{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:48:04Z","timestamp":1790628484440,"version":"4.1.0"},"reference-count":147,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T00:00:00Z","timestamp":1605744000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>Paracoccidioidomycosis is a neglected disease that causes economic and social impacts, mainly affecting people of certain social segments, such as rural workers. The limitations of antifungals, such as toxicity, drug interactions, restricted routes of administration, and the reduced bioavailability in target tissues, have become evident in clinical settings. These factors, added to the fact that Paracoccidioidomycosis (PCM) therapy is a long process, lasting from months to years, emphasize the need for the research and development of new molecules. Researchers have concentrated efforts on the identification of new compounds using numerous tools and targeting important proteins from Paracoccidioides, with the emphasis on enzymatic pathways absent in humans. This review aims to discuss the aspects related to the identification of compounds, methodologies, and perspectives when proposing new antifungal agents against PCM.<\/jats:p>","DOI":"10.3390\/jof6040300","type":"journal-article","created":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T06:23:52Z","timestamp":1605767032000},"page":"300","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Overview of Antifungal Drugs against Paracoccidioidomycosis: How Do We Start, Where Are We, and Where Are We Going?"],"prefix":"10.3390","volume":"6","author":[{"given":"L\u00edvia","family":"do Carmo Silva","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Biology, Institute of Biological Sciences, Federal University of Goi\u00e1s, Goi\u00e2nia 74690-900, GO, Brazil"},{"name":"Institute of Tropical Pathology and Public Health, Federal University of Goi\u00e1s, Goi\u00e2nia 74605-050, GO, 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Lohany Barros","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology, Institute of Biological Sciences, Federal University of Goi\u00e1s, Goi\u00e2nia 74690-900, GO, Brazil"},{"name":"Institute of Tropical Pathology and Public Health, Federal University of Goi\u00e1s, Goi\u00e2nia 74605-050, GO, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5350-7313","authenticated-orcid":false,"given":"Kleber Santiago","family":"Freitas e Silva","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology, Institute of Biological Sciences, Federal University of Goi\u00e1s, Goi\u00e2nia 74690-900, GO, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1513-3247","authenticated-orcid":false,"given":"Marcos Antonio Batista","family":"Carvalho J\u00fanior","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular 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Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thaynara Gonzaga","family":"Santos","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology, Institute of Biological Sciences, Federal University of Goi\u00e1s, Goi\u00e2nia 74690-900, GO, Brazil"},{"name":"Institute of Tropical Pathology and Public Health, Federal University of Goi\u00e1s, Goi\u00e2nia 74605-050, GO, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5378-9840","authenticated-orcid":false,"given":"C\u00e9lia Maria de Almeida","family":"Soares","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology, Institute of Biological Sciences, Federal University of Goi\u00e1s, Goi\u00e2nia 74690-900, GO, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maristela","family":"Pereira","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology, Institute of Biological 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