{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T11:51:52Z","timestamp":1790077912843,"version":"4.0.1"},"reference-count":174,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2019,3,27]],"date-time":"2019-03-27T00:00:00Z","timestamp":1553644800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>Mucormycosis is a rare but often fatal or debilitating infection caused by a diverse group of fungi. Animal models have been crucial in advancing our knowledge of mechanisms influencing the pathogenesis of mucormycoses, and to evaluate therapeutic strategies. This review describes the animal models established for mucormycosis, summarizes how they have been applied to study mucormycoses, and discusses the advantages and limitations of the different model systems.<\/jats:p>","DOI":"10.3390\/jof5020027","type":"journal-article","created":{"date-parts":[[2019,3,29]],"date-time":"2019-03-29T03:38:52Z","timestamp":1553830732000},"page":"27","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Animal Models to Study Mucormycosis"],"prefix":"10.3390","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6033-9984","authenticated-orcid":false,"given":"Ilse D.","family":"Jacobsen","sequence":"first","affiliation":[{"name":"Research Group Microbial Immunology, Leibniz Institute for Natural Product Research and Infection Biology (Hans Kn\u00f6ll Institute), Beutenbergstrasse 11a, 07745 Jena, Germany"},{"name":"Institute of Microbiology, Faculty of Biological Sciences, Friedrich Schiller University Jena, 07743 Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,3,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3767\/003158513X666259","article-title":"The family structure of the Mucorales: A synoptic revision based on comprehensive multigene-genealogies","volume":"30","author":"Hoffmann","year":"2013","journal-title":"Persoonia"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.mycres.2007.03.004","article-title":"A higher-level phylogenetic classification of the Fungi","volume":"111","author":"Hibbett","year":"2007","journal-title":"Mycol. Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1093\/cid\/cir864","article-title":"Taxonomy of fungi causing mucormycosis and entomophthoramycosis (zygomycosis) and nomenclature of the disease: Molecular mycologic perspectives","volume":"54","year":"2012","journal-title":"Clin. Infect. Dis."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"S23","DOI":"10.1093\/cid\/cir866","article-title":"Epidemiology and clinical manifestations of mucormycosis","volume":"54","author":"Petrikkos","year":"2012","journal-title":"Clin. Infect. Dis."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1128\/CMR.00056-10","article-title":"Mucormycosis caused by unusual mucormycetes, non-Rhizopus, -Mucor, and -Lichtheimia species","volume":"24","author":"Gomes","year":"2011","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/1469-0691.12566","article-title":"Mucormycosis\u2014From the pathogens to the disease","volume":"20","author":"Binder","year":"2014","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1086\/432579","article-title":"Epidemiology and outcome of zygomycosis: A review of 929 reported cases","volume":"41","author":"Roden","year":"2005","journal-title":"Clin. Infect. Dis."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1093\/jac\/dkp430","article-title":"Forty-one recent cases of invasive zygomycosis from a global clinical registry","volume":"65","author":"Ruping","year":"2010","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1111\/myc.12149","article-title":"Prospective antifungal therapy (PATH) alliance((R)) : Focus on mucormycosis","volume":"57","author":"Kontoyiannis","year":"2014","journal-title":"Mycoses"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1111\/j.1469-0691.2010.03456.x","article-title":"Zygomycosis in Europe: Analysis of 230 cases accrued by the registry of the European Confederation of Medical Mycology (ECMM) Working Group on Zygomycosis between 2005 and 2007","volume":"17","author":"Skiada","year":"2011","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.ijid.2017.07.002","article-title":"Invasive Fungal Infections Secondary to Traumatic Injury","volume":"62","author":"Kronen","year":"2017","journal-title":"Int. J. Infect. Dis."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e00573-18","DOI":"10.1128\/mBio.00573-18","article-title":"Outbreak of Invasive Wound Mucormycosis in a Burn Unit Due to Multiple Strains of Mucor circinelloides f. circinelloides Resolved by Whole-Genome Sequencing","volume":"9","author":"Criscuolo","year":"2018","journal-title":"mBio"},{"key":"ref_13","first-page":"280","article-title":"Burn injuries and soft tissue traumas complicated by mucormycosis infection: A report of six cases and review of the literature","volume":"28","author":"Kyriopoulos","year":"2015","journal-title":"Ann. Burns Fire Disasters"},{"key":"ref_14","first-page":"147","article-title":"Fungal infections in burns: A comprehensive review","volume":"26","author":"Struck","year":"2013","journal-title":"Ann. Burns Fire Disasters"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1097\/MD.0000000000000221","article-title":"Posttraumatic mucormycosis: A nationwide study in France and review of the literature","volume":"93","author":"Lelievre","year":"2014","journal-title":"Medicine (Baltimore)"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e434","DOI":"10.1016\/j.bjps.2008.04.040","article-title":"Cutaneous mucormycosis: Report of five cases and review of the literature","volume":"62","year":"2009","journal-title":"J. Plast. Reconstr. Aesthet. Surg."