{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:48:51Z","timestamp":1790516931187,"version":"4.1.0"},"reference-count":30,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2018,12,12]],"date-time":"2018-12-12T00:00:00Z","timestamp":1544572800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>Candidiasis is an opportunistic fungal infection with Candida albicans being the most frequently isolated species. Treatment of these infections is challenging due to resistance that can develop during therapy, and the limited number of available antifungal compounds. Given this situation, the aim of this study was to evaluate the antifungal activity of four thiazolylhydrazone compounds against C. albicans. Thiazolylhydrazone compounds 1, 2, 3, and 4 were found to exert antifungal activity, with MICs of 0.125\u201316.0 \u03bcg\/mL against C. albicans. The toxicity of the compounds was evaluated using human erythrocytes and yielded LC50 &gt; 64 \u03bcg\/mL. The compounds were further evaluated using the greater wax moth Galleria mellonella as an in vivo model. The compounds prolonged larval survival when tested between 5 and 15 mg\/kg, performing as well as fluconazole. Compound 2 was evaluated in murine models of oral and systemic candidiasis. In the oral model, compound 2 reduced the fungal load on the mouse tongue; and in the systemic model it reduced the fungal burden found in the kidney when tested at 10 mg\/kg. These results show that thiazolylhydrazones are an antifungal towards C. albicans with in vivo efficacy.<\/jats:p>","DOI":"10.3390\/jof4040134","type":"journal-article","created":{"date-parts":[[2018,12,12]],"date-time":"2018-12-12T10:54:26Z","timestamp":1544612066000},"page":"134","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Anti-Candida albicans Activity of Thiazolylhydrazone Derivatives in Invertebrate and Murine Models"],"prefix":"10.3390","volume":"4","author":[{"given":"Lana Ivone Barreto","family":"Cruz","sequence":"first","affiliation":[{"name":"Departamento de Microbiologia, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais, Avenida Presidente Ant\u00f4nio Carlos, 6627, Pampulha, Belo Horizonte\u2014Minas Gerais 31270-901, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa Ferreira Finamore","family":"Lopes","sequence":"additional","affiliation":[{"name":"Departamento de Microbiologia, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais, Avenida Presidente Ant\u00f4nio Carlos, 6627, Pampulha, Belo Horizonte\u2014Minas Gerais 31270-901, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe","family":"De Camargo Ribeiro","sequence":"additional","affiliation":[{"name":"Departamento de Bioci\u00eancias e Diagn\u00f3stico Bucal, Instituto de Ci\u00eancia e Tecnologia de S\u00e3o Jos\u00e9 dos Campos\u2014UNESP, Av. Francisco Jos\u00e9 Longe, 777, Jardim S\u00e3o Dimas, S\u00e3o Jos\u00e9 dos Campos\u2014S\u00e3o Paulo 12245-000, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00edvea Pereira","family":"De S\u00e1","sequence":"additional","affiliation":[{"name":"Departamento de Microbiologia, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais, Avenida Presidente Ant\u00f4nio Carlos, 6627, Pampulha, Belo Horizonte\u2014Minas Gerais 31270-901, Brasil"},{"name":"Department of Molecular Genetics and Microbiology, Division of Infectious Diseases, Stony Brook University, 150 Life Science Building, Stony Brook, NY 11794, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cleudiomar In\u00e1cio","family":"Lino","sequence":"additional","affiliation":[{"name":"Departamento de Produtos Farmac\u00eauticos, Faculdade de Farm\u00e1cia, Universidade Federal de Minas Gerais, Belo Horizonte\u2014Minas Gerais 31270-901, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6107-3754","authenticated-orcid":false,"given":"Nagendran","family":"Tharmalingam","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Rhode Island Hospital, Alpert Medical School, and Brown University, Providence, RI 02903, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata Barbosa","family":"De Oliveira","sequence":"additional","affiliation":[{"name":"Departamento de Produtos Farmac\u00eauticos, Faculdade de Farm\u00e1cia, Universidade Federal de Minas Gerais, Belo Horizonte\u2014Minas Gerais 31270-901, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Augusto","family":"Rosa","sequence":"additional","affiliation":[{"name":"Departamento de Microbiologia, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais, Avenida Presidente Ant\u00f4nio Carlos, 6627, Pampulha, Belo Horizonte\u2014Minas Gerais 31270-901, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleftherios","family":"Mylonakis","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Rhode Island Hospital, Alpert Medical School, and Brown University, Providence, RI 02903, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5233-1221","authenticated-orcid":false,"given":"Beth Burgwyn","family":"Fuchs","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Rhode Island Hospital, Alpert Medical School, and Brown University, Providence, RI 02903, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Johann","sequence":"additional","affiliation":[{"name":"Departamento de Microbiologia, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais, Avenida Presidente Ant\u00f4nio Carlos, 6627, Pampulha, Belo Horizonte\u2014Minas Gerais 31270-901, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,12,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.5216\/rpt.v42i1.23598","article-title":"Perfil de suscetibilidade de Candida tropicalis a antif\u00fangicos sist\u00eamicos","volume":"42","author":"Menezes","year":"2013","journal-title":"Rev. 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