{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:25:53Z","timestamp":1789691153887,"version":"4.0.1"},"reference-count":55,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2021,9,25]],"date-time":"2021-09-25T00:00:00Z","timestamp":1632528000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>Invasive fungal disease (IFD) is a growing health burden. High mortality rates, increasing numbers of at-risk hosts, and a limited availability of rapid diagnostics and therapeutic options mean that patients are increasingly exposed to unnecessary antifungals. High rates of prescriptions promote patient exposure to undue toxicity and drive the emergence of resistance. Antifungal stewardship (AFS) aims to guide antifungal usage and reduce unnecessary exposure and antifungal consumption whilst maintaining or improving outcomes. Here, we examine several AFS approaches from hospitals across the UK and Ireland to demonstrate the benefits of AFS practices and support the broader implementation of AFS as both a necessary and achievable strategy. Since the accuracy and turnaround times (TATs) of diagnostic tools can impact treatment decisions, several AFS strategies have included the development and implementation of diagnostic-driven care pathways. AFS informed treatment strategies can help stratify patients on a risk basis ensuring the right patients receive antifungals at the optimal time. Using a multidisciplinary approach is also key due to the complexity of managing and treating patients at risk of IFD. Through knowledge sharing, such as The Gilead Antifungal Information Network (GAIN), we hope to drive practices that improve patient management and support the preservation of antifungals for future use.<\/jats:p>","DOI":"10.3390\/jof7100801","type":"journal-article","created":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T04:55:33Z","timestamp":1632718533000},"page":"801","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Lessons from an Educational Invasive Fungal Disease Conference on Hospital Antifungal Stewardship Practices across the UK and Ireland"],"prefix":"10.3390","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1271-2550","authenticated-orcid":false,"given":"Alida Fe","family":"Talento","sequence":"first","affiliation":[{"name":"Department of Microbiology, Children\u2019s Health Ireland at Temple Street, D01 XD99 Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malcolm","family":"Qualie","sequence":"additional","affiliation":[{"name":"NHS England and Improvement, Leicester LE19 1SX, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Cottom","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Glasgow Royal Infirmary, Glasgow G4 0SF, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthijs","family":"Backx","sequence":"additional","affiliation":[{"name":"Mycology Reference Laboratory, Microbiology, Public Health Wales, Cardiff CF14 4XW, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. Lewis","family":"White","sequence":"additional","affiliation":[{"name":"Mycology Reference Laboratory, Microbiology, Public Health Wales, Cardiff CF14 4XW, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,25]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2020, January 14). Ten Threats to Global Health in 2019. Available online: https:\/\/www.who.int\/news-room\/spotlight\/ten-threats-to-global-health-in-2019."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s40506-019-00185-6","article-title":"Do we need antifungal stewardship?","volume":"11","year":"2019","journal-title":"Curr. Treat. Options Infect. Dis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"S328","DOI":"10.1093\/mmy\/myz012","article-title":"Antifungal drugs: What brings the future?","volume":"57","author":"Spriet","year":"2019","journal-title":"Med. 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