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.clindermatol.2012.01.010","article-title":"Global epidemiology of cutaneous zygomycosis","volume":"30","author":"Skiada","year":"2012","journal-title":"Clin. Dermatol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1111\/myc.12798","article-title":"Gastrointestinal mucormycosis in apparently immunocompetent hosts-A review","volume":"61","author":"Kaur","year":"2018","journal-title":"Mycoses"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/S0140-6736(96)05059-3","article-title":"Nosocomial infection with Rhizopus microsporus in preterm infants: Association with wooden tongue depressors","volume":"348","author":"Mitchell","year":"1996","journal-title":"Lancet"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Pana, Z.D., Seidel, D., Skiada, A., Groll, A.H., Petrikkos, G., Cornely, O.A., and Roilides, E. (2016). Invasive mucormycosis in children: An epidemiologic study in European and non-European countries based on two registries. BMC Infect. Dis., 16.","DOI":"10.1186\/s12879-016-2005-1"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1093\/mmy\/myx017","article-title":"Diabetes mellitus as the major risk factor for mucormycosis in Mexico: Epidemiology, diagnosis, and outcomes of reported cases","volume":"56","author":"Walsh","year":"2018","journal-title":"Med. Mycol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1128\/CMR.18.3.556-569.2005","article-title":"Novel perspectives on mucormycosis: Pathophysiology, presentation, and management","volume":"18","author":"Spellberg","year":"2005","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.cmi.2018.07.011","article-title":"The epidemiology and clinical manifestations of mucormycosis: A systematic review and meta-analysis of case reports","volume":"25","author":"Jeong","year":"2019","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1093\/mmy\/myx104","article-title":"Fungal infections in animals: A patchwork of different situations","volume":"56","author":"Seyedmousavi","year":"2018","journal-title":"Med. Mycol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/myc.12239","article-title":"Mucormycoses caused by Lichtheimia species","volume":"57","author":"Schwartze","year":"2014","journal-title":"Mycoses"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1023\/A:1011900630987","article-title":"Animal models of zygomycosis\u2014Absidia, Rhizopus, Rhizomucor, and Cunninghamella","volume":"152","author":"Kamei","year":"2001","journal-title":"Mycopathologia"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Buskirk, A.D., Green, B.J., Lemons, A.R., Nayak, A.P., Goldsmith, W.T., Kashon, M.L., Anderson, S.E., Hettick, J.M., Templeton, S.P., and Germolec, D.R. (2014). A murine inhalation model to characterize pulmonary exposure to dry Aspergillus fumigatus conidia. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0109855"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1128\/AAC.48.5.1908-1911.2004","article-title":"Novel inhalational murine model of invasive pulmonary aspergillosis","volume":"48","author":"Sheppard","year":"2004","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1080\/13693780410001712034","article-title":"Value of an inhalational model of invasive aspergillosis","volume":"42","author":"Steinbach","year":"2004","journal-title":"Med. Mycol."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Cai, Y., and Kimura, S. (2013). Noninvasive intratracheal intubation to study the pathology and physiology of mouse lung. J. Vis. Exp., e50601.","DOI":"10.3791\/50601-v"},{"key":"ref_31","first-page":"e1504","article-title":"Non-invasive Intratracheal Instillation in Mice","volume":"5","author":"Looney","year":"2015","journal-title":"Bio Protoc"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Madenspacher, J.H., and Fessler, M.B. (2016). A Non-invasive and Technically Non-intensive Method for Induction and Phenotyping of Experimental Bacterial Pneumonia in Mice. J. Vis. Exp.","DOI":"10.3791\/54508"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.ajpath.2014.11.012","article-title":"Pathogenesis of infection with 2009 pandemic H1N1 influenza virus in isogenic guinea pigs after intranasal or intratracheal inoculation","volume":"185","author":"Wiersma","year":"2015","journal-title":"Am. J. Pathol."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Egger, C., Cannet, C., Gerard, C., Jarman, E., Jarai, G., Feige, A., Suply, T., Micard, A., Dunbar, A., and Tigani, B. (2013). Administration of bleomycin via the oropharyngeal aspiration route leads to sustained lung fibrosis in mice and rats as quantified by UTE-MRI and histology. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0063432"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1080\/21505594.2017.1360460","article-title":"Ketoacidosis alone does not predispose to mucormycosis by Lichtheimia in a murine pulmonary infection model","volume":"8","author":"Schulze","year":"2017","journal-title":"Virulence"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2649","DOI":"10.1172\/JCI32338","article-title":"The iron chelator deferasirox protects mice from mucormycosis through iron starvation","volume":"117","author":"Ibrahim","year":"2007","journal-title":"J. Clin. Investig."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.5858\/arpa.2013-0592-OA","article-title":"Quantitative multiplexed detection of common pulmonary fungal pathogens by labeled primer polymerase chain reaction","volume":"138","author":"Gu","year":"2014","journal-title":"Arch. Pathol. Lab. Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"3333","DOI":"10.1038\/s41467-018-05820-2","article-title":"Iron restriction inside macrophages regulates pulmonary host defense against Rhizopus species","volume":"9","author":"Andrianaki","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"e01384-18","DOI":"10.1128\/mBio.01384-18","article-title":"Inhibition of EGFR Signaling Protects from Mucormycosis","volume":"9","author":"Watkins","year":"2018","journal-title":"mBio"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"e00746-18","DOI":"10.1128\/JCM.00746-18","article-title":"PCR-Based Approach Targeting Mucorales-Specific Gene Family for Diagnosis of Mucormycosis","volume":"56","author":"Baldin","year":"2018","journal-title":"J. Clin. Microbiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"e00390-17","DOI":"10.1128\/AAC.00390-17","article-title":"Prophylactic Treatment with VT-1161 Protects Immunosuppressed Mice from Rhizopus arrhizus var. arrhizus Infection","volume":"61","author":"Gebremariam","year":"2017","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"e02589-16","DOI":"10.1128\/AAC.02589-16","article-title":"Prophylaxis with Isavuconazole or Posaconazole Protects Immunosuppressed Mice from Pulmonary Mucormycosis","volume":"61","author":"Gebremariam","year":"2017","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1093\/jac\/dkw433","article-title":"Monotherapy or combination therapy of isavuconazole and micafungin for treating murine mucormycosis","volume":"72","author":"Gebremariam","year":"2017","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.1172\/JCI82744","article-title":"Bicarbonate correction of ketoacidosis alters host-pathogen interactions and alleviates mucormycosis","volume":"126","author":"Gebremariam","year":"2016","journal-title":"J. Clin. Investig."