{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T22:03:38Z","timestamp":1792447418755,"version":"4.5.0"},"reference-count":65,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2020,11,27]],"date-time":"2020-11-27T00:00:00Z","timestamp":1606435200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>The continuous increase of Coccidioidomycosis cases requires reliable detection methods of the causal agent, Coccidioides spp., in its natural environment. This has proven challenging because of our limited knowledge on the distribution of this soil-dwelling fungus. Knowing the pathogen\u2019s geographic distribution and its relationship with the environment is crucial to identify potential areas of risk and to prevent disease outbreaks. The maximum entropy (Maxent) algorithm, Geographic Information System (GIS) and bioclimatic variables were combined to obtain current and future potential distribution models (DMs) of Coccidioides and its putative rodent reservoirs for Arizona, California and Baja California. We revealed that Coccidioides DMs constructed with presence records from one state are not well suited to predict distribution in another state, supporting the existence of distinct phylogeographic populations of Coccidioides. A great correlation between Coccidioides DMs and United States counties with high Coccidioidomycosis incidence was found. Remarkably, under future scenarios of climate change and high concentration of greenhouse gases, the probability of habitat suitability for Coccidioides increased. Overlap analysis between the DMs of rodents and Coccidioides, identified Neotoma lepida as one of the predominant co-occurring species in all three states. Considering rodents DMs would allow to implement better surveillance programs to monitor disease spread.<\/jats:p>","DOI":"10.3390\/jof6040320","type":"journal-article","created":{"date-parts":[[2020,11,28]],"date-time":"2020-11-28T03:51:16Z","timestamp":1606535476000},"page":"320","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Of Mice and Fungi: Coccidioides spp. Distribution Models"],"prefix":"10.3390","volume":"6","author":[{"given":"Pamela","family":"Ocampo-Chavira","sequence":"first","affiliation":[{"name":"Department of Microbiology, Centro de Investigaci\u00f3n Cient\u00edfica y Educaci\u00f3n Superior de Ensenada (CICESE), Ctra. Ensenada-Tijuana No. 3918, Ensenada, Baja California 22860, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Eaton-Gonzalez","sequence":"additional","affiliation":[{"name":"Academic Unit of Ensenada, Universidad Tecnol\u00f3gica de Tijuana, Ctra. a la Bufadora KM. 1, Maneadero Parte Alta, Ensenada, Baja California 22790, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2580-326X","authenticated-orcid":false,"given":"Meritxell","family":"Riquelme","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Centro de Investigaci\u00f3n Cient\u00edfica y Educaci\u00f3n Superior de Ensenada (CICESE), Ctra. Ensenada-Tijuana No. 3918, Ensenada, Baja California 22860, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,11,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.funeco.2011.08.004","article-title":"Molecular detection of Coccidioides spp. from environmental samples in Baja California: Linking Valley Fever to soil and climate conditions","volume":"5","author":"Hinojosa","year":"2012","journal-title":"Fungal Ecol."},{"key":"ref_2","first-page":"14","article-title":"Crossing the line: Human disease and climate change across borders","volume":"81","author":"Cat","year":"2019","journal-title":"Adv. Sci."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1023\/A:1007619813435","article-title":"Environmental variability and coccidioidomycosis (valley fever)","volume":"17","author":"Kolivras","year":"2001","journal-title":"Aerobiologia"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1128\/jb.87.3.500-503.1964","article-title":"Significance of soil salinity on the ecology of Coccidioides immitis","volume":"87","author":"Elconin","year":"1963","journal-title":"J. Bacteriol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1128\/am.27.2.379-388.1974","article-title":"Soil ecology of Coccidioides immitis at Amerindian Middens in California","volume":"27","author":"Lacy","year":"1974","journal-title":"Appl. Microbiol."},{"key":"ref_6","first-page":"21","article-title":"Bioclimatolog\u00eda de la coccidioidomicosis en Baja California, M\u00e9xico","volume":"71","author":"Riquelme","year":"2010","journal-title":"Bolet\u00edn Inst. Geogr. Unam"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1289\/ehp.7786","article-title":"Climate factors influencing Coccidioidomycosis seasonality and outbreaks","volume":"113","author":"Comrie","year":"2005","journal-title":"Environ. Health Perspect."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Tamerius, J.D., and Comrie, C.A. (2011). Coccidioidomycosis incidence in Arizona predicted by seasonal precipitation. