{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T05:30:23Z","timestamp":1790314223269,"version":"4.1.0"},"reference-count":83,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T00:00:00Z","timestamp":1620172800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>Fungi from the genus Candida are very important human and animal pathogens. Many strains can produce biofilms, which inhibit the activity of antifungal drugs and increase the tolerance or resistance to them as well. Clinically, this process leads to persistent infections and increased mortality. Today, many Candida species are resistant to drugs, including C. auris, which is a multiresistant pathogen. Natural compounds may potentially be used to combat multiresistant and biofilm-forming strains. The aim of this review was to present plant-derived preparations and compounds that inhibit Candida biofilm formation by at least 50%. A total of 29 essential oils and 16 plant extracts demonstrate activity against Candida biofilms, with the following families predominating: Lamiaceae, Myrtaceae, Asteraceae, Fabaceae, and Apiacae. Lavandula dentata (0.045\u20130.07 mg\/L), Satureja macrosiphon (0.06\u20138 mg\/L), and Ziziphora tenuior (2.5 mg\/L) have the best antifungal activity. High efficacy has also been observed with Artemisia judaica, Lawsonia inermis, and Thymus vulgaris. Moreover, 69 plant compounds demonstrate activity against Candida biofilms. Activity in concentrations below 16 mg\/L was observed with phenolic compounds (thymol, pterostilbene, and eugenol), sesquiterpene derivatives (warburganal, polygodial, and ivalin), chalconoid (lichochalcone A), steroidal saponin (dioscin), flavonoid (baicalein), alkaloids (waltheriones), macrocyclic bisbibenzyl (riccardin D), and cannabinoid (cannabidiol). The above compounds act on biofilm formation and\/or mature biofilms. In summary, plant preparations and compounds exhibit anti-biofilm activity against Candida. Given this, they may be a promising alternative to antifungal drugs.<\/jats:p>","DOI":"10.3390\/jof7050360","type":"journal-article","created":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T11:06:01Z","timestamp":1620212761000},"page":"360","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Plant Preparations and Compounds with Activities against Biofilms Formed by Candida spp."],"prefix":"10.3390","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6599-9204","authenticated-orcid":false,"given":"Tomasz M.","family":"Karpi\u0144ski","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology, Pozna\u0144 University of Medical Sciences, Wieniawskiego 3, 61-712 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2305-3116","authenticated-orcid":false,"given":"Marcin","family":"O\u017carowski","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Institute of Natural Fibres and Medicinal Plants, National Research Institute, Wojska Polskiego 71b, 60-630 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Seremak-Mrozikiewicz","sequence":"additional","affiliation":[{"name":"Division of Perinatology and Women\u2019s Diseases, Pozna\u0144 University of Medical Sciences, Polna 33, 60-535 Pozna\u0144, Poland"},{"name":"Laboratory of Molecular Biology in Division of Perinatology and Women\u2019s Diseases, Pozna\u0144 University of Medical Sciences, Polna 33, 60-535 Pozna\u0144, Poland"},{"name":"Department of Pharmacology and Phytochemistry, Institute of Natural Fibres and Medicinal Plants, National Research Institute, Kolejowa 2, 62-064 Plewiska, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubert","family":"Wolski","sequence":"additional","affiliation":[{"name":"Division of Perinatology and Women\u2019s Diseases, Pozna\u0144 University of Medical Sciences, Polna 33, 60-535 Pozna\u0144, Poland"},{"name":"Division of Gynecology and Obstetrics, Podhale Multidisciplinary Hospital, Szpitalna 14, 34-400 Nowy Targ, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1738-953X","authenticated-orcid":false,"given":"Artur","family":"Adamczak","sequence":"additional","affiliation":[{"name":"Department of Botany, Breeding and Agricultural Technology of Medicinal Plants, Institute of Natural Fibres and Medicinal Plants, National Research Institute, Kolejowa 2, 62-064 Plewiska, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"165rv13","DOI":"10.1126\/scitranslmed.3004404","article-title":"Hidden Killers: Human Fungal Infections","volume":"4","author":"Brown","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Ciurea, C.N., Kosovski, I.