{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:18:44Z","timestamp":1790381924384,"version":"4.1.0"},"reference-count":46,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,1,5]],"date-time":"2021-01-05T00:00:00Z","timestamp":1609804800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>Data concerning the incidence of invasive aspergillosis (IA) in high-risk patients in Greece are scarce, while the impact of the revised 2020 EORTC\/MSGERC consensus criteria definitions on the reported incidence rate of IA remains unknown. A total of 93 adult hematology patients were screened for IA for six months in four tertiary care Greek hospitals. Serial serum specimens (n = 240) the sample was considered negative by PCR were collected twice-weekly and tested for galactomannan (GM) and Aspergillus DNA (PCR) detection. IA was defined according to both the 2008 EORTC\/MSG and the 2020 EORTC\/MSGERC consensus criteria. Based on the 2008 EORTC\/MSG criteria, the incidence rates of probable and possible IA was 9\/93 (10%) and 24\/93 (26%), respectively, while no proven IA was documented. Acute myeloid leukemia was the most (67%) common underlying disease with most (82%) patients being on antifungal prophylaxis\/treatment. Based on the new 2020 EORTC\/MSGERC criteria, 2\/9 (22%) of probable and 1\/24 (4%) of possible cases should be reclassified as possible and probable, respectively. The episodes of probable IA were reduced by 33% when GM alone and 11% when GM + PCR were used as mycological criterion. The incidence rate of IA in hematology patients was 10%. Application of the 2020 EORTC\/MSGERC updated criteria results in a reduction in the classification of probable IA particularly when PCR is not available.<\/jats:p>","DOI":"10.3390\/jof7010027","type":"journal-article","created":{"date-parts":[[2021,1,5]],"date-time":"2021-01-05T21:18:57Z","timestamp":1609881537000},"page":"27","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["A Prospective Multicenter Cohort Surveillance Study of Invasive Aspergillosis in Patients with Hematologic Malignancies in Greece: Impact of the Revised EORTC\/MSGERC 2020 Criteria"],"prefix":"10.3390","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5924-1007","authenticated-orcid":false,"given":"Maria","family":"Siopi","sequence":"first","affiliation":[{"name":"Clinical Microbiology Laboratory, \u201cAttikon\u201d University General Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1793-6617","authenticated-orcid":false,"given":"Stamatis","family":"Karakatsanis","sequence":"additional","affiliation":[{"name":"Department of Hematology and Lymphoma, Unit of Bone Marrow Transplantation, \u201cEvangelismos\u201d General Hospital, 10676 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoforos","family":"Roumpakis","sequence":"additional","affiliation":[{"name":"2nd Department of Internal Medicine, Hematology Unit, \u201cAttikon\u201d University General Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Korantanis","sequence":"additional","affiliation":[{"name":"Pathophysiology Department, \u201cLaiko\u201d General Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8904-076X","authenticated-orcid":false,"given":"Helen","family":"Sambatakou","sequence":"additional","affiliation":[{"name":"2nd Department of Internal Medicine, \u201cHippokration\u201d General Hospital, 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6955-3453","authenticated-orcid":false,"given":"Nikolaos V.","family":"Sipsas","sequence":"additional","affiliation":[{"name":"Pathophysiology Department, \u201cLaiko\u201d General Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiotis","family":"Tsirigotis","sequence":"additional","affiliation":[{"name":"2nd Department of Internal Medicine, Hematology Unit, \u201cAttikon\u201d University General Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Pagoni","sequence":"additional","affiliation":[{"name":"Department of Hematology and Lymphoma, Unit of Bone Marrow Transplantation, \u201cEvangelismos\u201d General Hospital, 10676 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8869-1509","authenticated-orcid":false,"given":"Joseph","family":"Meletiadis","sequence":"additional","affiliation":[{"name":"Clinical Microbiology Laboratory, \u201cAttikon\u201d University General Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,1,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e2018063","DOI":"10.4084\/mjhid.2018.063","article-title":"Invasive fungal infections in patients with chronic lymphoproliferative disorders in the era of target drugs","volume":"10","author":"Facchinelli","year":"2018","journal-title":"Mediterr. 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