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0021009"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1196\/annals.1406.031","article-title":"Coccidioides niches and habitat parameters in the Southwestern United States: A matter of scale","volume":"1111","author":"Fisher","year":"2007","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"10081","DOI":"10.5194\/acp-13-10081-2013","article-title":"Expansion of global drylands under a warming climate","volume":"13","author":"Feng","year":"2013","journal-title":"Atmos. Chem. Phys."},{"key":"ref_11","unstructured":"Stocker, T., Qin, D., Plattner, G., Tignor, M., Allen, S., Boschung, J., Nauels, A., Xia, Y., Bex, V., and Midgley, P. (2013). Intergovernmental Panel on Climate Change: Climate Change 2013: The Physical Science Basis. Contribution of Working Group I to the Fifth Assessment Report of the Intergovernmental Panel on Climate Change, Cambridge University Press."},{"key":"ref_12","unstructured":"Solomon, S., Qin, D., Manning, M., Chen, Z., Marquis, M., Averyt, K., Tignor, M., and Miller, H. (2007). Intergovernmental Panel on Climate Change. Summary for Policymakers. Climate Change 2007: The Physical Science Basis. Contribution of Working Group I to the Fourth Assessment Report of the Intergovernmental Panel on Climate Change, Cambridge University Press."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/416389a","article-title":"Ecological responses to recent climate change","volume":"416","author":"Post","year":"2002","journal-title":"Nature"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/nature01286","article-title":"A globally coherent fingerprint of climate change impacts across natural systems","volume":"421","author":"Parmesan","year":"2003","journal-title":"Nature"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1890\/11-0026.1","article-title":"Responses of soil microbial communities to water stress: Results from a meta-analysis","volume":"93","author":"Manzoni","year":"2012","journal-title":"Ecology"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"294","DOI":"10.3389\/fmicb.2018.00294","article-title":"Drought legacy effects on the composition of soil fungal and prokaryote communities","volume":"9","author":"Meisner","year":"2018","journal-title":"Front. Microbiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"579","DOI":"10.3389\/fmicb.2014.00579","article-title":"Untangling the fungal niche: The trait-based approach","volume":"5","author":"Crowther","year":"2014","journal-title":"Front. Microbiol."},{"key":"ref_18","first-page":"550","article-title":"The habitat of Coccidioides spp. and the role of animals as reservoirs and disseminators in nature","volume":"16","author":"Arenas","year":"2016","journal-title":"Biomed. Cent. Infect. Disseases"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Lauer, A., Talamantes, J., Casta\u00f1\u00f3n-Olivares, L.R., Jaime, M.L., Hugo-Baal, J.D., Casimiro, K., Shroff, N., and Emery, K.W. (2014). Combining forces: The use of Landsat TM satellite imagery, soil parameter information, and multiplex PCR to detect Coccidioides immitis growth sites in Kern County, California. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0111921"},{"key":"ref_20","first-page":"3","article-title":"Ecology of Coccidioides immitis","volume":"40","author":"Swatek","year":"1970","journal-title":"Mycopathologia"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1101\/gr.087551.108","article-title":"Comparative genomic analyses of the human fungal pathogens Coccidioides and their relatives","volume":"19","author":"Sharpton","year":"2009","journal-title":"Genome Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1086\/313602","article-title":"Outbreak of coccidioidomycosis in Washington state residents returning from Mexico","volume":"30","author":"Cairns","year":"2000","journal-title":"Clin. Infect. Dis."},{"key":"ref_23","first-page":"1","article-title":"Impact of seasonal changes on fungal diversity of a semi-arid ecosystem revealed by 454 pyrosequencing","volume":"91","author":"Escalante","year":"2015","journal-title":"FEMS Microbiol. Ecol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.funbio.2014.01.006","article-title":"Detection of coccidioidal antibodies in serum of a small rodent community in Baja California, Mexico","volume":"118","author":"Johnson","year":"2014","journal-title":"Fungal Biol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"109","DOI":"10.2307\/4583988","article-title":"Isolation of Coccidioides from soil and rodents","volume":"57","author":"Emmons","year":"1942","journal-title":"Public Health Rep."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.ecolmodel.2005.03.026","article-title":"Maximum entropy modeling of species geographic distributions","volume":"190","author":"Phillips","year":"2006","journal-title":"Ecol. Model."},{"key":"ref_27","unstructured":"Pearson, R.G. (2007). Species Distribution Modeling for Conservation Educators and Practitioners, American Museum of Natural History."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.fbr.2020.01.002","article-title":"Using species distribution models for Fungi","volume":"34","author":"Hao","year":"2020","journal-title":"Fungal Biol. Rev."