{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T16:47:47Z","timestamp":1791650867980,"version":"4.3.4"},"reference-count":48,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2019,3,21]],"date-time":"2019-03-21T00:00:00Z","timestamp":1553126400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>Patients with extensive burns are an important group at risk for cutaneous mucormycosis. This study aimed to perform a systematic review of all reported mucormycosis cases in burn patients from 1990 onward. A Medline search yielded identification of 7 case series, 3 outbreaks, and 25 individual cases reports. The prevalence reached 0.04%\u20130.6%. The median age was 42\u201348 in the case series and outbreaks, except for the studies from military centers (23.5\u201332.5) and in individual reports (29.5). The median total body surface area reached 42.5%\u201365%. Various skin lesions were described, none being pathognomonic: the diagnosis was mainly reached because of extensive necrotic lesions sometimes associated with sepsis. Most patients were treated with systemic amphotericin B or liposomal amphotericin B, and all underwent debridement and\/or amputation. Mortality reached 33%\u2013100% in the case series, 29%\u201362% during outbreaks, and 40% in individual cases. Most patients were diagnosed using histopathology and\/or culture. Mucorales qPCR showed detection of circulating DNA 2\u201324 days before the standard diagnosis. Species included the main clinically relevant mucorales (i.e., Mucor, Rhizopus, Absidia\/Lichtheimia, Rhizomucor) but also more uncommon mucorales such as Saksenaea or Apophysomyces. Contact with soil was reported in most individual cases. Bandages were identified as the source of contamination in two nosocomial outbreaks.<\/jats:p>","DOI":"10.3390\/jof5010025","type":"journal-article","created":{"date-parts":[[2019,3,21]],"date-time":"2019-03-21T12:28:01Z","timestamp":1553171281000},"page":"25","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Mucormycosis in Burn Patients"],"prefix":"10.3390","volume":"5","author":[{"given":"Pauline","family":"Devauchelle","sequence":"first","affiliation":[{"name":"CHU Lille, Centre des Br\u00fbl\u00e9s, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Jeanne","sequence":"additional","affiliation":[{"name":"CHU Lille, Centre des Br\u00fbl\u00e9s, F-59000 Lille, France"},{"name":"Univ. Lille, Inserm, CHU Lille, CIC 1403-Centre d\u2019Investigation Clinique, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Fr\u00e9alle","sequence":"additional","affiliation":[{"name":"CHU Lille, Laboratoire de Parasitologie-Mycologie, F-59000 Lille, France"},{"name":"Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019\u2013UMR8204-CIIL-Center for Infection and Immunity of Lille, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,3,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1056\/NEJM196106222642504","article-title":"Mucormycosis in severely burned patients. Report of two cases with extensive destruction of the face and nasal cavity","volume":"264","author":"Rabin","year":"1961","journal-title":"N. Engl. J. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1086\/432579","article-title":"Epidemiology and outcome of zygomycosis: A review of 929 reported cases","volume":"41","author":"Roden","year":"2005","journal-title":"Clin. Infect. Dis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1097\/BCR.0b013e31816673b1","article-title":"Primary cutaneous zygomycosis in a burns patient: A review","volume":"29","author":"Ledgard","year":"2008","journal-title":"J. Burn Care Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1469-0691.2009.02979.x","article-title":"Cutaneous zygomycosis","volume":"15","author":"Skiada","year":"2009","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.clindermatol.2012.01.010","article-title":"Global epidemiology of cutaneous zygomycosis","volume":"30","author":"Skiada","year":"2012","journal-title":"Clin. Dermatol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.burns.2006.08.040","article-title":"Correlation of culture with histopathology in fungal burn wound colonization and infection","volume":"33","author":"Schofield","year":"2007","journal-title":"Burns"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1097\/01.sla.0000256914.16754.80","article-title":"Fungal wound infection (not colonization) is independently associated with mortality in burn patients","volume":"245","author":"Horvath","year":"2007","journal-title":"Ann. Surg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1016\/j.burns.2014.03.013","article-title":"Mucormycosis attributed mortality: A seven-year review of surgical and medical management","volume":"40","author":"Mitchell","year":"2014","journal-title":"Burns"},{"key":"ref_9","first-page":"280","article-title":"Burn injuries and soft tissue traumas complicated by mucormycosis infection: A report of six cases and review of the literature","volume":"28","author":"Kyriopoulos","year":"2015","journal-title":"Ann. Burns Fire Disasters"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/j.burns.2014.10.024","article-title":"Epidemiology of filamentous fungal infections in burned patients: A French retrospective study","volume":"41","author":"Schaal","year":"2015","journal-title":"Burns"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.burns.2013.11.025","article-title":"Incidence of non-candidal fungal infections in severe burn injury: An Australian perspective","volume":"40","author":"Katz","year":"2014","journal-title":"Burns"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1111\/j.1469-0691.2010.03456.x","article-title":"Zygomycosis in Europe: Analysis of 230 cases accrued by the registry of the European Confederation of Medical Mycology (ECMM) Working Group on Zygomycosis between 2005 and 2007","volume":"17","author":"Skiada","year":"2011","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.jhin.2004.12.011","article-title":"An outbreak of Absidia corymbifera infection associated with bandage contamination in a burns unit","volume":"61","author":"Christiaens","year":"2005","journal-title":"J. Hosp. Infect."