{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:05:40Z","timestamp":1792789540735,"version":"4.5.0"},"reference-count":54,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T00:00:00Z","timestamp":1609977600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003451","name":"Universidad del Pa\u00eds Vasco","doi-asserted-by":"publisher","award":["ZabaldUz program"],"award-info":[{"award-number":["ZabaldUz program"]}],"id":[{"id":"10.13039\/501100003451","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Consejer\u00eda de Educaci\u00f3n, Universidades e Investigaci\u00f3n of Gobierno Vasco-Eusko Jaurlaritza","award":["GIC15\/78 IT-990-16"],"award-info":[{"award-number":["GIC15\/78 IT-990-16"]}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["SAF2013-47570-P, SAF2017-86188-P"],"award-info":[{"award-number":["SAF2013-47570-P, SAF2017-86188-P"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["SAF2017-86188-P"],"award-info":[{"award-number":["SAF2017-86188-P"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"name":"FP7-PEOPLE-2013-ITN\u2014Marie-Curie Action: \u201cInitial Training Networks\u201d","award":["MC-ITN-606786"],"award-info":[{"award-number":["MC-ITN-606786"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>Candida parapsilosis is a frequent cause of fungal bloodstream infections, especially in critically ill neonates or immunocompromised patients. Due to the formation of biofilms, the use of indwelling catheters and other medical devices increases the risk of infection and complicates treatment, as cells embedded in biofilms display reduced drug susceptibility. Therefore, biofilm formation may be a significant clinical parameter, guiding downstream therapeutic choices. Here, we phenotypically characterized 120 selected isolates out of a prospective collection of 215 clinical C. parapsilosis isolates, determining biofilm formation, major emerging colony morphotype, and antifungal drug susceptibility of the isolates and their biofilms. In our isolate set, increased biofilm formation capacity was independent of body site of isolation and not predictable using standard or modified European Committee on Antimicrobial Susceptibility Testing (EUCAST) drug susceptibility testing protocols. In contrast, biofilm formation was strongly correlated with the appearance of non-smooth colony morphotypes and invasiveness into agar plates. Our data suggest that the observation of non-smooth colony morphotypes in cultures of C. parapsilosis may help as an indicator to consider the initiation of anti-biofilm-active therapy, such as the switch from azole- to echinocandin- or polyene-based strategies, especially in case of infections by potent biofilm-forming strains.<\/jats:p>","DOI":"10.3390\/jof7010033","type":"journal-article","created":{"date-parts":[[2021,1,10]],"date-time":"2021-01-10T19:55:56Z","timestamp":1610308556000},"page":"33","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Candida parapsilosis Colony Morphotype Forecasts Biofilm Formation of Clinical Isolates"],"prefix":"10.3390","volume":"7","author":[{"given":"Emilia","family":"G\u00f3mez-Molero","sequence":"first","affiliation":[{"name":"Institute for Medical Microbiology, University Medical Center G\u00f6ttingen, Kreuzbergring 57, 37075 G\u00f6ttingen, Germany"},{"name":"Regional Center for Biomedical Research, Castilla-La Mancha Science &amp; Technology Park, University of Castilla\u2013La Mancha, 02008 Albacete, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iker","family":"De-la-Pinta","sequence":"additional","affiliation":[{"name":"Department of Immunology, Microbiology and Parasitology, School of Medicine and Nursing, Universidad del Pa\u00eds Vasco (UPV\/EHU), 48940 Bilbao, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan","family":"Fern\u00e1ndez-Pereira","sequence":"additional","affiliation":[{"name":"Regional Center for Biomedical Research, Castilla-La Mancha Science &amp; Technology Park, University of Castilla\u2013La Mancha, 02008 Albacete, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Gro\u00df","sequence":"additional","affiliation":[{"name":"Institute for Medical Microbiology, University Medical Center G\u00f6ttingen, Kreuzbergring 57, 37075 G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Weig","sequence":"additional","affiliation":[{"name":"Institute for Medical Microbiology, University Medical Center G\u00f6ttingen, Kreuzbergring 57, 37075 G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0438-2248","authenticated-orcid":false,"given":"Guillermo","family":"Quind\u00f3s","sequence":"additional","affiliation":[{"name":"Department of Immunology, Microbiology and Parasitology, School of Medicine and Nursing, Universidad del Pa\u00eds Vasco (UPV\/EHU), 48940 Bilbao, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3112-6947","authenticated-orcid":false,"given":"Piet W. J.","family":"de Groot","sequence":"additional","affiliation":[{"name":"Regional Center for Biomedical Research, Castilla-La Mancha Science &amp; Technology Park, University of Castilla\u2013La Mancha, 02008 Albacete, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1534-440X","authenticated-orcid":false,"given":"Oliver","family":"Bader","sequence":"additional","affiliation":[{"name":"Institute for Medical Microbiology, University Medical Center G\u00f6ttingen, Kreuzbergring 57, 37075 G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,1,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1093\/clinids\/14.3.756","article-title":"Candida parapsilosis: Epidemiology, pathogenicity, clinical manifestations, and antimicrobial susceptibility","volume":"14","author":"Weems","year":"1992","journal-title":"Clin. Infect. 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