article-title":"Different presentations and outcomes between HIV-infected and HIV-uninfected patients with Cryptococcal meningitis","volume":"45","author":"Liao","year":"2012","journal-title":"J. Microbiol. Immunol. Infect."},{"key":"ref_48","first-page":"49","article-title":"Comparaci\u00f3n de los hallazgos cl\u00ednicos y de supervivencia entre pacientes VIH positivos y VIH negativos con criptococosis men\u00edngea en un hospital del tercer nivel","volume":"37","author":"Lizarazo","year":"2012","journal-title":"Acta Med. Colomb."}],"container-title":["Journal of Fungi"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2309-608X\/4\/1\/32\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T14:57:05Z","timestamp":1760194625000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2309-608X\/4\/1\/32"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,1]]},"references-count":48,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,3]]}},"alternative-id":["jof4010032"],"URL":"https:\/\/doi.org\/10.3390\/jof4010032","relation":{},"ISSN":["2309-608X"],"issn-type":[{"value":"2309-608X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,1]]}}}