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.jhin.2018.02.004","article-title":"Real-time polymerase chain reaction detection of Lichtheimia species in bandages associated with cutaneous mucormycosis in burn patients","volume":"99","author":"Rocchi","year":"2018","journal-title":"J. Hosp. Infect."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e00573-18","DOI":"10.1128\/mBio.00573-18","article-title":"Outbreak of Invasive Wound Mucormycosis in a Burn Unit Due to Multiple Strains of Mucor circinelloides f. circinelloides Resolved by Whole-Genome Sequencing","volume":"9","author":"Criscuolo","year":"2018","journal-title":"MBio"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1093\/cid\/ciw563","article-title":"Detection of circulating Mucorales DNA in critically ill burn patients: Preliminary report of a screening strategy for early diagnosis and treatment","volume":"63","author":"Legrand","year":"2016","journal-title":"Clin. Infect. Dis."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1097\/00004630-199907000-00005","article-title":"Rhinocerebral mucormycosis in patients with burns: Case report and review of the literature","volume":"20","author":"Stern","year":"1999","journal-title":"J. Burn Care Rehabil."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"3707","DOI":"10.1128\/JCM.05095-11","article-title":"Saksenaea erythrospora infection following combat trauma","volume":"49","author":"Hospenthal","year":"2011","journal-title":"J. Clin. Microbiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1001\/jamadermatol.2014.2463","article-title":"Black plaques and white nodules in a burn patient. Fusarium and Mucormycosis","volume":"150","author":"Atty","year":"2014","journal-title":"JAMA Dermatol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e582","DOI":"10.1097\/BCR.0000000000000430","article-title":"Burn Wound Mucormycosis: A Case Study on Poor Wound Healing","volume":"38","author":"Stanistreet","year":"2017","journal-title":"J. Burn Care Res."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Akers, K.S., Rowan, M.P., Niece, K.L., Graybill, J.C., Mende, K., Chung, K.K., and Murray, C.K. (2015). Antifungal wound penetration of amphotericin and voriconazole in combat-related injuries: Case report. BMC Infect. Dis., 15.","DOI":"10.1186\/s12879-015-0918-8"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2814","DOI":"10.1128\/JCM.00671-12","article-title":"Invasive Apophysomyces variabilis infection in a burn patient","volume":"50","author":"Calvano","year":"2012","journal-title":"J. Clin. Microbiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1097\/BCR.0b013e3181a28d2f","article-title":"Mucormycosis of the face","volume":"30","author":"Piazza","year":"2009","journal-title":"J. Burn Care Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1097\/00004630-199309000-00010","article-title":"Arterial occlusion and progressive gangrene caused by mucormycosis in a patient with burns","volume":"14","author":"Kraut","year":"1993","journal-title":"J. Burn Care Rehabil."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1056\/NEJM199711203372105","article-title":"Images in clinical medicine. Mucormycosis of the hand and forearm","volume":"337","author":"Lidor","year":"1997","journal-title":"N. Engl. J. Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1097\/BCR.0b013e3181a28e5f","article-title":"Microvascular transfer of burned tissue for mandibular reconstruction","volume":"30","author":"Antonetti","year":"2009","journal-title":"J. Burn Care Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s11046-018-0281-6","article-title":"Widespread Lichtheimia Infection in a Patient with Extensive Burns: Opportunities for Novel Antifungal Agents","volume":"184","author":"Thielen","year":"2019","journal-title":"Mycopathologia"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1128\/JCM.00410-15","article-title":"Combat-Related Pythium aphanidermatum Invasive Wound Infection: Case Report and Discussion of Utility of Molecular Diagnostics","volume":"53","author":"Farmer","year":"2015","journal-title":"J. Clin. Microbiol."