{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:08:03Z","timestamp":1791644883147,"version":"4.3.4"},"reference-count":30,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2020,8,25]],"date-time":"2020-08-25T00:00:00Z","timestamp":1598313600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>In recent decades, emerging fungal infections have changed the clinical mycology scenario as a consequence of the advances in medical diagnostics and therapeutic procedures, long hospitalization times, and the growing number of individuals with debilitating chronic diseases and impaired immune systems. This report presents a 19 months old Brazilian female patient who developed a severe fungal sepsis by an uncommon yeast. She was admitted at the intensive care unit with severe pneumonia, bronchopulmonary dysplasia, and weight-for-age z score of less than \u22122. She remained more than 30 days in the intensive care unit where she had a femoral venous catheter placement, enteral nutrition, broad-spectrum antibiotic therapy, and prophylaxis with fluconazole. Moreover, pericardiocentesis was performed due to cardiac tamponade. She had a previous history of prematurity, cardiac surgery due to patent ductus arteriosus, and a long period of hospital stay. Despite the antifungal prophylaxis, two yeast isolates were recovered from blood and then identified by classical mycological methods and internal transcribed spacer (ITS) sequencing as Wickerhamomyces anomalus. Both isolates exhibited susceptibility to amphotericin B, ketoconazole, itraconazole, voriconazole, and fluconazole. Her clinical state worsened, presenting anasarca, epistaxis, and hemorrhagic suffusions in the mouth, sclera, oliguria, and bradycardia. Two days after the first positive culture, she presented a gradual reduction of the white blood cells count, with severe leukopenia and neutropenia. She died five days after.<\/jats:p>","DOI":"10.3390\/jof6030147","type":"journal-article","created":{"date-parts":[[2020,8,25]],"date-time":"2020-08-25T09:30:07Z","timestamp":1598347807000},"page":"147","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Fatal Case of Fungemia by Wickerhamomyces anomalus in a Pediatric Patient Diagnosed in a Teaching Hospital from Brazil"],"prefix":"10.3390","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2717-5818","authenticated-orcid":false,"given":"Vitor Rodrigues","family":"Dutra","sequence":"first","affiliation":[{"name":"Department of Microbiology, Immunology and Parasitology, Federal University of Triangulo Mineiro, Uberaba 38015-050, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8059-9575","authenticated-orcid":false,"given":"Leonardo Francisco","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Parasitology, Federal University of Triangulo Mineiro, Uberaba 38015-050, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana Nazar\u00e9 Miziara","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Federal University of Triangulo Mineiro, Uberaba 38025-440, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3317-0060","authenticated-orcid":false,"given":"Em\u00edlia Freitas","family":"Beirigo","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Parasitology, Federal University of Triangulo Mineiro, Uberaba 38015-050, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0283-6306","authenticated-orcid":false,"given":"Vanessa Mello","family":"Arthur","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Parasitology, Federal University of Triangulo Mineiro, Uberaba 38015-050, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2802-3808","authenticated-orcid":false,"given":"Ra\u00edssa","family":"Bernardes da Silva","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Parasitology, Federal University of Triangulo Mineiro, Uberaba 38015-050, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thatiana Bragine","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Federal University of Triangulo Mineiro, Uberaba 38025-440, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0485-229X","authenticated-orcid":false,"given":"Leonardo","family":"Andrade-Silva","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Federal University of Triangulo Mineiro, Uberaba 38025-440, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2966-7621","authenticated-orcid":false,"given":"Marcos Vin\u00edcius","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Parasitology, Federal University of Triangulo Mineiro, Uberaba 38015-050, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5326-0776","authenticated-orcid":false,"given":"Fernanda Machado","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Federal University of Triangulo Mineiro, Uberaba 38025-350, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario Le\u00f3n","family":"Silva-Vergara","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Federal University of Triangulo Mineiro, Uberaba 38025-440, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6035-8392","authenticated-orcid":false,"given":"Kennio","family":"Ferreira-Paim","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Parasitology, Federal University of Triangulo Mineiro, Uberaba 38015-050, Brazil"},{"name":"Department of Infectious Diseases, Federal University of Triangulo Mineiro, Uberaba 38025-440, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,8,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"267","DOI":"10.2217\/fmb-2018-0253","article-title":"First fungemia case 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