{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T19:46:59Z","timestamp":1780602419503,"version":"3.54.1"},"reference-count":20,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2021,7,23]],"date-time":"2021-07-23T00:00:00Z","timestamp":1626998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013699","name":"Bundesministerium f\u00fcr Bildung, Wissenschaft und Forschung","doi-asserted-by":"publisher","award":["Maputo Tuberculosis Trials Unit: MaTuTU- project\u201d- 01DG13013"],"award-info":[{"award-number":["Maputo Tuberculosis Trials Unit: MaTuTU- project\u201d- 01DG13013"]}],"id":[{"id":"10.13039\/501100013699","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>Background: Chronic pulmonary aspergillosis (CPA) is a life-threatening sequel in patients with pulmonary tuberculosis (PTB). Aspergillus-specific IgG antibody is a useful diagnostic biomarker supporting CPA diagnosis, especially in countries with limited health recourses. Methods: We conducted a prospective pilot study to assess the seroprevalence of Aspergillus-specific IgG antibodies among 61 Mozambican tuberculosis patients before, during, and after the end of TB treatment. Aspergillus-specific IgG antibody levels were measured using the ImmunoCAP\u00ae. Results: In this study, 3 out of 21 HIV-negative PTB patients had a positive Aspergillus-specific IgG antibody level before, during, and after the end of TB treatment. Antibody levels were 41.1, 45.5, and 174 mg\/L at end of treatment (EOT), respectively. Additionally, two HIV-negative PTB patients with negative Aspergillus-specific IgG antibody levels at baseline became seropositive at EOT (41.9 and 158 mg\/L, respectively). Interestingly, none of the HIV-positive PTB patients (40\/61) had a positive Aspergillus-specific IgG antibody level at any time, neither at baseline nor at EOT. Probable CPA was diagnosed in one HIV-negative patient (5%; 1\/20). Conclusion: Seroprevalence of Aspergillus-specific IgG antibody may differ between HIV-negative and HIV-positive Mozambican PTB patients. Future studies evaluating post-tuberculosis lung disease should integrate CPA as a life-threatening sequel to PTB.<\/jats:p>","DOI":"10.3390\/jof7080595","type":"journal-article","created":{"date-parts":[[2021,7,25]],"date-time":"2021-07-25T22:06:21Z","timestamp":1627250781000},"page":"595","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Seroprevalence of Aspergillus-Specific IgG Antibody among Mozambican Tuberculosis Patients"],"prefix":"10.3390","volume":"7","author":[{"given":"Helmut J. F.","family":"Salzer","sequence":"first","affiliation":[{"name":"Department of Pulmonary Medicine, Kepler University Hospital, 4021 Linz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Massango","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Sa\u00fade (INS), Marracuene 3934, Mozambique"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilesh","family":"Bhatt","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Sa\u00fade (INS), Marracuene 3934, Mozambique"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emelva","family":"Machonisse","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Sa\u00fade (INS), Marracuene 3934, Mozambique"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2385-2287","authenticated-orcid":false,"given":"Maja","family":"Reimann","sequence":"additional","affiliation":[{"name":"Division of Clinical Infectious Diseases, Research Center Borstel, 23845 Borstel, Germany"},{"name":"German Center for Infection Research (DZIF), Partner Site Hamburg-L\u00fcbeck-Borstel-Riems, 23845 Borstel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4600-7518","authenticated-orcid":false,"given":"Sven","family":"Heldt","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Kepler University Hospital, 4021 Linz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Lange","sequence":"additional","affiliation":[{"name":"Division of Clinical Infectious Diseases, Research Center Borstel, 23845 Borstel, Germany"},{"name":"German Center for Infection Research (DZIF), Partner Site Hamburg-L\u00fcbeck-Borstel-Riems, 23845 Borstel, Germany"},{"name":"Respiratory Medicine & International Health, University of L\u00fcbeck, 23563 Luebeck, Germany"},{"name":"Baylor College of Medicine and Texas Children\u2019s Hospital, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7642-1835","authenticated-orcid":false,"given":"Michael","family":"Hoelscher","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, 80802 Munich, Germany"},{"name":"German Center for Infection Research (DZIF), Partner Site Munich, 80802 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6701-4202","authenticated-orcid":false,"given":"Celso","family":"Khosa","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Sa\u00fade (INS), Marracuene 3934, Mozambique"},{"name":"Center for International Health-CIH LMU, 80802 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Rachow","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, 80802 Munich, Germany"},{"name":"German Center for Infection Research (DZIF), Partner Site Munich, 80802 Munich, Germany"},{"name":"Center for International Health-CIH LMU, 80802 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Maitre, T., Cottenet, J., Godet, C., Roussot, A., Abdoul Carime, N., Ok, V., Parrot, A., Bonniaud, P., Quantin, C., and Cadranel, J. 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