-B., Mare, A.D., Toma, F., Pintea-Simon, I.A., and Man, A. (2020). Candida and Candidiasis-Opportunism Versus Pathogenicity: A Review of the Virulence Traits. Microorganisms, 8.","DOI":"10.3390\/microorganisms8060857"},{"key":"ref_3","unstructured":"Moran, G., Coleman, D., and Sullivan, D. (2012). An Introduction to the Medically Important Candida Species. Candida and Candidiasis, Wiley. [2nd ed.]."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Buranarom, N., Komin, O., and Matangkasombut, O. (2020). Hyposalivation, Oral Health, and Candida Colonization in Independent Dentate Elders. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0242832"},{"key":"ref_5","unstructured":"Arya, N.R., and Naureen, R.B. (2021). Candidiasis. StatPearls, StatPearls Publishing."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"555363","DOI":"10.3389\/fimmu.2020.555363","article-title":"Mucosal IgA Prevents Commensal Candida Albicans Dysbiosis in the Oral Cavity","volume":"11","author":"Millet","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1016\/S0140-6736(07)60917-9","article-title":"Vulvovaginal Candidosis","volume":"369","author":"Sobel","year":"2007","journal-title":"Lancet"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Vila, T., Sultan, A.S., Montelongo-Jauregui, D., and Jabra-Rizk, M.A. (2020). Oral Candidiasis: A Disease of Opportunity. J. Fungi, 6.","DOI":"10.3390\/jof6010015"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"88","DOI":"10.5114\/lr.2020.99067","article-title":"The Antimicrobial Effectiveness of Antiseptics as a Challenge in Hard to Heal Wounds","volume":"17","author":"Sopata","year":"2020","journal-title":"Leczenie Ran"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Bhattacharya, S., Sae-Tia, S., and Fries, B.C. (2020). Candidiasis and Mechanisms of Antifungal Resistance. Antibiotics, 9.","DOI":"10.3390\/antibiotics9060312"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/1469-0691.12039","article-title":"ESCMID* Guideline for the Diagnosis and Management of Candida Diseases 2012: Non-Neutropenic Adult Patients","volume":"18","author":"Cornely","year":"2012","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1093\/cid\/civ933","article-title":"Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of America","volume":"62","author":"Pappas","year":"2016","journal-title":"Clin. Infect. Dis."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"7495218","DOI":"10.1155\/2018\/7495218","article-title":"Antifungal Susceptibility and Biofilm Production of Candida Spp. Isolated from Clinical Samples","volume":"2018","author":"Marak","year":"2018","journal-title":"Int. J. Microbiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1093\/jac\/dkx034","article-title":"Candida auris Candidaemia in Indian ICUs: Analysis of Risk Factors","volume":"72","author":"Rudramurthy","year":"2017","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"119","DOI":"10.4161\/viru.22913","article-title":"Candida Albicans Pathogenicity Mechanisms","volume":"4","author":"Mayer","year":"2013","journal-title":"Virulence"},{"key":"ref_16","first-page":"93","article-title":"Antifungal Activity of the Rhizome Extracts of Pulsatilla Vulgaris against Candida Glabrata","volume":"9","author":"Sienkiewicz","year":"2019","journal-title":"Eur. J. Biol. Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e02192","DOI":"10.1016\/j.heliyon.2019.e02192","article-title":"Challenges of Intervention, Treatment, and Antibiotic Resistance of Biofilm-Forming Microorganisms","volume":"5","author":"Gebreyohannes","year":"2019","journal-title":"Heliyon"},{"key":"ref_18","unstructured":"Pereira, R., Dos Santos Fontenelle, R.O., de Brito, E.H.S., and de Morais, S.M. (2020). Biofilm of Candida Albicans: Formation, Regulation and Resistance. J. Appl. Microbiol."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Tumbarello, M., Fiori, B., Trecarichi, E.M., Posteraro, P., Losito, A.R., De Luca, A., Sanguinetti, M., Fadda, G., Cauda, R., and Posteraro, B. (2012). Risk Factors and Outcomes of Candidemia Caused by Biofilm-Forming Isolates in a Tertiary Care Hospital. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0033705"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Karpi\u0144ski, T.M. (2020). Essential Oils of Lamiaceae Family Plants as Antifungals. Biomolecules, 10.","DOI":"10.3390\/biom10010103"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1055\/a-1201-3375","article-title":"Chemical Characterization of Lavandula Dentata Essential Oil Cultivated in Chile and Its Antibiofilm Effect against Candida Albicans","volume":"86","author":"Chevecich","year":"2020","journal-title":"Planta Med."},{"key":"ref_22","first-page":"20","article-title":"Chemical Compositions and Antifungal Activities of Satureja Macrosiphon against Candida and Aspergillus Species","volume":"5","author":"Motamedi","year":"2019","journal-title":"Curr. Med. Mycol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.jep.2016.10.076","article-title":"Ziziphora Tenuior, L. Essential Oil from Dana Biosphere Reserve (Southern Jordan); Chemical Characterization and Assessment of Biological Activities","volume":"194","author":"Cabral","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.jep.2016.06.023","article-title":"Chemical Composition and Biological Activities of Artemisia Judaica Essential Oil from Southern Desert of Jordan","volume":"191","author":"Cabral","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Soliman, S.S.M., Semreen, M.H., El-Keblawy, A.A., Abdullah, A., Uppuluri, P., and Ibrahim, A.S. (2017). Assessment of Herbal Drugs for Promising Anti-Candida Activity. BMC Complement. Altern. Med., 17.","DOI":"10.1186\/s12906-017-1760-x"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"100911","DOI":"10.1016\/j.mycmed.2019.100911","article-title":"Thymus Vulgaris Essential Oil and Thymol Inhibit Biofilms and Interact Synergistically with Antifungal Drugs against Drug Resistant Strains of Candida Albicans and Candida Tropicalis","volume":"30","author":"Jafri","year":"2020","journal-title":"J. Mycol. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"113119","DOI":"10.1016\/j.jep.2020.113119","article-title":"Bioguided Isolation, Identification and Activity Evaluation of Antifungal Compounds from Acorus Tatarinowii Schott","volume":"261","author":"Wang","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"3615","DOI":"10.1038\/s41598-020-60178-0","article-title":"Garlic Alters the Expression of Putative Virulence Factor Genes SIR2 and ECE1 in Vulvovaginal C. Albicans Isolates","volume":"10","author":"Said","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Bersan, S.M.F., Galv\u00e3o, L.C.C., Goes, V.F.F., Sartoratto, A., Figueira, G.M., Rehder, V.L.G., Alencar, S.M., Duarte, R.M.T., Rosalen, P.L., and Duarte, M.C.T. (2014). Action of Essential Oils from Brazilian Native and Exotic Medicinal Species on Oral Biofilms. BMC Complement. Altern. Med., 14.","DOI":"10.1186\/1472-6882-14-451"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"647","DOI":"10.3389\/fmicb.2018.00647","article-title":"Effects of Acetone Fraction From Buchenavia Tomentosa Aqueous Extract and Gallic Acid on Candida Albicans Biofilms and Virulence Factors","volume":"9","author":"Teodoro","year":"2018","journal-title":"Front. Microbiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/jam.14783","article-title":"Antifungal Activity of Extracts and Purified Saponins from the Rhizomes of Chamaecostus Cuspidatus against Candida and Trichophyton Species","volume":"130","author":"Kohlhoff","year":"2021","journal-title":"J. Appl. Microbiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"e200349","DOI":"10.1590\/0074-02760200349","article-title":"Effect of Cinnamomum Verum Leaf Essential Oil on Virulence Factors of Candida Species and Determination of the In-Vivo Toxicity with Galleria Mellonella Model","volume":"115","author":"Wijesinghe","year":"2020","journal-title":"Mem. Inst. Oswaldo. Cruz."