{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T16:27:24Z","timestamp":1790353644104,"version":"4.1.0"},"reference-count":61,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,11,12]],"date-time":"2021-11-12T00:00:00Z","timestamp":1636675200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/T001674\/1"],"award-info":[{"award-number":["MR\/T001674\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000615","name":"Fight for Sight","doi-asserted-by":"publisher","award":["MR\/T001674\/1"],"award-info":[{"award-number":["MR\/T001674\/1"]}],"id":[{"id":"10.13039\/501100000615","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>Fungal keratitis (FK) is a serious ocular infection that often poses significant diagnostic and therapeutic dilemmas. This study aimed to examine the causes, clinical characteristics, outcomes, and prognostic factors of FK in the UK. All culture-positive and culture-negative presumed FK (with complete data) that presented to Queen\u2019s Medical Centre, Nottingham, and the Queen Victoria Hospital, East Grinstead, between 2011 and 2020 were included. We included 117 patients (n = 117 eyes) with FK in this study. The mean age was 59.0 \u00b1 19.6 years (range, 4\u201392 years) and 51.3% of patients were female. Fifty-three fungal isolates were identified from 52 (44.4%) culture-positive cases, with Candida spp. (33, 62.3%), Fusarium spp. (9, 17.0%), and Aspergillus spp. (5, 9.4%) being the most common organisms. Ocular surface disease (60, 51.3%), prior corneal surgery (44, 37.6%), and systemic immunosuppression (42, 35.9%) were the three most common risk factors. Hospitalisation for intensive treatment was required for 95 (81.2%) patients, with a duration of 18.9 \u00b1 16.3 days. Sixty-six (56.4%) patients required additional surgical interventions for eradicating the infection. Emergency therapeutic\/tectonic keratoplasty was performed in 29 (24.8%) cases, though 13 (44.8%) of them failed at final follow-up. The final corrected-distance-visual-acuity (CDVA) was 1.67 \u00b1 1.08 logMAR. Multivariable logistic regression analyses demonstrated increased age, large infiltrate size (&gt;3 mm), and poor presenting CDVA (&lt;1.0 logMAR) as significant negative predictive factors for poor visual outcome (CDVA of &lt;1.0 logMAR) and poor corneal healing (&gt;60 days of healing time or occurrence of corneal perforation requiring emergency keratoplasty; all p &lt; 0.05). In conclusion, FK represents a difficult-to-treat ocular infection that often results in poor visual outcomes, with a high need for surgical interventions. Innovative treatment strategies are urgently required to tackle this unmet need.<\/jats:p>","DOI":"10.3390\/jof7110966","type":"journal-article","created":{"date-parts":[[2021,11,14]],"date-time":"2021-11-14T20:51:53Z","timestamp":1636923113000},"page":"966","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Clinical Characteristics and Outcomes of Fungal Keratitis in the United Kingdom 2011\u20132020: A 10-Year Study"],"prefix":"10.3390","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1081-1141","authenticated-orcid":false,"given":"Darren Shu Jeng","family":"Ting","sequence":"first","affiliation":[{"name":"Academic Ophthalmology, Division of Clinical Neuroscience, School of Medicine, University of Nottingham, Nottingham NG7 2RD, UK"},{"name":"Queen\u2019s Medical Centre, Nottingham NG7 2RD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Galal","sequence":"additional","affiliation":[{"name":"Queen Victoria Hospital, East Grinstead RH19 3DZ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6219-1821","authenticated-orcid":false,"given":"Bina","family":"Kulkarni","sequence":"additional","affiliation":[{"name":"Queen\u2019s Medical Centre, Nottingham NG7 2RD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed S.","family":"Elalfy","sequence":"additional","affiliation":[{"name":"Queen Victoria Hospital, East Grinstead RH19 3DZ, UK"},{"name":"Research Institute of Ophthalmology, Giza 12557, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damian","family":"Lake","sequence":"additional","affiliation":[{"name":"Queen Victoria Hospital, East Grinstead RH19 3DZ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samer","family":"Hamada","sequence":"additional","affiliation":[{"name":"Queen Victoria Hospital, East Grinstead RH19 3DZ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalia G.","family":"Said","sequence":"additional","affiliation":[{"name":"Academic Ophthalmology, Division of Clinical Neuroscience, School of Medicine, University of Nottingham, Nottingham NG7 2RD, UK"},{"name":"Queen\u2019s Medical Centre, Nottingham NG7 2RD, UK"},{"name":"Research Institute of Ophthalmology, Giza 12557, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harminder S.","family":"Dua","sequence":"additional","affiliation":[{"name":"Academic Ophthalmology, Division of Clinical Neuroscience, School of Medicine, University of Nottingham, Nottingham NG7 2RD, UK"},{"name":"Queen\u2019s Medical Centre, Nottingham NG7 2RD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1038\/s41433-020-01339-3","article-title":"Infectious keratitis: An update on epidemiology, causative microorganisms, risk factors, and antimicrobial resistance","volume":"35","author":"Ting","year":"2021","journal-title":"Eye"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1136\/bjophthalmol-2018-312881","article-title":"Queensland Microbial Keratitis Database: 2005\u20132015","volume":"103","author":"Green","year":"2019","journal-title":"Br. 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