{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:04:18Z","timestamp":1792803858050,"version":"4.5.0"},"reference-count":39,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2019,3,14]],"date-time":"2019-03-14T00:00:00Z","timestamp":1552521600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>Mucormycosis is an emerging life-threatening fungal infection caused by Mucorales. This infection occurs mainly in immunocompromised patients, especially with hematological malignancy, transplantation, or diabetes mellitus. Rhino-orbito-cerebral and pulmonary mucormycosis are the predominant forms. Interestingly, location is associated with the underlying disease as pulmonary mucormycosis is more frequent in hematological malignancy patients whereas rhino-orbito-cerebral mucormycosis is associated with diabetes. Cutaneous mucormycosis results from direct inoculation, mainly after trauma or surgery. Gastro-intestinal mucormycosis occurs after ingestion of contaminated food or with contaminated device and involves the stomach or colon. Disseminated disease is the most severe form and is associated with profound immunosuppression. Uncommon presentations with endocarditis, osteoarticluar or isolated cerebral infections are also described. Finally, health-care associated mucormycosis is a matter of concern in premature newborns and burn units. Clinical symptoms and CT scan findings are not specific, only the early reversed halo sign is associated with pulmonary mucormycosis. Circulating Mucorales DNA detection is a recent promising diagnostic tool that may lead to improving the diagnosis and prompting therapeutic initiation that should include antifungal treatment, correction of the underlying disease and surgery when feasible.<\/jats:p>","DOI":"10.3390\/jof5010023","type":"journal-article","created":{"date-parts":[[2019,3,15]],"date-time":"2019-03-15T04:12:09Z","timestamp":1552623129000},"page":"23","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":130,"title":["Disease Entities in Mucormycosis"],"prefix":"10.3390","volume":"5","author":[{"given":"Alexandra","family":"Serris","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris Descartes, Centre d\u2019Infectiologie Necker Pasteur, IHU Imagine, H\u00f4pital Necker-Enfants Malades, Assistance Publique-H\u00f4pitaux de Paris (AP-HP), 75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Danion","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Descartes, Centre d\u2019Infectiologie Necker Pasteur, IHU Imagine, H\u00f4pital Necker-Enfants Malades, Assistance Publique-H\u00f4pitaux de Paris (AP-HP), 75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanny","family":"Lanternier","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Descartes, Centre d\u2019Infectiologie Necker Pasteur, IHU Imagine, H\u00f4pital Necker-Enfants Malades, Assistance Publique-H\u00f4pitaux de Paris (AP-HP), 75015 Paris, France"},{"name":"Centre National de R\u00e9f\u00e9rence mycoses invasives et antifongiques, Unit\u00e9 de Mycologie Mol\u00e9culaire, Institut Pasteur, 75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,3,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.3201\/eid1509.090334","article-title":"Increasing incidence of zygomycosis (mucormycosis), France, 1997\u20132006","volume":"15","author":"Bitar","year":"2009","journal-title":"Emerg. 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