{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T08:57:02Z","timestamp":1764061022537,"version":"build-2065373602"},"reference-count":53,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2021,4,30]],"date-time":"2021-04-30T00:00:00Z","timestamp":1619740800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>The emergence of azole resistant Aspergillus spp., especially Aspergillus fumigatus, has been described in several countries around the world with varying prevalence depending on the country. To our knowledge, azole resistance in Aspergillus spp. has not been reported in the West Indies yet. In this study, we investigated the antifungal susceptibility of clinical and environmental isolates of Aspergillus spp. from Martinique, and the potential resistance mechanisms associated with mutations in cyp51A gene. Overall, 208 Aspergillus isolates were recovered from clinical samples (n = 45) and environmental soil samples (n = 163). They were screened for resistance to azole drugs using selective culture media. The Minimum Inhibitory Concentrations (MIC) towards voriconazole, itraconazole, posaconazole and isavuconazole, as shown by the resistant isolates, were determined using the European Committee on Antimicrobial Susceptibility Testing (EUCAST) microdilution broth method. Eight isolates (A. fumigatus, n = 6 and A. terreus, n = 2) had high MIC for at least one azole drug. The sequencing of cyp51A gene revealed the mutations G54R and TR34\/L98H in two A. fumigatus clinical isolates. Our study showed for the first time the presence of azole resistance in A. fumigatus and A. terreus isolates in the French West Indies.<\/jats:p>","DOI":"10.3390\/jof7050355","type":"journal-article","created":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T21:35:39Z","timestamp":1619904939000},"page":"355","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Azole Resistance in Clinical and Environmental Aspergillus Isolates from the French West Indies (Martinique)"],"prefix":"10.3390","volume":"7","author":[{"given":"Lorra","family":"Monpierre","sequence":"first","affiliation":[{"name":"Unit\u00e9 de Parasitologie-Mycologie, D\u00e9partement Pr\u00e9vention, Diagnostic, Traitement des infections, CHU Henri Mondor, Assistance Publique des H\u00f4pitaux de Paris (AP-HP), 94140 Cr\u00e9teil, France"},{"name":"EA DYNAMiC 7380, Facult\u00e9 de Sant\u00e9, Univ Paris-Est Cr\u00e9teil (UPEC), Cr\u00e9teil, France-\u00c9cole Nationale V\u00e9t\u00e9rinaire d\u2019Alfort (ENVA), USC Anses, 94700 Maison-Alfort, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Desbois-Nogard","sequence":"additional","affiliation":[{"name":"Laboratoire de Parasitologie-Mycologie H\u00f4pital Pierre Zobda-Quitman, CHU de la Martinique, 97261 Fort-de-France, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Valsecchi","sequence":"additional","affiliation":[{"name":"EA DYNAMiC 7380, Facult\u00e9 de Sant\u00e9, Univ Paris-Est Cr\u00e9teil (UPEC), Cr\u00e9teil, France-\u00c9cole Nationale V\u00e9t\u00e9rinaire d\u2019Alfort (ENVA), USC Anses, 94700 Maison-Alfort, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marielle","family":"Bajal","sequence":"additional","affiliation":[{"name":"Laboratoire de Parasitologie-Mycologie H\u00f4pital Pierre Zobda-Quitman, CHU de la Martinique, 97261 Fort-de-France, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9cile","family":"Angebault","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Parasitologie-Mycologie, D\u00e9partement Pr\u00e9vention, Diagnostic, Traitement des infections, CHU Henri Mondor, Assistance Publique des H\u00f4pitaux de Paris (AP-HP), 94140 Cr\u00e9teil, France"},{"name":"EA DYNAMiC 7380, Facult\u00e9 de Sant\u00e9, Univ Paris-Est Cr\u00e9teil (UPEC), Cr\u00e9teil, France-\u00c9cole Nationale V\u00e9t\u00e9rinaire d\u2019Alfort (ENVA), USC Anses, 94700 Maison-Alfort, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1720-7310","authenticated-orcid":false,"given":"Charline","family":"Miossec","sequence":"additional","affiliation":[{"name":"Laboratoire de Parasitologie-Mycologie H\u00f4pital Pierre Zobda-Quitman, CHU de la Martinique, 97261 Fort-de-France, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3028-2665","authenticated-orcid":false,"given":"Fran\u00e7oise","family":"Botterel","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Parasitologie-Mycologie, D\u00e9partement Pr\u00e9vention, Diagnostic, Traitement des infections, CHU Henri Mondor, Assistance Publique des H\u00f4pitaux de Paris (AP-HP), 94140 Cr\u00e9teil, France"},{"name":"EA DYNAMiC 7380, Facult\u00e9 de Sant\u00e9, Univ Paris-Est Cr\u00e9teil (UPEC), Cr\u00e9teil, France-\u00c9cole Nationale V\u00e9t\u00e9rinaire d\u2019Alfort (ENVA), USC Anses, 94700 Maison-Alfort, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2817-3830","authenticated-orcid":false,"given":"\u00c9ric","family":"Dannaoui","sequence":"additional","affiliation":[{"name":"EA DYNAMiC 7380, Facult\u00e9 de Sant\u00e9, Univ Paris-Est Cr\u00e9teil (UPEC), Cr\u00e9teil, France-\u00c9cole Nationale V\u00e9t\u00e9rinaire d\u2019Alfort (ENVA), USC Anses, 94700 Maison-Alfort, France"},{"name":"Unit\u00e9 de Parasitologie-Mycologie, Service de Microbiologie, H\u00f4pital Europ\u00e9en Georges Pompidou, AP-HP, 75015 Paris, France"},{"name":"Universit\u00e9 de Paris, 75006 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,4,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1128\/AAC.41.6.1364","article-title":"Itraconazole resistance in Aspergillus fumigatus","volume":"41","author":"Denning","year":"1997","journal-title":"Antimicrob. 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