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1196\/annals.1406.003","article-title":"Ecological niche modeling of Coccidioides spp. in Western North American deserts","volume":"1111","author":"Hinojosa","year":"2007","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1111\/geb.12268","article-title":"Matching distribution models to applications","volume":"24","author":"Elith","year":"2015","journal-title":"Glob. Ecol. Biogeogr."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Acharya, B.K., Cao, C., Xu, M., Khanal, L., Naeem, S., and Pandit, S. (2018). Present and Future of Dengue Fever in Nepal: Mapping Climatic Suitability by Ecological Niche Model. Int J. Env. Res. Public Health, 15.","DOI":"10.3390\/ijerph15020187"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/nature12060","article-title":"The global distribution and burden of dengue","volume":"496","author":"Bhatt","year":"2013","journal-title":"Nature"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1093\/mmy\/myy007","article-title":"Direct detection of Coccidioides from Arizona soils using CocciENV, a highly sensitive and specific real-time PCR assay","volume":"57","author":"Bowers","year":"2018","journal-title":"Med. Mycol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"4302","DOI":"10.1002\/joc.5086","article-title":"Worldclim 2: New 1-Km spatial resolution climate surfaces for global land areas","volume":"37","author":"Fick","year":"2017","journal-title":"Int. J. Climatol."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Hengl, T., Mendes de Jesus, J., Heuvelink, G.B.M., Ruiperez-Gonzalez, M., Kilibarda, M., and Blagotic, A. (2017). Soilgrids250m: Global gridded soil information based on machine learning. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0169748"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s10584-011-0148-z","article-title":"The representative concentration pathways: An overview","volume":"109","author":"Edmonds","year":"2011","journal-title":"Clim. Chang."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1002\/joc.1276","article-title":"Very high resolution interpolated climate surfaces for global land areas","volume":"25","author":"Hijmans","year":"2005","journal-title":"Int. J. Climatol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.techfore.2006.05.026","article-title":"Scenarios of long-term socio-economic and environmental development under climate stabilization","volume":"74","author":"Riahi","year":"2007","journal-title":"Technol. Forecast. Soc. Chang."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s10584-011-0149-y","article-title":"A scenario of comparatively high greenhouse gas emissions","volume":"109","author":"Riahi","year":"2011","journal-title":"Clim. Chang."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"e3477","DOI":"10.7717\/peerj.3477","article-title":"Predicting suitable habitat of the Chinese monal (Lophophorus lhuysii) using ecological niche modeling in the Qionglai Mountains, China","volume":"5","author":"Wang","year":"2017","journal-title":"PeerJ"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/j.1365-2915.2010.00935.x","article-title":"Evaluation of species distribution model algorithms for fine-scale container-breeding mosquito risk prediction","volume":"25","author":"Khatchikian","year":"2011","journal-title":"Med. Vet. Entomol."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Fourcade, Y., Engler, J.O., R\u00f6dder, D., and Secondi, J. (2014). Mapping species distributions with MAXENT using a geographically biased sample of presence data: A performance assessment of methods for correcting sampling bias. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0097122"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"McGaughran, A., Morgan, K., and Sommer, R.J. (2014). Environmental variables explain genetic structure in a beetle-associated nematode. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0087317"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"52","DOI":"10.3390\/d1010052","article-title":"Global amphibian extinction risk assessment for the panzootic Chytrid fungus","volume":"1","author":"Kielgast","year":"2009","journal-title":"Diversity"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1111\/j.1365-2486.2005.01000.x","article-title":"Validation of species\u2013climate impact models under climate change","volume":"11","author":"Pearson","year":"2005","journal-title":"Glob. Chang. Biol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.3201\/eid2206.151565","article-title":"Use of population genetics to assess the ecology, evolution, and population structure of Coccidioides","volume":"22","author":"Teixeira","year":"2016","journal-title":"Emerg. Infect. Dis."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"4558","DOI":"10.1073\/pnas.071406098","article-title":"Biogeographic range expansion into South America by Coccidioides immitis mirrors New World patterns of human migration","volume":"98","author":"Fisher","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0378-1127(99)00290-X","article-title":"Predicting spatial and temporal patterns of soil temperature based on topography, surface cover and air temperature","volume":"136","author":"Kang","year":"2000","journal-title":"For. Ecol. Manag."