{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:45:08Z","timestamp":1792100708423,"version":"4.4.0"},"reference-count":70,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2020,8,20]],"date-time":"2020-08-20T00:00:00Z","timestamp":1597881600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>Fungal infections are becoming more prevalent and problematic due to the continual rise of immune deficient patients as well as the progressive development of drug resistance towards currently available antifungal drugs. There has been a significant increase in the development of antifungal compounds with a similar mechanism of action of current drugs. In contrast, there has been very little progress in developing compounds inhibiting totally new fungal targets or\/and fungal pathways. This review focuses on novel compounds recently discovered to target the fungal sphingolipids and their metabolizing enzymes.<\/jats:p>","DOI":"10.3390\/jof6030142","type":"journal-article","created":{"date-parts":[[2020,8,20]],"date-time":"2020-08-20T09:35:31Z","timestamp":1597916131000},"page":"142","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Antifungal Drug Development: Targeting the Fungal Sphingolipid Pathway"],"prefix":"10.3390","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8726-5655","authenticated-orcid":false,"given":"Kyle","family":"McEvoy","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Stony Brook University, Stony Brook, NY 11794, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyler","family":"Normile","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Stony Brook University, Stony Brook, NY 11794, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Del Poeta","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Stony Brook University, Stony Brook, NY 11794, USA"},{"name":"Division of Infectious Diseases, School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA"},{"name":"Veterans Administration Medical Center, Northport, NY 11768, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,8,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S352","DOI":"10.1093\/cid\/ciu639","article-title":"Update on epidemiology of and preventive strategies for invasive fungal infections in cancer patients","volume":"59","author":"Perfect","year":"2014","journal-title":"Clin. 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