{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:52:01Z","timestamp":1787028721303,"version":"build-2736575974"},"reference-count":54,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2018,10,15]],"date-time":"2018-10-15T00:00:00Z","timestamp":1539561600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>Many chronic lung diseases are characterized by the hypersecretion of mucus. In these conditions, the administration of mucoactive agents is often indicated as adjuvant therapy. N-acetylcysteine (NAC) is a typical example of a mucolytic agent. A retrospective review of patients with pulmonary aspergillosis treated at the National Aspergillosis Centre in Manchester, United Kingdom, with NAC between November 2015 and November 2017 was carried out. Six Caucasians with Aspergillus lung disease received NAC to facilitate clearance of their viscid bronchial mucus secretions. One patient developed immediate bronchospasm on the first dose and could not be treated. Of the remainder, two (33%) derived benefit, with increased expectoration and reduced symptoms. Continued response was sustained over 6\u20137 months, without any apparent toxicity. In addition, a systematic review of the literature is provided to analyze the utility of NAC in the management of respiratory conditions which have unresponsive bronchial obstruction as a feature.<\/jats:p>","DOI":"10.3390\/jof4040117","type":"journal-article","created":{"date-parts":[[2018,10,16]],"date-time":"2018-10-16T02:52:53Z","timestamp":1539658373000},"page":"117","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Nebulised N-Acetylcysteine for Unresponsive Bronchial Obstruction in Allergic Brochopulmonary Aspergillosis: A Case Series and Review of the Literature"],"prefix":"10.3390","volume":"4","author":[{"given":"Akaninyene","family":"Otu","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, College of Medical Sciences, University of Calabar, Calabar, Cross River State P.M.B. 1115, Nigeria"},{"name":"The National Aspergillosis Centre, 2nd Floor Education and Research Centre, Wythenshawe Hospital, Southmoor Road, Manchester M23 9LT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Langridge","sequence":"additional","affiliation":[{"name":"The National Aspergillosis Centre, 2nd Floor Education and Research Centre, Wythenshawe Hospital, Southmoor Road, Manchester M23 9LT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5626-2251","authenticated-orcid":false,"given":"David W.","family":"Denning","sequence":"additional","affiliation":[{"name":"The National Aspergillosis Centre, 2nd Floor Education and Research Centre, Wythenshawe Hospital, Southmoor Road, Manchester M23 9LT, UK"},{"name":"Faculty of Biology, Medicine and Health, The University of Manchester, and Manchester Academic Health Science Centre, Oxford Rd, Manchester M13 9PL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,10,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1365-2273.1986.tb00108.x","article-title":"Possible mechanisms of reduction of nasal mucociliary clearance in chronic sinusitis","volume":"11","author":"Majima","year":"1986","journal-title":"Clin. Otolaryngol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"825","DOI":"10.4187\/respcare.04087","article-title":"Aerosol medications for treatment of mucus clearance disorders","volume":"60","author":"Rubin","year":"2015","journal-title":"Respir. Care"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"859","DOI":"10.4187\/respcare.07520859","article-title":"Mucolytics, expectorants, and mucokinetic medications","volume":"52","author":"Rubin","year":"2007","journal-title":"Respir. Care"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1056\/NEJMoa043900","article-title":"A controlled trial of long-term inhaled hypertonic saline in patients with cystic fibrosis","volume":"354","author":"Elkins","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1164\/ajrccm.153.5.8630593","article-title":"Effect of hypertonic saline, amiloride, and cough on mucociliary clearance in patients with cystic fibrosis","volume":"153","author":"Robinson","year":"1996","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1164\/ajrccm.153.2.8564129","article-title":"Effect of rhDNase on airflow obstruction and mucociliary clearance in cystic fibrosis","volume":"153","author":"Laube","year":"1996","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1172\/JCI119138","article-title":"Sodium chloride increases ciliary transportability of cystic fibrosis and bronchiectasis sputum on the mucus depleted bovine trachea","volume":"99","author":"Willis","year":"1997","journal-title":"J. Clin. Investig."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1016\/j.rmed.2011.07.019","article-title":"Nebulised 7% hypertonic saline improves lung function and quality of life in bronchiectasis","volume":"105","author":"Kellett","year":"2011","journal-title":"Respir. