{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T20:23:17Z","timestamp":1793046197020,"version":"4.5.0"},"reference-count":22,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,12,27]],"date-time":"2021-12-27T00:00:00Z","timestamp":1640563200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>Disseminated histoplasmosis is a common differential diagnosis of tuberculosis in disease-endemic areas. We aimed to find a predictive score to orient clinicians towards disseminated histoplasmosis or tuberculosis when facing a non-specific infectious syndrome in patients with advanced HIV disease. We reanalyzed data from a retrospective study in Cayenne Hospital between January 1997\u2013December 2008 comparing disseminated histoplasmosis and tuberculosis: 100 confirmed disseminated histoplasmosis cases and 88 confirmed tuberculosis cases were included. A simple logit regression model was constructed to predict whether a case was tuberculosis or disseminated histoplasmosis. From this model, a score may be obtained, where the natural logarithm of the probability of disseminated histoplasmosis\/tuberculosis = +3.917962 \u00d7 WHO performance score (1 if &gt;2, 0 if \u22642) \u22121.624642 \u00d7 Pulmonary presentation (1 yes, 0 no) +2.245819 \u00d7 Adenopathies &gt; 2 cm (1 yes, 0 no) \u22120.015898 \u00d7 CD4 count \u2212 0.001851 \u00d7 ASAT \u2212 0.000871 \u00d7 Neutrophil count \u2212 0.000018 \u00d7 Platelet count + 6.053793. The area under the curve was 98.55%. The sensitivity of the model to distinguish between disseminated histoplasmosis and tuberculosis was 95% (95% CI = 88.7\u201398.3%), and the specificity was 93% (95% CI = 85.7.3\u201397.4%). In conclusion, we here present a clinical-biological predictive score, using simple variables available on admission, that seemed to perform very well to discriminate disseminated histoplasmosis from tuberculosis in French Guiana in well characterized patients.<\/jats:p>","DOI":"10.3390\/jof8010016","type":"journal-article","created":{"date-parts":[[2021,12,28]],"date-time":"2021-12-28T01:20:43Z","timestamp":1640654443000},"page":"16","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A Simple Predictive Score to Distinguish between Disseminated Histoplasmosis and Tuberculosis in Patients with HIV"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9397-3204","authenticated-orcid":false,"given":"Mathieu","family":"Nacher","sequence":"first","affiliation":[{"name":"CIC INSERM 1424, Centre Hospitalier de Cayenne, 97300 Cayenne, French Guiana"},{"name":"D\u00e9partement Formation Recherche, Universit\u00e9 de Guyane, 97300 Cayenne, French Guiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kinan","family":"Drak Alsibai","sequence":"additional","affiliation":[{"name":"Service d\u2019anatomopathologie, Centre Hospitalier de Cayenne, 97300 Cayenne, French Guiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lo\u00efc","family":"Epelboin","sequence":"additional","affiliation":[{"name":"Service des Maladies Infectieuses et Tropicales, Centre Hospitalier de Cayenne, 97300 Cayenne, French Guiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Abboud","sequence":"additional","affiliation":[{"name":"Service des Maladies Infectieuses et Tropicales, Centre Hospitalier de Cayenne, 97300 Cayenne, French Guiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9gonde","family":"About","sequence":"additional","affiliation":[{"name":"Service des Maladies Infectieuses et 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Guiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4000-4981","authenticated-orcid":false,"given":"Antoine","family":"Adenis","sequence":"additional","affiliation":[{"name":"CIC INSERM 1424, Centre Hospitalier de Cayenne, 97300 Cayenne, French Guiana"},{"name":"D\u00e9partement Formation Recherche, Universit\u00e9 de Guyane, 97300 Cayenne, French Guiana"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Nacher, M., Adriouch, L., Huber, F., Vantilcke, V., Djossou, F., Elenga, N., Adenis, A., and Couppi\u00e9, P. 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