{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:43:54Z","timestamp":1790700234651,"version":"4.1.0"},"reference-count":80,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,1,6]],"date-time":"2021-01-06T00:00:00Z","timestamp":1609891200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"CEREDIH, Paris, France","award":["2017"],"award-info":[{"award-number":["2017"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>Establishment of a fungal infection due to Aspergillus fumigatus relies on the efficient germination of the airborne conidia once they penetrate the respiratory tract. However, the features of conidial germination have been poorly explored and understood in this fungal species as well as in other species of filamentous fungi. We show here that the germination of A. fumigatus is asynchronous. If the nutritional environment and extensive gene deletions can modify the germination parameters for A. fumigatus, the asynchrony is maintained in all germinative conditions tested. Even though the causes for this asynchrony of conidial germination remain unknown, asynchrony is essential for the completion of the biological cycle of this filamentous fungus.<\/jats:p>","DOI":"10.3390\/jof7010030","type":"journal-article","created":{"date-parts":[[2021,1,6]],"date-time":"2021-01-06T20:45:42Z","timestamp":1609965942000},"page":"30","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Aspergillus fumigatus, One Uninucleate Species with Disparate Offspring"],"prefix":"10.3390","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3907-0658","authenticated-orcid":false,"given":"Fran\u00e7ois","family":"Danion","sequence":"first","affiliation":[{"name":"Unit\u00e9 des Aspergillus, Institut Pasteur, 75015 Paris, France"},{"name":"Centre d\u2019infectiologie Necker Pasteur, H\u00f4pital Necker-Enfants Malades, 75015 Paris, France"},{"name":"Department of Infectious Diseases, CHU Strasbourg, 67000 Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6722-2757","authenticated-orcid":false,"given":"Norman","family":"van Rhijn","sequence":"additional","affiliation":[{"name":"Manchester Fungal Infection Group, University of Manchester, Manchester M13 9PL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9417-7389","authenticated-orcid":false,"given":"Alexandre C.","family":"Dufour","sequence":"additional","affiliation":[{"name":"Bioimage Analysis Unit, Institut Pasteur, CNRS UMR3691, 75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Legendre","sequence":"additional","affiliation":[{"name":"Centre de Ressources et Recherches Technologiques (C2RT), Institut Pasteur, Plate-Forme Transcriptome et Epigenome, Biomics, 75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Odile","family":"Sismeiro","sequence":"additional","affiliation":[{"name":"Centre de Ressources et Recherches Technologiques (C2RT), Institut Pasteur, Plate-Forme Transcriptome et Epigenome, Biomics, 75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3980-4463","authenticated-orcid":false,"given":"Hugo","family":"Varet","sequence":"additional","affiliation":[{"name":"Centre de Ressources et Recherches Technologiques (C2RT), Institut Pasteur, Plate-Forme Transcriptome et Epigenome, Biomics, 75015 Paris, France"},{"name":"D\u00e9partement Biologie Computationnelle, Hub de Bioinformatique et Biostatistique, Institut Pasteur, USR 3756 CNRS, 75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6796-0696","authenticated-orcid":false,"given":"Jean-Christophe","family":"Olivo-Marin","sequence":"additional","affiliation":[{"name":"Bioimage Analysis Unit, Institut Pasteur, CNRS UMR3691, 75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Mouyna","sequence":"additional","affiliation":[{"name":"Unit\u00e9 des Aspergillus, Institut Pasteur, 75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Chamilos","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biology and Biotechnology FORTH and School of Medicine, University of Crete, 70013 Heraklion, Crete, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Bromley","sequence":"additional","affiliation":[{"name":"Manchester Fungal Infection Group, University of Manchester, Manchester M13 9PL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Beauvais","sequence":"additional","affiliation":[{"name":"Unit\u00e9 des Aspergillus, Institut Pasteur, 75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Paul","family":"Latg\u00e9","sequence":"additional","affiliation":[{"name":"Unit\u00e9 des Aspergillus, Institut Pasteur, 75015 Paris, France"},{"name":"Institute of Molecular Biology and Biotechnology FORTH and School of Medicine, University of Crete, 70013 Heraklion, Crete, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,1,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Lamarre, C., Sokol, S., Debeaupuis, J.-P., Henry, C., Lacroix, C., Glaser, P., Copp\u00e9e, J.-Y., Fran\u00e7ois, J.-M., and Latg\u00e9, J.-P. 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