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2898","DOI":"10.1111\/j.1365-2486.2008.01716.x","article-title":"Warming and drying suppress microbial activity and carbon cycling in boreal forest soils","volume":"14","author":"Allison","year":"2008","journal-title":"Glob. Chang. Biol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"3395","DOI":"10.1111\/gcb.13238","article-title":"Experimental warming alters potential function of the fungal community in boreal forest","volume":"22","author":"Treseder","year":"2016","journal-title":"Glob. Chang. Biol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"e02851","DOI":"10.7554\/eLife.02851","article-title":"Global distribution maps of the leishmaniases","volume":"3","author":"Pigott","year":"2014","journal-title":"eLife"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/j.1365-2664.2010.01890.x","article-title":"Assessing spatial patterns of disease risk to biodiversity: Implications for the management of the amphibian pathogen, Batrachochytrium dendrobatidis","volume":"48","author":"Murray","year":"2011","journal-title":"J. Appl. Ecol."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Moffett, A., Shackelford, N., and Sarkar, S. (2007). Malaria in Africa: Vector species\u2019 niche models and relative risk maps. PLoS ONE, 2.","DOI":"10.1371\/journal.pone.0000824"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"e15272","DOI":"10.7554\/eLife.15272","article-title":"Mapping global environmental suitability for Zika virus","volume":"5","author":"Messina","year":"2016","journal-title":"eLife"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1126\/science.1137489","article-title":"Rapid and recent changes in fungal fruiting patterns","volume":"316","author":"Gange","year":"2012","journal-title":"Science"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Pachauri, R.K., and Resinger, A. (2007). Climate Change 2007: Synthesis Report, Intergovermental Panel on Climate Change.","DOI":"10.1017\/CBO9780511546013"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/nature10947","article-title":"Emerging fungal threats to animal, plant and ecosystem health","volume":"484","author":"Fisher","year":"2012","journal-title":"Nature"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1126\/science.3287615","article-title":"Measuring the accuracy of diagnotic systems","volume":"240","author":"Swets","year":"1988","journal-title":"Science"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0304-3800(01)00388-X","article-title":"Effects of sample size on accuracy of species distribution models","volume":"148","author":"Stockwell","year":"2002","journal-title":"Ecol. Model."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"62","DOI":"10.3852\/11-127","article-title":"Detection of Coccidioides immitis in Kern County, California, by multiplex PCR","volume":"104","author":"Lauer","year":"2011","journal-title":"Mycologia"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/cid\/ciu681","article-title":"Valley fever: Finding new places for an old disease: Coccidioides immitis found in Washington State soil associated with recent human infection","volume":"60","author":"Litvintseva","year":"2015","journal-title":"Clin. Infect. Dis."},{"key":"ref_62","first-page":"527","article-title":"Tempest from Tehachapi takes toll Coccidioides conveyed aloft and afar","volume":"129","author":"Pappagianis","year":"1978","journal-title":"West. J. Med."},{"key":"ref_63","first-page":"44","article-title":"The probable geographic distribution of Coccidioides immitis in Mexico","volume":"57","author":"Maddy","year":"1964","journal-title":"Bol. De La Oficina Sanit. Panam."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"S16","DOI":"10.1093\/mmy\/myy039","article-title":"The endozoan, small-mammal reservoir hypothesis and the life cycle of Coccidioides species","volume":"57","author":"Taylor","year":"2019","journal-title":"Med. Mycol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"5904","DOI":"10.1175\/JCLI-D-11-00425.1","article-title":"Downscaled climate change scenarios for Baja California and the North American monsoon during the 21st century","volume":"25","author":"Cavazos","year":"2012","journal-title":"J. Clim."}],"container-title":["Journal of Fungi"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2309-608X\/6\/4\/320\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:38:39Z","timestamp":1760179119000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2309-608X\/6\/4\/320"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,27]]},"references-count":65,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2020,12]]}},"alternative-id":["jof6040320"],"URL":"https:\/\/doi.org\/10.3390\/jof6040320","relation":{},"ISSN":["2309-608X"],"issn-type":[{"value":"2309-608X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,27]]}}}