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1056\/NEJMoa043891","article-title":"Mucus clearance and lung function in cystic fibrosis with hypertonic saline","volume":"354","author":"Donaldson","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"ref_10","first-page":"215","article-title":"Antioxidant activity of carbocysteine lysine salt monohydrate","volume":"43","author":"Pinamonti","year":"2001","journal-title":"Panminerva Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1159\/000195871","article-title":"Long-lasting effects on rheology and clearance of bronchial mucus after short term administration of high doses of carbocysteine lysine to patients with chronic bronchitis","volume":"57","author":"Braga","year":"1990","journal-title":"Respiration"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1378\/chest.70.4.506","article-title":"S-carboxymethyl-cysteine in the humidification of sputum and treatment of chronic airways disease","volume":"70","author":"Edwards","year":"1976","journal-title":"Chest"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/S0091-6749(95)70128-1","article-title":"Prominent neutrophilic inflammation in sputum from subjects with asthma exacerbation","volume":"95","author":"Fahy","year":"1995","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1164\/rccm.200705-664OC","article-title":"Cystic fibrosis pulmonary guidelines: Chronic medications for maintenance of lung health","volume":"176","author":"Flume","year":"2007","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"L1240","DOI":"10.1152\/ajplung.00206.2007","article-title":"Unfractionated heparin reduces the elasticity of sputum from patients with cystic fibrosis","volume":"293","author":"Shur","year":"2007","journal-title":"Am. J. Physiol.-Lung Cell. Mol. Physiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1023\/A:1024175629909","article-title":"Mucin production and composition is altered in dextran sulfate sodium-induced colitis in rats","volume":"48","author":"Faure","year":"2003","journal-title":"Dig. Dis. Sci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1164\/ajrccm.157.3.9703059","article-title":"Improved clearability of cystic fibrosis sputum with dextran treatment in vitro","volume":"157","author":"Feng","year":"1998","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1185\/030079907X219715","article-title":"Safety and efficacy of intravenous N-acetylcysteine for acetaminophen overdose: Analysis of the Hunter Area Toxicology Service (HATS) database","volume":"10","author":"Whyte","year":"2007","journal-title":"Curr. Med. Res. Opin."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.annemergmed.2007.06.014","article-title":"Clinical policy: Critical issues in the management of patients presenting to the emergency department with acetaminophen overdose","volume":"50","author":"Wolf","year":"2007","journal-title":"Ann. Emerg. Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.pharmthera.2013.09.006","article-title":"Existing and potential therapeutic uses for N-acetylcysteine: The need for conversion to intracellular glutathione for antioxidant benefits","volume":"141","author":"Rushworth","year":"2014","journal-title":"Pharmacol. Ther."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"41","DOI":"10.4329\/wjr.v2.i1.41","article-title":"High attenuation mucoid impaction in allergic bronchopulmonary aspergillosis","volume":"2","author":"Agarwal","year":"2010","journal-title":"World J. Radiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1148\/radiology.156.3.4023231","article-title":"Aspergillosis of the paranasal sinuses","volume":"156","author":"Kopp","year":"1985","journal-title":"Radiology"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1148\/radiology.169.2.3174990","article-title":"Fungal sinusitis: Diagnosis with CT and MR imaging","volume":"169","author":"Zinreich","year":"1988","journal-title":"Radiology"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1378\/chest.07-0808","article-title":"Clinical significance of hyperattenuating mucoid impaction in allergic bronchopulmonary aspergillosis: An analysis of 155 patients","volume":"132","author":"Agarwal","year":"2007","journal-title":"Chest"},{"key":"ref_25","first-page":"374","article-title":"High-attenuation mucous plugging in allergic bronchopulmonary aspergillosis","volume":"47","author":"Logan","year":"1996","journal-title":"Can. Assoc. Radiol. J."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1007\/s00247-007-0471-8","article-title":"High-attenuation mucus plugs on MDCT in a child with cystic fibrosis: Potential cause and differential diagnosis","volume":"37","author":"Morozov","year":"2007","journal-title":"Pediatr. Radiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/BF00339869","article-title":"Computed tomography of the human skeletal muscular system","volume":"17","author":"Bulcke","year":"1979","journal-title":"Neuroradiology"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1148\/radiol.2462070712","article-title":"Fleischner Society: Glossary of terms for thoracic imaging","volume":"246","author":"Hansell","year":"2008","journal-title":"Radiology"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1183\/16000617.00002215","article-title":"Influence of N-acetylcysteine on chronic bronchitis or COPD exacerbations: A meta-analysis","volume":"24","author":"Cazzola","year":"2015","journal-title":"Eur. Respir. Rev."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"351","DOI":"10.3109\/15412555.2013.858315","article-title":"Effect of high\/low dose N-acetylcysteine on chronic obstructive pulmonary disease: A systematic review and meta-analysis","volume":"11","author":"Shen","year":"2014","journal-title":"COPD"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.hrtlng.2016.12.004","article-title":"The effect of N-acetylcysteine on exacerbations of chronic obstructive pulmonary disease: A meta-analysis and systematic review","volume":"46","author":"Fowdar","year":"2017","journal-title":"Heart Lung"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Tam, J., Nash, E.F., Ratjen, F., Tullis, E., and Stephenson, E. (2013). Nebulized and oral thiol derivatives for pulmonary disease in cystic fibrosis. Cochrane Database Syst. Rev., 7.","DOI":"10.1002\/14651858.CD007168.pub3"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0149-2918(00)88479-9","article-title":"Efficacy of oral long-term N-acetylcysteine in chronic bronchopulmonary disease: A meta-analysis of published double-blind, placebo-controlled clinical trials","volume":"22","author":"Grandjean","year":"2000","journal-title":"Clin. Ther."