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"7815","DOI":"10.1128\/AAC.01437-15","article-title":"VT-1161 Protects Immunosuppressed Mice from Rhizopus arrhizus var. arrhizus Infection","volume":"59","author":"Gebremariam","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1016\/j.vaccine.2014.04.086","article-title":"Heat-killed yeast protects diabetic ketoacidotic-steroid treated mice from pulmonary mucormycosis","volume":"32","author":"Luo","year":"2014","journal-title":"Vaccine"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2450","DOI":"10.1128\/AAC.02301-13","article-title":"Isavuconazole therapy protects immunosuppressed mice from mucormycosis","volume":"58","author":"Luo","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1172\/JCI71349","article-title":"CotH3 mediates fungal invasion of host cells during mucormycosis","volume":"124","author":"Gebremariam","year":"2014","journal-title":"J. Clin. Investig."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"3340","DOI":"10.1128\/AAC.00313-13","article-title":"Efficacy of liposomal amphotericin B and posaconazole in intratracheal models of murine mucormycosis","volume":"57","author":"Luo","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1093\/mmy\/myw146","article-title":"Identification of a Novel Rhizopus-specific Antigen by Screening with a Signal Sequence Trap and Evaluation as a Possible Diagnostic Marker of Mucormycosis","volume":"55","author":"Sato","year":"2017","journal-title":"Med. Mycol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.jiac.2013.09.002","article-title":"Efficacy of aerosolized liposomal amphotericin B against murine invasive pulmonary mucormycosis","volume":"20","author":"Mihara","year":"2014","journal-title":"J. Infect. Chemother"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1093\/infdis\/jiw090","article-title":"Statin Concentrations Below the Minimum Inhibitory Concentration Attenuate the Virulence of Rhizopus oryzae","volume":"214","author":"Bellanger","year":"2016","journal-title":"J. Infect. Dis."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1172\/JCI42164","article-title":"The endothelial cell receptor GRP78 is required for mucormycosis pathogenesis in diabetic mice","volume":"120","author":"Liu","year":"2010","journal-title":"J. Clin. Investig."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"3584","DOI":"10.1128\/AAC.01812-10","article-title":"Efficacy of caspofungin in neutropenic and corticosteroid-immunosuppressed murine models of invasive pulmonary mucormycosis","volume":"55","author":"Lewis","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1128\/AAC.01222-09","article-title":"Comparative pharmacodynamics of amphotericin B lipid complex and liposomal amphotericin B in a murine model of pulmonary mucormycosis","volume":"54","author":"Lewis","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"6767","DOI":"10.1128\/AAC.03569-14","article-title":"Comparative pharmacodynamics of posaconazole in neutropenic murine models of invasive pulmonary aspergillosis and mucormycosis","volume":"58","author":"Lewis","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1128\/AAC.44.7.2004-2006.2000","article-title":"Combination antifungal therapy in treatment of murine pulmonary mucormycosis: Roles of quinolones and azoles","volume":"44","author":"Sugar","year":"2000","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"348","DOI":"10.4161\/viru.2.4.17074","article-title":"Voriconazole pre-exposure selects for breakthrough mucormycosis in a mixed model of Aspergillus fumigatus-Rhizopus oryzae pulmonary infection","volume":"2","author":"Lewis","year":"2011","journal-title":"Virulence"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1128\/AAC.00956-09","article-title":"Antifungal activity of colistin against mucorales species in vitro and in a murine model of Rhizopus oryzae pulmonary infection","volume":"54","author":"Lewis","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1086\/597615","article-title":"Increased virulence of Zygomycetes organisms following exposure to voriconazole: A study involving fly and murine models of zygomycosis","volume":"199","author":"Lamaris","year":"2009","journal-title":"J. Infect. Dis."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1080\/21505594.2018.1435249","article-title":"Understanding Mucor circinelloides pathogenesis by comparative genomics and phenotypical studies","volume":"9","author":"Sanchis","year":"2018","journal-title":"Virulence"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"72","DOI":"10.3109\/13693786.2012.690107","article-title":"Increased virulence of Cunninghamella bertholletiae in experimental pulmonary mucormycosis: Correlation with circulating molecular biomarkers, sporangiospore germination and hyphal metabolism","volume":"51","author":"Petraitis","year":"2013","journal-title":"Med. Mycol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"3690","DOI":"10.1128\/JCM.00917-08","article-title":"Detection of a molecular biomarker for zygomycetes by quantitative PCR assays of plasma, bronchoalveolar lavage, and lung tissue in a rabbit model of experimental pulmonary zygomycosis","volume":"46","author":"Kasai","year":"2008","journal-title":"J. Clin. Microbiol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1080\/00362178185380421","article-title":"Experimental cerebral zygomycosis in alloxan-diabetic rabbits: Variation in virulence among zygomycetes","volume":"19","author":"Reinhardt","year":"1981","journal-title":"Sabouraudia"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1023\/A:1006937708546","article-title":"Experimental zygomycosis in rabbits: Clinicopathological studies","volume":"144","author":"Sondhi","year":"1998\u20131999","journal-title":"Mycopathologia"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1023\/A:1006464514852","article-title":"Effect of immunosuppression on the clinicopathological changes in experimental zygomycosis in rabbits","volume":"24","author":"Sondhi","year":"2000","journal-title":"Vet. Res. Commun."