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Pedroso, R.D.S., Balbino, B.L., Andrade, G., Dias, M.C.P.S., Alvarenga, T.A., Pedroso, R.C.N., Pimenta, L.P., Lucarini, R., Pauletti, P.M., and Janu\u00e1rio, A.H. (2019). In Vitro and In Vivo Anti-Candida Spp. Activity of Plant-Derived Products. Plants, 8.","DOI":"10.3390\/plants8110494"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Andrade, G., Orlando, H.C.S., Scorzoni, L., Pedroso, R.S., Abr\u00e3o, F., Carvalho, M.T.M., Veneziani, R.C.S., Ambr\u00f3sio, S.R., Bastos, J.K., and Mendes-Giannini, M.J.S. (2020). Brazilian Copaifera Species: Antifungal Activity against Clinically Relevant Candida Species, Cellular Target, and In Vivo Toxicity. J. Fungi, 6.","DOI":"10.3390\/jof6030153"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"e99086","DOI":"10.1371\/journal.pone.0099086","article-title":"Coriandrum Sativum L. (Coriander) Essential Oil: Antifungal Activity and Mode of Action on Candida spp., and Molecular Targets Affected in Human Whole-Genome Expression","volume":"9","author":"Murata","year":"2014","journal-title":"PLoS ONE"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1080\/08927014.2017.1280731","article-title":"Inhibitory Effects of the Essential Oils \u03b1-Longipinene and Linalool on Biofilm Formation and Hyphal Growth of Candida Albicans","volume":"33","author":"Manoharan","year":"2017","journal-title":"Biofouling"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.jep.2012.01.045","article-title":"Biofilm Inhibition by Cymbopogon Citratus and Syzygium Aromaticum Essential Oils in the Strains of Candida Albicans","volume":"140","author":"Khan","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s11046-007-9077-9","article-title":"Prevention of Candida Albicans Biofilm by Plant Oils","volume":"165","author":"Agarwal","year":"2008","journal-title":"Mycopathologia"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"De Toledo, L.G., Ramos, M.A.D.S., Sp\u00f3sito, L., Castilho, E.M., Pavan, F.R., Lopes, \u00c9.D.O., Zocolo, G.J., Silva, F.A.N., Soares, T.H., and Dos Santos, A.G. (2016). Essential Oil of Cymbopogon Nardus (L.) Rendle: A Strategy to Combat Fungal Infections Caused by Candida Species. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17081252"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1093\/jac\/dkp362","article-title":"Antimicrobial Efficacy of Eucalyptus Oil and 1,8-Cineole Alone and in Combination with Chlorhexidine Digluconate against Microorganisms Grown in Planktonic and Biofilm Cultures","volume":"64","author":"Hendry","year":"2009","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.micpath.2017.09.062","article-title":"Antimicrobial and Antibiofilm Activities of Nanoemulsions Containing Eucalyptus Globulus Oil against Pseudomonas Aeruginosa and Candida spp.","volume":"112","author":"Quatrin","year":"2017","journal-title":"Microb. Pathog."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.micpath.2017.02.044","article-title":"Unexplored Endemic Fruit Species from Brazil: Antibiofilm Properties, Insights into Mode of Action, and Systemic Toxicity of Four Eugenia spp.","volume":"105","author":"Sardi","year":"2017","journal-title":"Microb. Pathog."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1039\/C5FO00066A","article-title":"Extracts of Three Laserpitium L. Species and Their Principal Components Laserpitine and Sesquiterpene Lactones Inhibit Microbial Growth and Biofilm Formation by Oral Candida Isolates","volume":"6","author":"Heyerick","year":"2015","journal-title":"Food. Funct."