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"123","DOI":"10.2165\/00003088-199120020-00004","article-title":"Clinical pharmacokinetics of N-acetylcysteine","volume":"20","author":"Holdiness","year":"1991","journal-title":"Clin. Pharmacokinet."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/BF01061422","article-title":"Pharmacokinetics and bioavailability of reduced and oxidized N.-acetylcysteine","volume":"34","author":"Olsson","year":"1988","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/BF00606662","article-title":"Pharmacokinetics of N-acetylcysteine in man","volume":"31","author":"Paulsen","year":"1986","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"ref_37","first-page":"73","article-title":"No penetration of orally administered N-acetylcysteine into bronchoalveolar lavage fluid","volume":"70","author":"Cotgreave","year":"1987","journal-title":"Eur. J. Respir. Dis."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/0007-0971(85)90046-4","article-title":"Effect of oral N-acetylcysteine on mucus clearance","volume":"79","author":"Millar","year":"1985","journal-title":"Br. J. Dis Chest"},{"key":"ref_39","first-page":"217","article-title":"Toxicological, pharmacokinetic and metabolic studies on acetylcysteine","volume":"111","author":"Bonanomi","year":"1980","journal-title":"Eur. J. Respir. Dis."},{"key":"ref_40","unstructured":"Braga, P.C., and Allegra, L. (1989). Drugs in Bronchial Mucology, Raven Press."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/cc1451","article-title":"Clinical review: Severe asthma","volume":"6","author":"Papiris","year":"2002","journal-title":"Crit. Care"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"327","DOI":"10.4103\/1658-354X.115323","article-title":"Bronchoscopy as a rescue therapy in patients with status asthmaticus: Two case reports and review of literature","volume":"7","author":"Khan","year":"2013","journal-title":"Saudi J. Anaesth."},{"key":"ref_43","first-page":"156","article-title":"Pulmonary lavage in a patient in status asthmaticus receiving mechanical ventilation: A case report","volume":"49","author":"Shridharani","year":"1982","journal-title":"Ann. Allergy"},{"key":"ref_44","first-page":"85","article-title":"Status Asthmaticus: Use of acetylcysteine during bronchoscopy and lavage to remove mucous plugs","volume":"50","author":"Millman","year":"1983","journal-title":"Ann. Allergy"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1007\/s001010050200","article-title":"The application of n-acetylcysteine as an antioxidant and mucolytic in mechanical ventilation in intensive care patients. A prospective, randomized, placebo-controlled, double-blind study","volume":"44","author":"Konrad","year":"1995","journal-title":"Anaesthesist"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0096-5588(20)31265-4","article-title":"Mucoid impaction of the bronchi","volume":"22","author":"Shaw","year":"1951","journal-title":"J. Thorac. Surg."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1513\/AnnalsATS.201211-111OT","article-title":"Beware of Gloved Fingers","volume":"10","author":"Shah","year":"2013","journal-title":"Ann. Am. Thorac. Soc."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1148\/rg.285075212","article-title":"Mucoid impactions: Finger-in-glove sign and other CT and radiographic Features","volume":"28","author":"Martinez","year":"2008","journal-title":"Radiographics"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0003-4975(10)66532-0","article-title":"Mucoid impaction of the bronchi","volume":"2","author":"Urschel","year":"1966","journal-title":"J. Soc. Thorac. Surg. Assoc."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Agarwal, R., Khan, A., Gupta, D., Aggarwal, A.N., Saxena, A.K., and Chakrabarti, A. (2007). An alternate method of classifying allergic bronchopulmonary aspergillosis based on high- attenuation mucus. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0015346"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1046\/j.1440-1673.2003.01192.x","article-title":"Case quiz. Thoracic CT illustrating hyperdense bronchial mucous plugging: Allergic bronchopulmonary aspergillosis","volume":"47","author":"Karunaratne","year":"2003","journal-title":"Australas. Radiol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"e138","DOI":"10.2741\/944","article-title":"Allergic bronchopulmonary and sinus aspergillosis: The roentgenologic spectrum","volume":"8","author":"Shah","year":"2003","journal-title":"Front. Biosci."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.rmed.2009.09.005","article-title":"Clinical significance of decline in serum IgE Levels in allergic bronchopulmonary aspergillosis","volume":"104","author":"Agarwal","year":"2010","journal-title":"Respir. Med."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1378\/chest.130.2.442","article-title":"Allergic bronchopulmonary aspergillosis: Lessons from 126 patients attending a chest clinic in north India","volume":"130","author":"Agarwal","year":"2006","journal-title":"Chest"}],"container-title":["Journal of Fungi"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2309-608X\/4\/4\/117\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T20:09:04Z","timestamp":1775246944000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2309-608X\/4\/4\/117"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,15]]},"references-count":54,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2018,12]]}},"alternative-id":["jof4040117"],"URL":"https:\/\/doi.org\/10.3390\/jof4040117","relation":{},"ISSN":["2309-608X"],"issn-type":[{"value":"2309-608X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,15]]}}}