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1111\/j.1439-0507.1988.tb04410.x","article-title":"Experimental zygomycosis due to Rhizopus spp. infection by various routes in guinea-pigs, rats and mice","volume":"31","author":"Fransen","year":"1988","journal-title":"Mycoses"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0021-9975(73)90026-1","article-title":"Localization and fate of Absidia ramosa spores after intravenous inoculation of mice","volume":"83","author":"Smith","year":"1973","journal-title":"J. Comp. Pathol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1080\/00362177885380181","article-title":"Observations on the localization of Absidia corymbifera in vivo","volume":"16","author":"Corbel","year":"1978","journal-title":"Sabouraudia"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1099\/00222615-8-4-551","article-title":"Factors determining the susceptibility of mice to experimental phycomycosis","volume":"8","author":"Corbel","year":"1975","journal-title":"J. Med. Microbiol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1128\/AAC.01577-10","article-title":"Combination therapy of murine mucormycosis or aspergillosis with iron chelation, polyenes, and echinocandins","volume":"55","author":"Ibrahim","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"e01390-14","DOI":"10.1128\/mBio.01390-14","article-title":"Analysis of a food-borne fungal pathogen outbreak: Virulence and genome of a Mucor circinelloides isolate from yogurt","volume":"5","author":"Lee","year":"2014","journal-title":"mBio"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"e02765-18","DOI":"10.1128\/mBio.02765-18","article-title":"Mucor circinelloides Thrives inside the Phagosome through an Atf-Mediated Germination Pathway","volume":"10","author":"Murcia","year":"2019","journal-title":"mBio"},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Liu, M., Lin, L., Gebremariam, T., Luo, G., Skory, C.D., French, S.W., Chou, T.F., Edwards, J.E., and Ibrahim, A.S. (2015). Fob1 and Fob2 Proteins Are Virulence Determinants of Rhizopus oryzae via Facilitating Iron Uptake from Ferrioxamine. PLoS Pathog., 11.","DOI":"10.1371\/journal.ppat.1004842"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1128\/AAC.01463-09","article-title":"Correlation between in vitro activity of posaconazole and in vivo efficacy against Rhizopus oryzae infection in mice","volume":"54","author":"Rodriguez","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1111\/j.1365-2958.2010.07234.x","article-title":"The high affinity iron permease is a key virulence factor required for Rhizopus oryzae pathogenesis","volume":"77","author":"Ibrahim","year":"2010","journal-title":"Mol. Microbiol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1086\/591461","article-title":"Bacterial endosymbiosis is widely present among zygomycetes but does not contribute to the pathogenesis of mucormycosis","volume":"198","author":"Ibrahim","year":"2008","journal-title":"J. Infect. Dis."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1288\/00005537-199206000-00011","article-title":"Intracranial complications of mucormycosis: An experimental model and clinical review","volume":"102","author":"Anand","year":"1992","journal-title":"Laryngoscope"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1128\/iai.44.1.194-195.1984","article-title":"Cerebral mucormycosis in diabetic mice after intrasinus challenge","volume":"44","author":"Waldorf","year":"1984","journal-title":"Infect. Immun."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1084\/jem.108.1.171","article-title":"Activation of quiescent mucormycotic granulomata in rabbits by induction of acute alloxan diabetes","volume":"108","author":"Sheldon","year":"1958","journal-title":"J. Exp. Med."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1084\/jem.110.6.845","article-title":"The development of the acute inflammatory response to experimental cutaneous mucormycosis in normal and diabetic rabbits","volume":"110","author":"Sheldon","year":"1959","journal-title":"J. Exp. Med."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1084\/jem.112.6.1069","article-title":"Tissue mast cells and acute inflammation in experimental cutaneous mucromycosis of normal, 48\/80- treated, and diabetic rats","volume":"112","author":"Sheldon","year":"1960","journal-title":"J. Exp. Med."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1093\/infdis\/jis767","article-title":"Tacrolimus enhances the potency of posaconazole against Rhizopus oryzae in vitro and in an experimental model of mucormycosis","volume":"207","author":"Lewis","year":"2013","journal-title":"J. Infect. Dis."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Bao, W., Jin, L., Fu, H.J., Shen, Y.N., Lu, G.X., Mei, H., Cao, X.Z., Wang, H.S., and Liu, W.D. (2013). Interleukin-22 mediates early host defense against Rhizomucor pusilluscan pathogens. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0065065"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/j.1439-0507.1992.tb00872.x","article-title":"Murine subcutaneous granulomatous zygomycosis induced by Absidia corymbifera","volume":"35","author":"Jensen","year":"1992","journal-title":"Mycoses"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1007\/s00277-017-3098-3","article-title":"Diagnosis and empirical treatment of fever of unknown origin (FUO) in adult neutropenic patients: Guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO)","volume":"96","author":"Heinz","year":"2017","journal-title":"Ann. Hematol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1086\/516455","article-title":"Assessment of a mouse model of neutropenia and the effect of an anti-candidiasis monoclonal antibody in these animals","volume":"175","author":"Han","year":"1997","journal-title":"J. Infect. Dis."