{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:17:45Z","timestamp":1792095465265,"version":"4.4.0"},"reference-count":85,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2021,11,29]],"date-time":"2021-11-29T00:00:00Z","timestamp":1638144000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>The most important aetiological agent of opportunistic mycoses worldwide is Candida spp. These yeasts can cause severe infections in the host, which may be fatal. Isolates of Candida albicans occur with greater frequency and variable resistance patterns. Photodynamic therapy (PDT) has been recognised as an alternative treatment to kill pathogenic microorganisms. PDT utilises a photosensitizer, which is activated at a specific wavelength and oxygen concentration. Their reaction yields reactive oxygen species that kill the infectious microorganism. A systematic review of new applications of PDT in the management of candidiasis was performed. Of the 222 studies selected for in-depth screening, 84 were included in this study. All the studies reported the antifungal effectiveness, toxicity and dosimetry of treatment with antimicrobial PDT (aPDT) with different photosensitizers against Candida spp. The manuscripts that are discussed reveal the breadth of the new applications of aPDT against Candida spp., which are resistant to common antifungals. aPDT has superior performance compared to conventional antifungal therapies. With further studies, aPDT should prove valuable in daily clinical practice.<\/jats:p>","DOI":"10.3390\/jof7121025","type":"journal-article","created":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T01:43:22Z","timestamp":1638323002000},"page":"1025","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["New Applications of Photodynamic Therapy in the Management of Candidiasis"],"prefix":"10.3390","volume":"7","author":[{"given":"Carmen","family":"Rodr\u00edguez-Cerdeira","sequence":"first","affiliation":[{"name":"Efficiency, Quality and Costs in Health Services Research Group (EFISALUD), Health Research Institute, SERGAS-UVIGO, 36213 Vigo, Spain"},{"name":"Dermatology Department, Hospital do Vithas Ntra. Sra. de Fatima, 36206 Vigo, Spain"},{"name":"Campus of Vigo, University of Vigo, As Lagoas, 36310 Vigo, Spain"},{"name":"European Women\u2019s Dermatologic and Venereologic Society (EWDVS), 36700 Tui, Spain"},{"name":"Psychodermatology Task Force of the Ibero-Latin American College of Dermatology (CILAD), Buenos Aires 2019, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7298-158X","authenticated-orcid":false,"given":"Erick","family":"Mart\u00ednez-Herrera","sequence":"additional","affiliation":[{"name":"Efficiency, Quality and Costs in Health Services Research Group (EFISALUD), Health Research Institute, SERGAS-UVIGO, 36213 Vigo, Spain"},{"name":"European Women\u2019s Dermatologic and Venereologic Society (EWDVS), 36700 Tui, Spain"},{"name":"Psychodermatology Task Force of the Ibero-Latin American College of Dermatology (CILAD), Buenos Aires 2019, Argentina"},{"name":"Research Unit, Regional Hospital of High Specialty of Ixtapaluca, Ixtapaluca 56530, Mexico"},{"name":"Postgraduate Studies and Research Section, Higher School of Medicine, National Polytechnic Institute, Ciudad de M\u00e9xico 07340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Fabbrocini","sequence":"additional","affiliation":[{"name":"European Women\u2019s Dermatologic and Venereologic Society (EWDVS), 36700 Tui, Spain"},{"name":"Department of Dermatology, University of Naples Federico II, 80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Sanchez-Blanco","sequence":"additional","affiliation":[{"name":"Efficiency, Quality and Costs in Health Services Research Group (EFISALUD), Health Research Institute, SERGAS-UVIGO, 36213 Vigo, Spain"},{"name":"Campus of Vigo, University of Vigo, As Lagoas, 36310 Vigo, Spain"},{"name":"European Women\u2019s Dermatologic and Venereologic Society (EWDVS), 36700 Tui, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"L\u00f3pez-Barcenas","sequence":"additional","affiliation":[{"name":"European Women\u2019s Dermatologic and Venereologic Society (EWDVS), 36700 Tui, Spain"},{"name":"Psychodermatology Task Force of the Ibero-Latin American College of Dermatology (CILAD), Buenos Aires 2019, Argentina"},{"name":"Dermatology Department (Section Mycology), Manuel Gea Gonz\u00e1lez Hospital, Tlalpan, Ciudad de M\u00e9xico 14080, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"May","family":"EL-Samahy","sequence":"additional","affiliation":[{"name":"European Women\u2019s Dermatologic and Venereologic Society (EWDVS), 36700 Tui, Spain"},{"name":"Department of Dermatology, University of Medicine, Ain Schams, Cairo 11591, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eder R.","family":"Ju\u00e1rez-Dur\u00e1n","sequence":"additional","affiliation":[{"name":"Efficiency, Quality and Costs in Health Services Research Group (EFISALUD), Health Research Institute, SERGAS-UVIGO, 36213 Vigo, Spain"},{"name":"Psychodermatology Task Force of the Ibero-Latin American College of Dermatology (CILAD), Buenos Aires 2019, Argentina"},{"name":"Dermatology Department (Section Mycology), Manuel Gea Gonz\u00e1lez Hospital, Tlalpan, Ciudad de M\u00e9xico 14080, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Lu\u00eds","family":"Gonz\u00e1lez-Cesp\u00f3n","sequence":"additional","affiliation":[{"name":"Efficiency, Quality and Costs in Health Services Research Group (EFISALUD), Health Research Institute, SERGAS-UVIGO, 36213 Vigo, Spain"},{"name":"Campus of Vigo, University of Vigo, As Lagoas, 36310 Vigo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/978-1-4419-5638-5_10","article-title":"Models Hosts for the Study of Oral Candidiasis","volume":"710","author":"Junqueira","year":"2012","journal-title":"Adv. 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