{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T11:04:25Z","timestamp":1774436665785,"version":"3.50.1"},"reference-count":18,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T00:00:00Z","timestamp":1606262400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004561","name":"Ministry of Education and Science of the Republic of Kazakhstan","doi-asserted-by":"publisher","award":["No. 0112RK01358 for 2012-2014"],"award-info":[{"award-number":["No. 0112RK01358 for 2012-2014"]}],"id":[{"id":"10.13039\/501100004561","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>We report the first case of non-dermatophytic onychomycosis of the toenail described in Kazakhstan caused by Candida parapsilosis. The biological properties of the strain were studied. C. parapsilosis forms white creamy colonies, smooth with focal wrinkles, and the reversum is light-yellow. The culture of C. parapsilosis is represented by a yeast form, characterized by the presence of round or cylindrical yeast cells with active budding. The strain has a high saccharolytic and urease activity and is indifferent to the sucrose and maltose. The C. parapsilosis strain was sensitive to polyene and azole antifungal agents. The highest sensitivity was found to ketoconazole, itraconazole and nystatin.<\/jats:p>","DOI":"10.3390\/jof6040313","type":"journal-article","created":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T08:59:15Z","timestamp":1606294755000},"page":"313","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Candida parapsilosis as a Causative Agent of Onychomycosis in Patient with Cirrhosis of the Liver"],"prefix":"10.3390","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3794-434X","authenticated-orcid":false,"given":"Yelena","family":"Kukhar","sequence":"first","affiliation":[{"name":"Department of Microbiology and Biotechnology, S. Seifullin Kazakh Agrotechnical University, Nur-Sultan 010000, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ainura","family":"Smagulova","sequence":"additional","affiliation":[{"name":"Research platform of Agricultural Biotechnology, S. Seifullin Kazakh Agrotechnical University, Nur-Sultan 010000, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ainash","family":"Daniyarova","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Biotechnology, S. Seifullin Kazakh Agrotechnical University, Nur-Sultan 010000, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4967-2804","authenticated-orcid":false,"given":"Aliya","family":"Baiduissenova","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Virology and Immunology, Astana Medical University, Nur-Sultan 010000, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9787-9151","authenticated-orcid":false,"given":"Vladimir","family":"Kiyan","sequence":"additional","affiliation":[{"name":"Research platform of Agricultural Biotechnology, S. Seifullin Kazakh Agrotechnical University, Nur-Sultan 010000, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,11,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1093\/mmy\/myy096","article-title":"Epidemiological survey of onychomycosis pathogens in Japan by real-time PCR","volume":"57","author":"Shimoyama","year":"2019","journal-title":"Med. Mycol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.mmcr.2019.04.012","article-title":"Different toenail onychomycosis due to Rhodotorula mucilaginosa and Candida parapsilosis in an immunocompetent young adult","volume":"24","author":"Ge","year":"2019","journal-title":"Med. Mycol Case Rep."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1007\/s42770-019-00096-0","article-title":"Mycoses in northeastern Brazil: Epidemiology and prevalence of fungal species in 8 years of retrospective analysis in Alagoas","volume":"50","author":"Silva","year":"2019","journal-title":"Braz. J. Microbiol."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Richardson, M.D., and Warnock, D.W. (2012). Fungal Infection: Diagnosis and Management, John Wiley & Sons Ltd.. [4th ed.].","DOI":"10.1002\/9781118321492"},{"key":"ref_5","first-page":"41","article-title":"Fungal infections of the nail","volume":"10","author":"Haneke","year":"1991","journal-title":"Semin. Dermatol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1002\/jcla.21973","article-title":"Causative agents of onychomycosis: A 7-year study","volume":"30","author":"Chadeganipour","year":"2016","journal-title":"J. Clin. Lab. Anal."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1046\/j.1439-0507.2000.00582.x","article-title":"The frequency of Candida parapsilosis in onychomycosis. An epidemiological survey in Israel","volume":"43","author":"Segal","year":"2000","journal-title":"Mycoses"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1111\/j.1365-4632.2004.02125.x","article-title":"Onychomycosis in central India: A clinicoetiologic correlation","volume":"43","author":"Garg","year":"2004","journal-title":"Int. J. Dermatol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.mmcr.2019.04.005","article-title":"Onychomycosis with greenish-black discolorations and recurrent onycholysis caused by Candida parapsilosis","volume":"24","author":"Ge","year":"2019","journal-title":"Med. Mycol. Case Rep."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1111\/j.1439-0507.2000.00602.x","article-title":"Case report and review. Onychomycosis due to Candida parapsilosis","volume":"43","author":"Gautret","year":"2000","journal-title":"Mycoses"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Hosuru, S.S., Hamal, D., Nayak, N., and Gokhale, S. (2016). Onychomycosis due to Candida parapsilosis in a child with ventricular septal defect: An unusual predisposition. Case Rep. Pediatr., 7026068.","DOI":"10.1155\/2016\/7026068"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/j.1525-1470.2007.00365.x","article-title":"Onychomycosis in a premature infant caused by Candida parapsilosis","volume":"24","author":"Koklu","year":"2007","journal-title":"Pediatr. Dermatol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"24","DOI":"10.4103\/0019-5154.123485","article-title":"Candida parapsilosis and Candida guillermondii: Emerging pathogens in nail candidiasis","volume":"59","author":"Fich","year":"2014","journal-title":"Indian J. Dermatol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1128\/CMR.00013-08","article-title":"Candida parapsilosis, an emerging fungal pathogen","volume":"21","author":"Trofa","year":"2008","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_15","unstructured":"Sutton, D., Fothergill, A., and Rinaldi, M. (2001). The Determinant of Pathogenic and Conditionally Pathogenic Fungi, The World."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1590\/S1413-86702008000400016","article-title":"Successive mycological nail tests for onychomycosis: A strategy to improve diagnosis efficiency","volume":"12","author":"Cordeiro","year":"2008","journal-title":"Braz. J. Infect. Dis."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1099\/mic.0.27739-0","article-title":"Phenotype switching affects biofilm formation by Candida parapsilosis","volume":"151","author":"Laffey","year":"2005","journal-title":"Microbiology"},{"key":"ref_18","first-page":"217","article-title":"Asymmetric gait nail unit syndrome: The most common worldwide toenail abnormality and onychomycosis","volume":"12","author":"Zaias","year":"2014","journal-title":"Skinmed"}],"container-title":["Journal of Fungi"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2309-608X\/6\/4\/313\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:37:06Z","timestamp":1760179026000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2309-608X\/6\/4\/313"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,25]]},"references-count":18,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2020,12]]}},"alternative-id":["jof6040313"],"URL":"https:\/\/doi.org\/10.3390\/jof6040313","relation":{},"ISSN":["2309-608X"],"issn-type":[{"value":"2309-608X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,25]]}}}