{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T07:55:53Z","timestamp":1789631753949,"version":"build-2803163510"},"reference-count":31,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2021,4,18]],"date-time":"2021-04-18T00:00:00Z","timestamp":1618704000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ristekdikti Indonesia","award":["NKB-282\/UN2.RST\/HKP.05.00\/2020"],"award-info":[{"award-number":["NKB-282\/UN2.RST\/HKP.05.00\/2020"]}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/S019898\/1"],"award-info":[{"award-number":["MR\/S019898\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>The detection of Aspergillus antibody has a key role in the diagnosis of chronic pulmonary aspergillosis. Western blot (WB) and immunochromatography (ICT) lateral flow detection of Aspergillus antibody can be used as confirmatory and screening assays but their comparative performance in TB patients is not known. This study investigated the performance of these assays among 88 post-tuberculosis patients with suspected CPA. Sensitivity, specificity, receiver operating curve (ROC), area under-curve (AUC) and the agreement between two assays were evaluated. Both WB and ICT showed good sensitivity (80% and 85%, respectively) for detection of Aspergillus antibodies. Substantial agreement (0.716) between these assays was also obtained. The highest AUC result (0.804) was achieved with the combination of WB and ICT. The global intensity of WB correlated with the severity of symptoms in CPA group (p = 0.001). The combination of WB and ICT may increase specificity in CPA diagnosis.<\/jats:p>","DOI":"10.3390\/jof7040311","type":"journal-article","created":{"date-parts":[[2021,4,18]],"date-time":"2021-04-18T22:15:13Z","timestamp":1618784113000},"page":"311","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Performance of LDBio Aspergillus WB and ICT Antibody Detection in Chronic Pulmonary Aspergillosis"],"prefix":"10.3390","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3573-6312","authenticated-orcid":false,"given":"Anna","family":"Rozaliyani","sequence":"first","affiliation":[{"name":"Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta 10430, Indonesia"},{"name":"Pulmonary Mycosis Centre, Jakarta 10430, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Findra","family":"Setianingrum","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta 10430, Indonesia"},{"name":"Pulmonary Mycosis Centre, Jakarta 10430, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8228-7193","authenticated-orcid":false,"given":"Sresta","family":"Azahra","sequence":"additional","affiliation":[{"name":"Magister Program of Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta 10430, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asriyani","family":"Abdullah","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta 10430, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayu Eka","family":"Fatril","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta 10430, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harmi","family":"Rosianawati","sequence":"additional","affiliation":[{"name":"Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta 13230, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erlina","family":"Burhan","sequence":"additional","affiliation":[{"name":"Pulmonary Mycosis Centre, Jakarta 10430, Indonesia"},{"name":"Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta 13230, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diah","family":"Handayani","sequence":"additional","affiliation":[{"name":"Pulmonary Mycosis Centre, Jakarta 10430, Indonesia"},{"name":"Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta 13230, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arief Riadi","family":"Arifin","sequence":"additional","affiliation":[{"name":"Pulmonary Mycosis Centre, Jakarta 10430, Indonesia"},{"name":"MH Thamrin Hospital, Jakarta 10440, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamal","family":"Zaini","sequence":"additional","affiliation":[{"name":"Pulmonary Mycosis Centre, Jakarta 10430, Indonesia"},{"name":"Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta 13230, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mulyati","family":"Tugiran","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta 10430, Indonesia"},{"name":"Pulmonary Mycosis Centre, Jakarta 10430, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4987-4839","authenticated-orcid":false,"given":"Robiatul","family":"Adawiyah","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta 10430, Indonesia"},{"name":"Pulmonary Mycosis Centre, Jakarta 10430, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ridhawati","family":"Syam","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta 10430, Indonesia"},{"name":"Pulmonary Mycosis Centre, Jakarta 10430, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2818-4553","authenticated-orcid":false,"given":"Heri","family":"Wibowo","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta 10430, Indonesia"},{"name":"Pulmonary Mycosis Centre, Jakarta 10430, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Retno","family":"Wahyuningsih","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta 10430, Indonesia"},{"name":"Pulmonary Mycosis Centre, Jakarta 10430, Indonesia"},{"name":"Department of Parasitology, Faculty of Medicine, Universitas Kristen, Jakarta 13530, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0662-1265","authenticated-orcid":false,"given":"Chris","family":"Kosmidis","sequence":"additional","affiliation":[{"name":"Manchester Academic Health Science Centre, Division of Infection, Immunity and Respiratory Medicine, Faculty of Biology, School of Biological Sciences, Medicine and Health, University of Manchester, Manchester M23 9LT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5626-2251","authenticated-orcid":false,"given":"David W","family":"Denning","sequence":"additional","affiliation":[{"name":"Manchester Academic Health Science Centre, Division of Infection, Immunity and Respiratory Medicine, Faculty of Biology, School of Biological Sciences, Medicine and Health, University of Manchester, Manchester M23 9LT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,4,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"864","DOI":"10.2471\/BLT.11.089441","article-title":"Global Burden of Chronic Pulmonary Aspergillosis as a Sequel to Pulmonary Tuberculosis","volume":"89","author":"Denning","year":"2011","journal-title":"Bull. 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