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1128\/IAI.73.1.114-125.2005","article-title":"The pathogenesis of fatal outcome in murine pulmonary aspergillosis depends on the neutrophil depletion strategy","volume":"73","author":"Mednick","year":"2005","journal-title":"Infect. Immun."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"3034","DOI":"10.1128\/IAI.71.6.3034-3042.2003","article-title":"Killing of Aspergillus fumigatus by alveolar macrophages is mediated by reactive oxidant intermediates","volume":"71","author":"Philippe","year":"2003","journal-title":"Infect. Immun."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1128\/IAI.73.1.494-503.2005","article-title":"Differences in patterns of infection and inflammation for corticosteroid treatment and chemotherapy in experimental invasive pulmonary aspergillosis","volume":"73","author":"Balloy","year":"2005","journal-title":"Infect. Immun."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"S97","DOI":"10.1080\/13693780802056012","article-title":"What do we know about the role of gliotoxin in the pathobiology of Aspergillus fumigatus?","volume":"47","author":"Sugui","year":"2009","journal-title":"Med. Mycol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"S61","DOI":"10.1093\/cid\/cir869","article-title":"Host defenses against zygomycetes","volume":"54","author":"Roilides","year":"2012","journal-title":"Clin. Infect. Dis."},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Trieu, T.A., Navarro-Mendoza, M.I., Perez-Arques, C., Sanchis, M., Capilla, J., Navarro-Rodriguez, P., Lopez-Fernandez, L., Torres-Martinez, S., Garre, V., and Ruiz-Vazquez, R.M. (2017). RNAi-Based Functional Genomics Identifies New Virulence Determinants in Mucormycosis. PLoS Pathog., 13.","DOI":"10.1371\/journal.ppat.1006150"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1128\/AAC.00969-06","article-title":"Posaconazole prophylaxis in experimental systemic zygomycosis","volume":"51","author":"Barchiesi","year":"2007","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"e486","DOI":"10.1111\/j.1439-0507.2010.01958.x","article-title":"Antifungal activity of posaconazole and granulocyte colony-stimulating factor in the treatment of disseminated zygomycosis (mucormycosis) in a neutropaenic murine model","volume":"54","author":"Saoulidis","year":"2011","journal-title":"Mycoses"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"2246","DOI":"10.1128\/AAC.05956-11","article-title":"In vitro and in vivo activities of posaconazole and amphotericin B in a murine invasive infection by Mucor circinelloides: Poor efficacy of posaconazole","volume":"56","author":"Salas","year":"2012","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1007\/s10156-010-0071-7","article-title":"Comparative study of the efficacy of liposomal amphotericin B and amphotericin B deoxycholate against six species of Zygomycetes in a murine lethal infection model","volume":"16","author":"Takemoto","year":"2010","journal-title":"J. Infect. Chemother"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"4550","DOI":"10.1128\/AAC.00786-10","article-title":"In vitro and in vivo antifungal susceptibilities of the Mucoralean fungus Cunninghamella","volume":"54","author":"Pastor","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"7660","DOI":"10.1038\/s41598-018-26051-x","article-title":"Components of a new gene family of ferroxidases involved in virulence are functionally specialized in fungal dimorphism","volume":"8","author":"Murcia","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1080\/00362178285380321","article-title":"Murine model of pulmonary mucormycosis in cortisone-treated mice","volume":"20","author":"Waldorf","year":"1982","journal-title":"Sabouraudia"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1128\/AAC.01458-07","article-title":"Combination echinocandin-polyene treatment of murine mucormycosis","volume":"52","author":"Ibrahim","year":"2008","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1093\/jac\/dkl350","article-title":"Deferiprone iron chelation as a novel therapy for experimental mucormycosis","volume":"58","author":"Ibrahim","year":"2006","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1128\/AAC.49.2.830-832.2005","article-title":"Combination therapy with amphotericin B lipid complex and caspofungin acetate of disseminated zygomycosis in diabetic ketoacidotic mice","volume":"49","author":"Spellberg","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1128\/AAC.49.2.721-727.2005","article-title":"Caspofungin inhibits Rhizopus oryzae 1,3-beta-D-glucan synthase, lowers burden in brain measured by quantitative PCR, and improves survival at a low but not a high dose during murine disseminated zygomycosis","volume":"49","author":"Ibrahim","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"3343","DOI":"10.1128\/AAC.47.10.3343-3344.2003","article-title":"Liposomal amphotericin B, and not amphotericin B deoxycholate, improves survival of diabetic mice infected with Rhizopus oryzae","volume":"47","author":"Ibrahim","year":"2003","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1172\/JCI111395","article-title":"Specific susceptibility to mucormycosis in murine diabetes and bronchoalveolar macrophage defense against Rhizopus","volume":"74","author":"Waldorf","year":"1984","journal-title":"J. Clin. Investig."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1007\/s00294-017-0798-0","article-title":"Control of morphology and virulence by ADP-ribosylation factors (ARF) in Mucor circinelloides","volume":"64","year":"2018","journal-title":"Curr. Genet."