},{"key":"ref_29","first-page":"58","article-title":"Myocutaneous Mucormycosis in a Diabetic Burnt Patient Led to Upper Extremity Amputation; A Case Report","volume":"5","author":"Ayaz","year":"2017","journal-title":"Bull. Emerg. Trauma"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s11046-014-9805-x","article-title":"Primary cutaneous mucormycosis in a patient with burn wounds due to Lichtheimia ramosa","volume":"178","author":"Kaur","year":"2014","journal-title":"Mycopathologia"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"e24","DOI":"10.1097\/BCR.0b013e3182335a39","article-title":"Burn wound mucormycosis: A case report","volume":"33","author":"Li","year":"2012","journal-title":"J. Burn Care Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/S0305-4179(97)00099-5","article-title":"Successful cure of an extensive burn injury complicated with Mucor wound sepsis","volume":"24","author":"Tang","year":"1998","journal-title":"Burns"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"374","DOI":"10.5582\/ddt.2018.01064","article-title":"Two cases of osteoarticular Mucor menace: A diagnostic and management conundrum","volume":"12","author":"Bhatt","year":"2018","journal-title":"Drug Discov. Ther."},{"key":"ref_34","first-page":"249","article-title":"Invasive Fungal Infection with Absidia corymbifera in Immunocompetent Patient with Electrical Scalp Burn","volume":"7","author":"Moon","year":"2018","journal-title":"World J. Plast. Surg."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1097\/BCR.0b013e3181f93912","article-title":"Basilar artery occlusion after multifactor coagulopathy including Rhizopus oryzae infection in burns","volume":"31","author":"Struck","year":"2010","journal-title":"J. Burn Care Res."},{"key":"ref_36","first-page":"83","article-title":"Unsuccessful therapy of combined mycotic infection in a severely burned patient: A case study","volume":"51","author":"Mager","year":"2009","journal-title":"Acta Chir. Plast."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1097\/BCR.0b013e318166da78","article-title":"Absidia corymbifera fungal infection in burns: A case report and review of the literature","volume":"29","author":"Constantinides","year":"2008","journal-title":"J. Burn Care Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1128\/jcm.28.9.2151-2153.1990","article-title":"Burn wound zygomycosis caused by Apophysomyces elegans","volume":"28","author":"Cooter","year":"1990","journal-title":"J. Clin. Microbiol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.burns.2009.03.002","article-title":"Burn wounds infected by contaminated water: Case reports, review of the literature and recommendations for treatment","volume":"36","author":"Ribeiro","year":"2010","journal-title":"Burns"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s11046-006-0061-6","article-title":"Saksenaea vasiformis infections: Case report and literature review","volume":"162","author":"Vega","year":"2006","journal-title":"Mycopathologia"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Howard, P., Cancio, L.C., McManus, A., Goodwin, C., Kim, S., and Pruitt, B. (1999). What\u2019s new in burn-associated infections?. Curr. Surg., 397\u2013405.","DOI":"10.1016\/S0149-7944(99)00166-X"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/S1473-3099(16)00071-2","article-title":"Isavuconazole treatment for mucormycosis: A single-arm open-label trial and case-control analysis","volume":"16","author":"Marty","year":"2016","journal-title":"Lancet Infect. Dis."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/1469-0691.12371","article-title":"ESCMID and ECMM joint clinical guidelines for the diagnosis and management of mucormycosis 2013","volume":"20","author":"Cornely","year":"2014","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1111\/j.1469-0691.2012.03976.x","article-title":"Development of a single tube multiplex real-time PCR to detect the most clinically relevant Mucormycetes species","volume":"19","author":"Buitrago","year":"2013","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"3392","DOI":"10.1128\/JCM.01109-10","article-title":"Rapid detection and identification of mucormycetes from culture and tissue samples by use of high-resolution melt analysis","volume":"48","author":"Hrncirova","year":"2010","journal-title":"J. Clin. Microbiol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"e95","DOI":"10.1093\/cid\/cit094","article-title":"Quantitative polymerase chain reaction detection of circulating DNA in serum for early diagnosis of mucormycosis in immunocompromised patients","volume":"56","author":"Millon","year":"2013","journal-title":"Clin. Infect. Dis."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.cmi.2015.12.006","article-title":"Early diagnosis and monitoring of mucormycosis by detection of circulating DNA in serum: Retrospective analysis of 44 cases collected through the French Surveillance Network of Invasive Fungal Infections (RESSIF)","volume":"22","author":"Millon","year":"2016","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.burns.2016.03.005","article-title":"Aetiology of adult burns treated from 2000 to 2012 in a Swiss University Hospital","volume":"42","author":"Moser","year":"2016","journal-title":"Burns"}],"container-title":["Journal of Fungi"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2309-608X\/5\/1\/25\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T12:39:31Z","timestamp":1760186371000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2309-608X\/5\/1\/25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,21]]},"references-count":48,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,3]]}},"alternative-id":["jof5010025"],"URL":"https:\/\/doi.org\/10.3390\/jof5010025","relation":{},"ISSN":["2309-608X"],"issn-type":[{"value":"2309-608X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,21]]}}}