{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T11:58:49Z","timestamp":1764331129207,"version":"build-2065373602"},"reference-count":19,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2021,10,18]],"date-time":"2021-10-18T00:00:00Z","timestamp":1634515200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>The SARS-CoV-2 pandemic has proved to be a significant risk addition for invasive infections with Aspergillus. Even though there are plenty of data about the COVID-19-associated pulmonary aspergillosis (CAPA), especially involving Aspergillus fumigatus, recent studies are presenting cases of CAPA involving more than one species of Aspergillus. We report the first case of a SARS-CoV-2 patient associating co-infection with, most likely, Aspergillus section Fumigati and Aspergillus section Flavi from Romania, and we review the existing medical literature in order to shed light upon mixed etiology cases of CAPA. Since mortality remains high in these cases, there is an acute need for more information about the interaction between SARS-CoV-2 and Aspergillus spp., and the therapies for CAPA. The emerging number of cases and the high mortality rate must be considered an incentive for future research.<\/jats:p>","DOI":"10.3390\/jof7100877","type":"journal-article","created":{"date-parts":[[2021,10,19]],"date-time":"2021-10-19T22:52:47Z","timestamp":1634683967000},"page":"877","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Mixed Etiology COVID-19 Associated Pulmonary Aspergillosis (CAPA)\u2014A Case Report and Brief Review of the Literature"],"prefix":"10.3390","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3930-5920","authenticated-orcid":false,"given":"Dan Alexandru","family":"Toc","sequence":"first","affiliation":[{"name":"Department of Microbiology, Iuliu Hatieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania"},{"name":"Cluj County Emergency Hospital, 400000 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Costache","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Iuliu Hatieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania"},{"name":"Cluj County Emergency Hospital, 400000 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8881-7688","authenticated-orcid":false,"given":"Alexandru","family":"Botan","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Iuliu Hatieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Razvan Marian","family":"Mihaila","sequence":"additional","affiliation":[{"name":"Cluj County Emergency Hospital, 400000 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioana Alina","family":"Colosi","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Iuliu Hatieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandor Botond","family":"Buksa","sequence":"additional","affiliation":[{"name":"Cluj County Emergency Hospital, 400000 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roxana Mihaela","family":"Chiorescu","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Iuliu Hatieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania"},{"name":"Cluj County Emergency Hospital, 400000 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.3201\/eid2607.201603","article-title":"Fatal Invasive Aspergillosis and Coronavirus Disease in an Immunocompetent Patient","volume":"26","author":"Blaize","year":"2020","journal-title":"Emerg. Infect. Dis."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jmii.2020.09.004","article-title":"COVID-19 associated with pulmonary aspergillosis: A literature review","volume":"54","author":"Lai","year":"2021","journal-title":"J. Microbiol. Immunol. Infect."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1111\/myc.13213","article-title":"Invasive pulmonary aspergillosis in the COVID-19 era: An expected new entity","volume":"64","author":"Machado","year":"2021","journal-title":"Mycoses"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/jof5030055","article-title":"Invasive aspergillosis by aspergillus flavus: Epidemiology, diagnosis, antifungal resistance, and management","volume":"5","author":"Rudramurthy","year":"2019","journal-title":"J. Fungi"},{"key":"ref_5","unstructured":"Larone, D.H. (2002). Medically Important Fungi. A Guide to Identification, ASM Press. [4th ed.]."},{"key":"ref_6","unstructured":"Kidd, S., Halliday, C., Alexiou, H., and Ellis, D. (2016). Descriptions of Medical Fungi, Newstyle Printing. [3rd ed.]."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.simyco.2014.07.004","article-title":"Phylogeny, identification and nomenclature of the genus Aspergillus","volume":"78","author":"Samson","year":"2014","journal-title":"Stud. Mycol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1093\/cid\/ciz1008","article-title":"Revision and update of the consensus definitions of invasive fungal disease from the european organization for research and treatment of cancer and the mycoses study group education and research consortium","volume":"71","author":"Donnelly","year":"2020","journal-title":"Clin. Infect. Dis."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/jof6030115","article-title":"COVID-19 associated invasive pulmonary aspergillosis: Diagnostic and therapeutic challenges","volume":"6","author":"Mohamed","year":"2020","journal-title":"J. Fungi"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.jfma.2017.06.002","article-title":"Higher mortality of severe influenza patients with probable aspergillosis than those with and without other coinfections","volume":"116","author":"Ku","year":"2017","journal-title":"J. Formos. Med. Assoc."},{"key":"ref_11","first-page":"344","article-title":"Investigation of interleukin-10, tumor necrosis factor-alpha and interferon-gamma expression in experimental model of pulmonary aspergillosis","volume":"45","author":"Fidan","year":"2011","journal-title":"Mikrobiyol. Bul."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/jof6020091","article-title":"COVID-19 associated pulmonary aspergillosis (CAPA)\u2014From immunology to treatment","volume":"6","author":"Arastehfar","year":"2020","journal-title":"J. Fungi"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmicb.2016.00683","article-title":"Aspergillus fumigatus-related species in clinical practice","volume":"7","author":"Lamoth","year":"2016","journal-title":"Front. Microbiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1099\/mic.0.2007\/007641-0","article-title":"Aspergillus flavus: Human pathogen, allergen and mycotoxin producer","volume":"153","author":"Hedayati","year":"2007","journal-title":"Microbiology"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Colosi, I.A., Cognet, O., Colosi, H.A., Sabou, M., and Costache, C. (2020). Dermatophytes and dermatophytosis in Cluj-Napoca, Romania\u2014A 4-year cross-sectional study. J. Fungi, 6.","DOI":"10.3390\/jof6030154"},{"key":"ref_16","first-page":"766","article-title":"COVID-19-associated pulmonary aspergillosis (CAPA) in patients admitted with severe COVID-19 pneumonia: An observational study from Pakistan","volume":"27","author":"Nasir","year":"2020","journal-title":"Emerg. Infect. Dis."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.1002\/ccr3.4051","article-title":"Fatal invasive pulmonary aspergillosis in an immunocompetent patient with COVID-19 due to Aspergillus terreus: A case study","volume":"9","author":"Abolghasemi","year":"2021","journal-title":"Clin. Case Rep."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3201\/eid2701.202896","article-title":"Aspergillosis complicating severe coronavirus disease","volume":"27","author":"Marr","year":"2021","journal-title":"Emerg. Infect. Dis."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1007\/s40121-021-00486-8","article-title":"Epidemiology and Incidence of COVID-19-Associated Pulmonary Aspergillosis (CAPA) in a Greek Tertiary Care Academic Reference Hospital","volume":"10","author":"Paramythiotou","year":"2021","journal-title":"Infect. Dis. Ther."}],"container-title":["Journal of Fungi"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2309-608X\/7\/10\/877\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:17:32Z","timestamp":1760167052000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2309-608X\/7\/10\/877"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,18]]},"references-count":19,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2021,10]]}},"alternative-id":["jof7100877"],"URL":"https:\/\/doi.org\/10.3390\/jof7100877","relation":{},"ISSN":["2309-608X"],"issn-type":[{"type":"electronic","value":"2309-608X"}],"subject":[],"published":{"date-parts":[[2021,10,18]]}}}