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Li, C.H., Cervantes, M., Springer, D.J., Boekhout, T., Ruiz-Vazquez, R.M., Torres-Martinez, S.R., Heitman, J., and Lee, S.C. (2011). Sporangiospore size dimorphism is linked to virulence of Mucor circinelloides. PLoS Pathog., 7.","DOI":"10.1371\/journal.ppat.1002086"},{"key":"ref_109","first-page":"9051426","article-title":"Experimental Diabetes Mellitus in Different Animal Models","volume":"2016","author":"Kupai","year":"2016","journal-title":"J. Diabetes Res."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bcp.2015.08.108","article-title":"Animal models for diabetes: Understanding the pathogenesis and finding new treatments","volume":"99","author":"King","year":"2016","journal-title":"Biochem. Pharmacol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.cbi.2015.11.032","article-title":"Challenges and issues with streptozotocin-induced diabetes\u2014A clinically relevant animal model to understand the diabetes pathogenesis and evaluate therapeutics","volume":"244","author":"Goyal","year":"2016","journal-title":"Chem. Biol. Interact."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/myc.12232","article-title":"Host-iron assimilation: Pathogenesis and novel therapies of mucormycosis","volume":"57","author":"Ibrahim","year":"2014","journal-title":"Mycoses"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1093\/jac\/48.4.583","article-title":"Treatment of Absidia corymbifera infection in mice with amphotericin B and itraconazole","volume":"48","author":"Mosquera","year":"2001","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1128\/JCM.44.2.340-349.2006","article-title":"Molecular identification of zygomycetes from culture and experimentally infected tissues","volume":"44","author":"Schwarz","year":"2006","journal-title":"J. Clin. Microbiol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1016\/j.drudis.2014.06.006","article-title":"Animal models of invasive aspergillosis for drug discovery","volume":"19","author":"Paulussen","year":"2014","journal-title":"Drug Dis. Today"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"841","DOI":"10.3389\/fmicb.2017.00841","article-title":"Rodent Models of Invasive Aspergillosis due to Aspergillus fumigatus: Still a Long Path toward Standardization","volume":"8","author":"Desoubeaux","year":"2017","journal-title":"Front. Microbiol."},{"key":"ref_117","first-page":"S1","article-title":"The 3Rs in research: A contemporary approach to replacement, reduction and refinement","volume":"120","year":"2018","journal-title":"Br. J. Nutr."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"3241","DOI":"10.1007\/s00018-014-1612-5","article-title":"Animal models in burn research","volume":"71","author":"Abdullahi","year":"2014","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1097\/00005373-198402000-00003","article-title":"Relative roles of burn injury, wound colonization, and wound infection in induction of alterations of complement function in a guinea pig model of burn injury","volume":"24","author":"Bjornson","year":"1984","journal-title":"J. Trauma"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1128\/iai.49.3.780-784.1985","article-title":"Experimental candidiasis after thermal injury","volume":"49","author":"Fader","year":"1985","journal-title":"Infect. Immun."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1111\/j.1751-1097.2011.00886.x","article-title":"Ultraviolet-C light for treatment of Candida albicans burn infection in mice","volume":"87","author":"Dai","year":"2011","journal-title":"Photochem. Photobiol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1182\/blood-2011-03-316430","article-title":"How I treat mucormycosis","volume":"118","author":"Kontoyiannis","year":"2011","journal-title":"Blood"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1093\/infdis\/150.5.752","article-title":"In vivo bronchoalveolar macrophage defense against Rhizopus oryzae and Aspergillus fumigatus","volume":"150","author":"Waldorf","year":"1984","journal-title":"J. Infect. Dis."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"4489","DOI":"10.1128\/iai.63.11.4489-4494.1995","article-title":"Human and rat macrophages mediate fungistatic activity against Rhizopus species differently: In vitro and ex vivo studies","volume":"63","author":"Jorens","year":"1995","journal-title":"Infect. Immun."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1093\/infdis\/154.3.483","article-title":"In vitro killing of spores and hyphae of Aspergillus fumigatus and Rhizopus oryzae by rabbit neutrophil cationic peptides and bronchoalveolar macrophages","volume":"154","author":"Levitz","year":"1986","journal-title":"J. Infect. Dis."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1084\/jem.106.4.501","article-title":"Leukopenia with granulocytopenia in experimental mucormycosis (Rhizopus oryzae infection)","volume":"106","author":"Bauer","year":"1957","journal-title":"J. Exp. Med."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"e02010-17","DOI":"10.1128\/mBio.02010-17","article-title":"Robust Phagocyte Recruitment Controls the Opportunistic Fungal Pathogen Mucor circinelloides in Innate Granulomas In Vivo","volume":"9","author":"Inglesfield","year":"2018","journal-title":"mBio"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.jinf.2018.06.016","article-title":"Reactivation of dormant\/latent fungal infection","volume":"77","author":"Brunet","year":"2018","journal-title":"J. Infect."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/978-1-61779-539-8_34","article-title":"Embryonated chicken eggs as alternative infection model for pathogenic fungi","volume":"845","author":"Jacobsen","year":"2012","journal-title":"Methods Mol. Biol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"2995","DOI":"10.1128\/IAI.00268-10","article-title":"Embryonated eggs as an alternative infection model to investigate Aspergillus fumigatus virulence","volume":"78","author":"Jacobsen","year":"2010","journal-title":"Infect. Immun."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1080\/21505594.2015.1029219","article-title":"Adaptation to thermotolerance in Rhizopus coincides with virulence as revealed by avian and invertebrate infection models, phylogeny, physiological and metabolic flexibility","volume":"6","author":"Kaerger","year":"2015","journal-title":"Virulence"},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Schwartze, V.U., Hoffmann, K., Nyilasi, I., Papp, T., Vagvolgyi, C., de Hoog, S., Voigt, K., and Jacobsen, I.D. (2012). Lichtheimia species exhibit differences in virulence potential. