{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:25:15Z","timestamp":1790364315894,"version":"4.1.0"},"reference-count":207,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T00:00:00Z","timestamp":1612224000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005668","name":"Funda\u00e7\u00e3o de Apoio \u00e0 Pesquisa do Distrito Federal","doi-asserted-by":"publisher","award":["193.001.533\/2016 \u2013 PRONEX\/CNPq"],"award-info":[{"award-number":["193.001.533\/2016 \u2013 PRONEX\/CNPq"]}],"id":[{"id":"10.13039\/501100005668","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>Paracoccidioidomycosis (PCM) is a notable fungal infection restricted to Latin America. Since the first description of the disease by Lutz up to the present day, Brazilian researchers have contributed to the understanding of the life cycle of this pathogen and provided the possibility of new targets for antifungal therapy based on the structural and functional genomics of Paracoccidioides. In this context, in silico approaches have selected molecules that act on specific targets, such as the thioredoxin system, with promising antifungal activity against Paracoccidioides. Some of these are already in advanced development stages. In addition, the application of nanostructured systems has addressed issues related to the high toxicity of conventional PCM therapy. Thus, the contribution of molecular biology and biotechnology to the advances achieved is unquestionable. However, it is still necessary to transcend the boundaries of synthetic chemistry, pharmaco-technics, and pharmacodynamics, aiming to turn promising molecules into newly available drugs for the treatment of fungal diseases.<\/jats:p>","DOI":"10.3390\/jof7020106","type":"journal-article","created":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T13:01:12Z","timestamp":1612270872000},"page":"106","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["One Century of Study: What We Learned about Paracoccidioides and How This Pathogen Contributed to Advances in Antifungal Therapy"],"prefix":"10.3390","volume":"7","author":[{"given":"Erika","family":"Seki Kioshima","sequence":"first","affiliation":[{"name":"Program in Biosciences and Pathophysiology, Department of Clinical Analysis and Biomedicine, State University of Maringa (UEM), Maringa, Parana 87020-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia","family":"de Souza Bonfim de Mendon\u00e7a","sequence":"additional","affiliation":[{"name":"Program in Biosciences and Pathophysiology, Department of Clinical Analysis and Biomedicine, State University of Maringa (UEM), Maringa, Parana 87020-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1763-3464","authenticated-orcid":false,"given":"Marcus","family":"de Melo Teixeira","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Bras\u00edlia (UnB), Brasilia, Distrito Federal 70910-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isis Regina","family":"Grenier Capoci","sequence":"additional","affiliation":[{"name":"Program in Biosciences and Pathophysiology, Department of Clinical Analysis and Biomedicine, State University of Maringa (UEM), Maringa, Parana 87020-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9516-8970","authenticated-orcid":false,"given":"Andr\u00e9","family":"Amaral","sequence":"additional","affiliation":[{"name":"Institute of Tropical Pathology and Public Health, Federal University of Goi\u00e1s, Goi\u00e2nia 74690-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franciele Abigail","family":"Vilugron Rodrigues-Vendramini","sequence":"additional","affiliation":[{"name":"Program in Biosciences and Pathophysiology, Department of Clinical Analysis and Biomedicine, State University of Maringa (UEM), Maringa, Parana 87020-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruna","family":"Lauton Sim\u00f5es","sequence":"additional","affiliation":[{"name":"Program in Biosciences and Pathophysiology, Department of Clinical Analysis and Biomedicine, State University of Maringa (UEM), Maringa, Parana 87020-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Karina","family":"Rodrigues Abadio","sequence":"additional","affiliation":[{"name":"Faculty of Agricultural Social Sciences, Mato Grosso State University, Nova Mutum, Mato Grosso 78450-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa","family":"Fernandes Matos","sequence":"additional","affiliation":[{"name":"Faculty of Ceilandia, University of Bras\u00edlia (UnB), Bras\u00edlia, Distrito Federal 72220-275, Brazil"},{"name":"Program in Microbial Biology, Institute of Biological Sciences, University of Bras\u00edlia, Bras\u00edlia 70910-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Sueli","family":"Soares Felipe","sequence":"additional","affiliation":[{"name":"Program of Genomic Sciences and Biotechnology, Catholic University of Brasilia, Bras\u00edlia 70790-160, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,2,2]]},"reference":[{"key":"ref_1","first-page":"121","article-title":"A pseudococcidic mycosis localized in the mouth and observed in Brazil. 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