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Benzaid, C., Belmadani, A., Djeribi, R., and Rouabhia, M. (2019). The Effects of Mentha \u00d7 Piperita Essential Oil on C. Albicans Growth, Transition, Biofilm Formation, and the Expression of Secreted Aspartyl Proteinases Genes. Antibiotics, 8.","DOI":"10.3390\/antibiotics8010010"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1080\/14786419.2014.925892","article-title":"Antifungal, Anti-Biofilm and Adhesion Activity of the Essential Oil of Myrtus Communis L. against Candida Species","volume":"28","author":"Cannas","year":"2014","journal-title":"Nat. Prod. Res."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Stojkovi\u0107, D., Dias, M.I., Drakuli\u0107, D., Barros, L., Stevanovi\u0107, M., C F R Ferreira, I., and D Sokovi\u0107, M. (2020). Methanolic Extract of the Herb Ononis Spinosa L. Is an Antifungal Agent with No Cytotoxicity to Primary Human Cells. Pharmaceuticals, 13.","DOI":"10.3390\/ph13040078"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1093\/mmy\/myw003","article-title":"Antifungal Activity of Plant-Derived Essential Oils on Candida Tropicalis Planktonic and Biofilms Cells","volume":"54","author":"Souza","year":"2016","journal-title":"Med. Mycol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1099\/jmm.0.063834-0","article-title":"A Novel Nerolidol-Rich Essential Oil from Piper Claussenianum Modulates Candida Albicans Biofilm","volume":"63","author":"Curvelo","year":"2014","journal-title":"J. Med. Microbiol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1080\/08927014.2013.820825","article-title":"The Anti-Biofilm Potential of Pomegranate (Punica Granatum L.) Extract against Human Bacterial and Fungal Pathogens","volume":"29","author":"Bakkiyaraj","year":"2013","journal-title":"Biofouling"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"112120","DOI":"10.1016\/j.jep.2019.112120","article-title":"Unveiling the Bioactive Potential of the Essential Oil of a Portuguese Endemism, Santolina Impressa","volume":"244","author":"Zuzarte","year":"2019","journal-title":"J. Ethnopharmacol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.micpath.2016.04.014","article-title":"Chemical Composition and Antifungal Activity of Satureja Hortensis L. Essentiall Oil against Planktonic and Biofilm Growth of Candida Albicans Isolates from Buccal Lesions of HIV(+) Individuals","volume":"96","author":"Sharifzadeh","year":"2016","journal-title":"Microb. Pathog."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"112352","DOI":"10.1016\/j.jep.2019.112352","article-title":"Biofilm Inhibiting Properties of Compounds from the Leaves of Warburgia Ugandensis Sprague Subsp. Ugandensis against Candida and Staphylococcal Biofilms","volume":"248","author":"Kipanga","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"ref_53","first-page":"933","article-title":"The Effect of Zuccagnia Punctata, an Argentine Medicinal Plant, on Virulence Factors from Candida Species","volume":"9","author":"Gabriela","year":"2014","journal-title":"Nat. Prod. Commun."},{"key":"ref_54","first-page":"135","article-title":"Efficacy of Octenidine against Pseudomonas Aeruginosa Strains","volume":"9","year":"2019","journal-title":"Eur. J. Biol. Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"e1543","DOI":"10.21769\/BioProtoc.1543","article-title":"XTT Assay of Antifungal Activity","volume":"5","author":"Loures","year":"2015","journal-title":"Bio. Protoc."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1080\/14786410701482244","article-title":"Composition and Antifungal Activity of the Essential Oil of Mentha Cervina from Portugal","volume":"21","author":"Vicente","year":"2007","journal-title":"Nat. Prod. Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1002\/jsfa.5967","article-title":"Volatile Constituents, Phenolic Compounds, and Antioxidant Activity of Calamintha Glandulosa (Req.) Bentham","volume":"93","author":"Vidic","year":"2013","journal-title":"J. Sci. Food Agric."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1093\/jac\/dkr512","article-title":"Antibiofilm Activity of Certain Phytocompounds and Their Synergy with Fluconazole against Candida Albicans Biofilms","volume":"67","author":"Khan","year":"2012","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_59","first-page":"1032","article-title":"Candida Albicans Biofilm Inhibition by Synergistic Action of Terpenes and Fluconazole","volume":"51","author":"Pemmaraju","year":"2013","journal-title":"Indian J. Exp. Biol."},{"key":"ref_60","unstructured":"(2021, March 19). EUCAST: Breakpoints for Antifungals. Available online: https:\/\/eucast.org\/astoffungi\/clinicalbreakpointsforantifungals\/."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"e801","DOI":"10.1111\/j.1439-0507.2011.02028.x","article-title":"Effect of Licorice Compounds Licochalcone A, Glabridin and Glycyrrhizic Acid on Growth and Virulence Properties of Candida Albicans","volume":"54","author":"Messier","year":"2011","journal-title":"Mycoses"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.ijantimicag.2008.01.026","article-title":"In Vitro Activity of Baicalein against Candida Albicans Biofilms","volume":"32","author":"Cao","year":"2008","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1021\/acs.jnatprod.5b00896","article-title":"Antifungal Quinoline Alkaloids from Waltheria Indica","volume":"79","author":"Cretton","year":"2016","journal-title":"J. Nat. Prod."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1248\/bpb.32.1417","article-title":"The Inhibitory Effect of a Macrocyclic Bisbibenzyl Riccardin D on the Biofilms of Candida Albicans","volume":"32","author":"Cheng","year":"2009","journal-title":"Biol. Pharm. Bull."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Hu, D.-D., Zhang, R.-L., Zou, Y., Zhong, H., Zhang, E.-S., Luo, X., Wang, Y., and Jiang, Y.-Y. (2017). The Structure-Activity Relationship of Pterostilbene Against Candida Albicans Biofilms. Molecules, 22.","DOI":"10.3390\/molecules22030360"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Feldman, M., Sionov, R.V., Mechoulam, R., and Steinberg, D. (2021). Anti-Biofilm Activity of Cannabidiol against Candida Albicans. Microorganisms, 9.","DOI":"10.3390\/microorganisms9020441"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"5409","DOI":"10.1016\/j.bmcl.2015.09.013","article-title":"Sesquiterpenes from Carpesium Macrocephalum Inhibit Candida Albicans Biofilm Formation and Dimorphism","volume":"25","author":"Xie","year":"2015","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.4014\/jmb.1402.02056","article-title":"Phenylpropanoids of Plant Origin as Inhibitors of Biofilm Formation by Candida Albicans","volume":"24","author":"Raut","year":"2014","journal-title":"J. Microbiol. Biotechnol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1080\/08927014.2012.749398","article-title":"Terpenoids of Plant Origin Inhibit Morphogenesis, Adhesion, and Biofilm Formation by Candida Albicans","volume":"29","author":"Raut","year":"2013","journal-title":"Biofouling"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Ivanov, M., Kannan, A., Stojkovi\u0107, D.S., Glamo\u010dlija, J., Calhelha, R.C., Ferreira, I.C.F.R., Sanglard, D., and Sokovi\u0107, M. (2021). Camphor and Eucalyptol-Anticandidal Spectrum, Antivirulence Effect, Efflux Pumps Interference and Cytotoxicity. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22020483"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.ijantimicag.2008.01.028","article-title":"In Vitro Activity of Terpenes against Candida Biofilms","volume":"31","author":"Dalleau","year":"2008","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Touil, H.F.Z., Boucherit, K., Boucherit-Otmani, Z., Khoder, G., Madkour, M., and Soliman, S.S.M. (2020). Optimum Inhibition of Amphotericin-B-Resistant Candida Albicans Strain in Single- and Mixed-Species Biofilms by Candida and Non-Candida Terpenoids. Biomolecules, 10.","DOI":"10.3390\/biom10020342"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/yea.3230","article-title":"Emodin, a Natural Inhibitor of Protein Kinase CK2, Suppresses Growth, Hyphal Development, and Biofilm Formation of Candida Albicans","volume":"34","author":"Janeczko","year":"2017","journal-title":"Yeast"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1476-0711-9-7","article-title":"In Vitro Antifungal Activity of Hydroxychavicol Isolated from Piper Betle L.","volume":"9","author":"Ali","year":"2010","journal-title":"Ann. Clin. Microbiol. Antimicrob."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"561298","DOI":"10.3389\/fmicb.2020.561298","article-title":"Inhibitory Effect of Morin Against Candida Albicans Pathogenicity and Virulence Factor Production: An in Vitro and in Vivo Approaches","volume":"11","author":"Abirami","year":"2020","journal-title":"Front. Microbiol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"6305","DOI":"10.3390\/molecules17066305","article-title":"Biological Activities of \u03b1-Pinene and \u03b2-Pinene Enantiomers","volume":"17","author":"Lopes","year":"2012","journal-title":"Molecules"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.3389\/fmicb.2020.01525","article-title":"Antifungal Activity of the Natural Coumarin Scopoletin Against Planktonic Cells and Biofilms From a Multidrug-Resistant Candida Tropicalis Strain","volume":"11","author":"Lemos","year":"2020","journal-title":"Front. Microbiol."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Kim, H.-R., and Eom, Y.-B. (2020). Antifungal and Anti-Biofilm Effects of 6-Shogaol against Candida Auris. J. Appl. Microbiol.","DOI":"10.1111\/jam.14870"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.phytochem.2018.08.003","article-title":"Phytochemistry of Compounds Isolated from the Leaf-Surface Extract of Psiadia Punctulata (DC.) Vatke Growing in Saudi Arabia","volume":"155","author":"Bader","year":"2018","journal-title":"Phytochemistry"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1007\/s12026-016-8785-y","article-title":"Thymol Has Antifungal Activity against Candida Albicans during Infection and Maintains the Innate Immune Response Required for Function of the P38 MAPK Signaling Pathway in Caenorhabditis Elegans","volume":"64","author":"Shu","year":"2016","journal-title":"Immunol. Res."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.ijantimicag.2007.12.013","article-title":"Thymol Inhibits Candida Albicans Biofilm Formation and Mature Biofilm","volume":"31","author":"Braga","year":"2008","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1016\/j.peptides.2011.06.020","article-title":"Identification of an Antifungal Peptide from Trapa Natans Fruits with Inhibitory Effects on Candida Tropicalis Biofilm Formation","volume":"32","author":"Mandal","year":"2011","journal-title":"Peptides"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"112965","DOI":"10.1016\/j.jep.2020.112965","article-title":"Dodonaea Viscosa Var Angustifolia Derived 5,6,8-Trihydroxy-7,4\u2019 Dimethoxy Flavone Inhibits Ergosterol Synthesis and the Production of Hyphae and Biofilm in Candida Albicans","volume":"259","author":"Patel","year":"2020","journal-title":"J. Ethnopharmacol."}],"container-title":["Journal of Fungi"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2309-608X\/7\/5\/360\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:57:15Z","timestamp":1760162235000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2309-608X\/7\/5\/360"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,5]]},"references-count":83,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2021,5]]}},"alternative-id":["jof7050360"],"URL":"https:\/\/doi.org\/10.3390\/jof7050360","relation":{},"ISSN":["2309-608X"],"issn-type":[{"value":"2309-608X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,5]]}}}