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0040908"},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Rosowski, E.E., Knox, B.P., Archambault, L.S., Huttenlocher, A., Keller, N.P., Wheeler, R.T., and Davis, J.M. (2018). The Zebrafish as a Model Host for Invasive Fungal Infections. J. Fungi (Basel), 4.","DOI":"10.3390\/jof4040136"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.dci.2014.01.020","article-title":"Utilization of zebrafish for intravital study of eukaryotic pathogen-host interactions","volume":"46","author":"Gratacap","year":"2014","journal-title":"Dev. Comp. Immunol."},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Brothers, K.M., and Wheeler, R.T. (2012). Non-invasive imaging of disseminated candidiasis in zebrafish larvae. J. Vis. Exp.","DOI":"10.3791\/4051"},{"key":"ref_136","first-page":"1375","article-title":"A zebrafish larval model reveals early tissue-specific innate immune responses to Mucor circinelloides","volume":"8","author":"Voelz","year":"2015","journal-title":"Dis. Model. Mech."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"12802","DOI":"10.1038\/s41598-018-30754-6","article-title":"An Adult Zebrafish Model Reveals that Mucormycosis Induces Apoptosis of Infected Macrophages","volume":"8","author":"Nicolas","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Singulani, J.L., Scorzoni, L., de Oliveira, H.C., Marcos, C.M., Assato, P.A., Fusco-Almeida, A.M., and Mendes-Giannini, M.J.S. (2018). Applications of Invertebrate Animal Models to Dimorphic Fungal Infections. J. Fungi, 4.","DOI":"10.3390\/jof4040118"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1016\/j.bbadis.2013.03.008","article-title":"Invertebrate models of fungal infection","volume":"1832","author":"Arvanitis","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.funbio.2015.06.002","article-title":"Galleria mellonella: An invertebrate model to study pathogenicity in correctly defined fungal species","volume":"120","author":"Binder","year":"2016","journal-title":"Fungal Biol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/978-1-61779-539-8_33","article-title":"Galleria mellonella as a model for fungal pathogenicity testing","volume":"845","author":"Fallon","year":"2012","journal-title":"Methods Mol. Biol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.femsre.2003.09.002","article-title":"Exploiting the potential of insects for in vivo pathogenicity testing of microbial pathogens","volume":"28","author":"Kavanagh","year":"2004","journal-title":"FEMS Microbiol. Rev."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"475","DOI":"10.4161\/viru.1.6.12985","article-title":"Methods for using Galleria mellonella as a model host to study fungal pathogenesis","volume":"1","author":"Fuchs","year":"2010","journal-title":"Virulence"},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Champion, O.L., Titball, R.W., and Bates, S. (2018). Standardization of G. mellonella Larvae to Provide Reliable and Reproducible Results in the Study of Fungal Pathogens. J. Fungi (Basel), 4.","DOI":"10.3390\/jof4030108"},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Pereira, T.C., de Barros, P.P., Fugisaki, L.R.O., Rossoni, R.D., Ribeiro, F.C., de Menezes, R.T., Junqueira, J.C., and Scorzoni, L. (2018). Recent Advances in the Use of Galleria mellonella Model to Study Immune Responses against Human Pathogens. J. Fungi (Basel), 4.","DOI":"10.3390\/jof4040128"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1016\/S0965-1748(02)00092-9","article-title":"Insect hemocytes and their role in immunity","volume":"32","author":"Lavine","year":"2002","journal-title":"Insect Biochem. Mol. Biol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"597","DOI":"10.4161\/viru.25906","article-title":"An analysis of the structural and functional similarities of insect hemocytes and mammalian phagocytes","volume":"4","author":"Browne","year":"2013","journal-title":"Virulence"},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"Trevijano-Contador, N., and Zaragoza, O. (2018). Immune Response of Galleria mellonella against Human Fungal Pathogens. J. Fungi (Basel), 5.","DOI":"10.3390\/jof5010003"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1093\/mmy\/myy042","article-title":"Galleria mellonella as a model system to study virulence potential of mucormycetes and evaluation of antifungal treatment","volume":"57","author":"Maurer","year":"2018","journal-title":"Med. Mycol."},{"key":"ref_150","doi-asserted-by":"crossref","unstructured":"Macedo, D., Leonardelli, F., Dudiuk, C., Vitale, R.G., Del Valle, E., Giusiano, G., Gamarra, S., and Garcia-Effron, G. (2019). In Vitro and In Vivo Evaluation of Voriconazole-Containing Antifungal Combinations against Mucorales Using a Galleria mellonella Model of Mucormycosis. J. Fungi (Basel), 5.","DOI":"10.3390\/jof5010005"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1128\/EC.05284-11","article-title":"Rapamycin exerts antifungal activity in vitro and in vivo against Mucor circinelloides via FKBP12-dependent inhibition of Tor","volume":"11","author":"Bastidas","year":"2012","journal-title":"Eukaryotic cell"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1038\/nri2194","article-title":"The Drosophila systemic immune response: Sensing and signalling during bacterial and fungal infections","volume":"7","author":"Ferrandon","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/S0092-8674(00)80172-5","article-title":"The dorsoventral regulatory gene cassette spatzle\/Toll\/cactus controls the potent antifungal response in Drosophila adults","volume":"86","author":"Lemaitre","year":"1996","journal-title":"Cell"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/978-1-61779-539-8_32","article-title":"Drosophila melanogaster as a model organism for invasive aspergillosis","volume":"845","author":"Lionakis","year":"2012","journal-title":"Methods Mol. Biol."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"253","DOI":"10.4161\/viru.27524","article-title":"Human pathogenic bacteria, fungi, and viruses in Drosophila: Disease modeling, lessons, and shortcomings","volume":"5","author":"Panayidou","year":"2014","journal-title":"Virulence"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/S1473-3099(06)70686-7","article-title":"Role of mini-host models in the study of medically important fungi","volume":"7","author":"Chamilos","year":"2007","journal-title":"Lancet Infect. Dis."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1086\/500950","article-title":"Drosophila melanogaster as a facile model for large-scale studies of virulence mechanisms and antifungal drug efficacy in Candida species","volume":"193","author":"Chamilos","year":"2006","journal-title":"J. Infect. Dis."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.tim.2004.03.007","article-title":"Drosophila: A polyvalent model to decipher host-pathogen interactions","volume":"12","author":"Vodovar","year":"2004","journal-title":"Trends Microbiol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"521","DOI":"10.4161\/viru.2.6.18520","article-title":"Drosophila and Galleria insect model hosts: New tools for the study of fungal virulence, pharmacology and immunology","volume":"2","author":"Lionakis","year":"2011","journal-title":"Virulence"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"9367","DOI":"10.1073\/pnas.0709578105","article-title":"Drosophila melanogaster as a model host to dissect the immunopathogenesis of zygomycosis","volume":"105","author":"Chamilos","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"4569","DOI":"10.1128\/AAC.00994-09","article-title":"Culture medium composition affects the lethality of Cunninghamella bertholletiae in a fly model of mucormycosis","volume":"53","author":"Pongas","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_162","doi-asserted-by":"crossref","unstructured":"Shirazi, F., Farmakiotis, D., Yan, Y., Albert, N., Do, K.A., and Kontoyiannis, D.P. (2014). Diet modification and metformin have a beneficial effect in a fly model of obesity and mucormycosis. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0108635"},{"key":"ref_163","doi-asserted-by":"crossref","unstructured":"Unckless, R.L., Rottschaefer, S.M., and Lazzaro, B.P. (2015). The complex contributions of genetics and nutrition to immunity in Drosophila melanogaster. PLoS Genetics, 11.","DOI":"10.1371\/journal.pgen.1005030"},{"key":"ref_164","doi-asserted-by":"crossref","unstructured":"Shelburne, S.A., Ajami, N.J., Chibucos, M.C., Beird, H.C., Tarrand, J., Galloway-Pena, J., Albert, N., Chemaly, R.F., Ghantoji, S.S., and Marsh, L. (2015). Implementation of a Pan-Genomic Approach to Investigate Holobiont-Infecting Microbe Interaction: A Case Report of a Leukemic Patient with Invasive Mucormycosis. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0139851"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"7830","DOI":"10.1128\/AAC.01583-15","article-title":"Effect of Preexposure to Triazoles on Susceptibility and Virulence of Rhizopus oryzae","volume":"59","author":"Bellanger","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"e01896-18","DOI":"10.1128\/AAC.01896-18","article-title":"Preexposure to Isavuconazole Increases the Virulence of Mucorales but Not Aspergillus fumigatus in a Drosophila melanogaster Infection Model","volume":"63","author":"Wurster","year":"2019","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1128\/AAC.50.1.96-103.2006","article-title":"Lovastatin has significant activity against zygomycetes and interacts synergistically with voriconazole","volume":"50","author":"Chamilos","year":"2006","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"5631","DOI":"10.1128\/AAC.00850-15","article-title":"Identification and characterization of a novel family of selective antifungal compounds (CANBEFs) that interfere with fungal protein synthesis","volume":"59","author":"Mircus","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1080\/21505594.2015.1021540","article-title":"Prolonged pre-incubation increases the susceptibility of Galleria mellonella larvae to bacterial and fungal infection","volume":"6","author":"Browne","year":"2015","journal-title":"Virulence"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"2428","DOI":"10.4081\/ejh.2014.2428","article-title":"A histological procedure to study fungal infection in the wax moth Galleria mellonella","volume":"58","author":"Perdoni","year":"2014","journal-title":"Eur. J. Histochem."},{"key":"ref_171","doi-asserted-by":"crossref","unstructured":"Skaar, E.P. (2010). The battle for iron between bacterial pathogens and their vertebrate hosts. PLoS Pathog., 6.","DOI":"10.1371\/journal.ppat.1000949"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.dci.2015.10.022","article-title":"Silkworm ferritin 1 heavy chain homolog is involved in defense against bacterial infection through regulation of haemolymph iron homeostasis","volume":"55","author":"Otho","year":"2016","journal-title":"Dev. Comp. Immunol."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1002\/iub.1211","article-title":"Iron homeostasis in insects: Insights from Drosophila studies","volume":"65","author":"Tang","year":"2013","journal-title":"IUBMB life"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1146\/annurev-phyto-080516-035537","article-title":"Iron and Immunity","volume":"55","author":"Verbon","year":"2017","journal-title":"Ann. Rev. Phytopathol."}],"container-title":["Journal of Fungi"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2309-608X\/5\/2\/27\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T12:41:02Z","timestamp":1760186462000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2309-608X\/5\/2\/27"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,27]]},"references-count":174,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2019,6]]}},"alternative-id":["jof5020027"],"URL":"https:\/\/doi.org\/10.3390\/jof5020027","relation":{},"ISSN":["2309-608X"],"issn-type":[{"value":"2309-608X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,27]]}}}