{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:55:55Z","timestamp":1790812555670,"version":"4.1.0"},"reference-count":21,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T00:00:00Z","timestamp":1644364800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>Candida blankii is a recently recognized human pathogen, with most cases of the infection being reported in the immunocompromised. We here describe the case of a critically ill elderly woman with COVID-19 who developed a C. blankii bloodstream infection from a femoral central venous catheter. Aspergillus niger was also isolated from her respiratory secretions. The patient was started on voriconazole for empiric coverage of both A. niger, and at that time, unidentified yeast was found in the blood. Fevers persisted, and the patient expired six days after the yeast was first isolated. Almost one month after her death, C. blankii was identified as the cause of fungemia by sequencing of the internal transcribed spacer (ITS) region of the ribosomal gene and BLAST searching against two databases (performed by a reference laboratory). The isolate demonstrated high minimum inhibitory concentrations (MICs) to azoles and low MICs to amphotericin B, similar to previously described isolates. Timely identification of C. blankii would have prompted different empiric antifungal choices and possibly changed the final outcome. Clinicians should be aware of the pathological potential of C. blankii, the challenges of correctly identifying the organism, and its susceptibility patterns to common antifungals. There is an urgent need to improve assays for C. blankii identification, which will aid in accurate and timely pathogen identification, and appropriate therapeutic management.<\/jats:p>","DOI":"10.3390\/jof8020166","type":"journal-article","created":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T21:22:15Z","timestamp":1644441735000},"page":"166","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["The Continuing Emergence of Candida blankii as a Pathogenic Fungus: A New Case of Fungemia in a Patient Infected with SARS-CoV-2"],"prefix":"10.3390","volume":"8","author":[{"given":"Ryan","family":"Mirchin","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, New York Presbyterian\u2014Queens, Flushing, NY 11355, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan M.","family":"Czeresnia","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY 10467, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika P.","family":"Orner","sequence":"additional","affiliation":[{"name":"Department of Pathology, Montefiore Medical Center, Bronx, NY 10467, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudha","family":"Chaturvedi","sequence":"additional","affiliation":[{"name":"Wadsworth Center Mycology Laboratory, New York State Department of Health, Albany, NY 12208, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerry","family":"Murphy","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY 10467, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9905-5754","authenticated-orcid":false,"given":"Joshua D.","family":"Nosanchuk","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY 10467, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/BF02050372","article-title":"Five new Candida species","volume":"36","author":"Buckley","year":"1968","journal-title":"Mycopathol. Mycol. Appl."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"172","DOI":"10.3923\/ijds.2011.172.180","article-title":"Chemical Composition and Microbial Load of Set Yoghurt from Fresh and Recombined Milk Powder in Khartoum State, Sudan","volume":"6","author":"Mohammad","year":"2011","journal-title":"Int. J. Dairy Sci."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"S140","DOI":"10.1016\/S1569-1993(15)30492-6","article-title":"318 Candida blankii: New agent in cystic fibrosis airways?","volume":"14","author":"Zaragoza","year":"2015","journal-title":"J. Cyst. Fibros."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.nmni.2018.06.008","article-title":"Azole-resistant Candida blankii as a newly recognized cause of bloodstream infection","volume":"26","author":"Ahmad","year":"2018","journal-title":"New Microbes New Infect."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"648.e645","DOI":"10.1016\/j.cmi.2020.01.001","article-title":"Candida blankii: An emerging yeast in an outbreak of fungaemia in neonates in Delhi, India","volume":"26","author":"Chowdhary","year":"2020","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_6","first-page":"24","article-title":"Candida blankii: An emergent opportunistic yeast with reduced susceptibility to antifungals","volume":"7","author":"Campos","year":"2018","journal-title":"Emerg. Microbes Infect."},{"key":"ref_7","first-page":"e14945","article-title":"A Report of Candida blankii Fungemia and Possible Endocarditis in an Immunocompetent Individual and the Review of Literature","volume":"13","author":"Kollu","year":"2021","journal-title":"Cureus"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Ferreira, C., Viana, S.D., and Reis, F. (2021). Is Gut Microbiota Dysbiosis a Predictor of Increased Susceptibility to Poor Outcome of COVID-19 Patients? An Update. Microorganisms, 9.","DOI":"10.3390\/microorganisms9010053"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Rodrigues, M.L., and Nosanchuk, J.D. (2020). Fungal diseases as neglected pathogens: A wake-up call to public health officials. PLoS Negl. Trop. Dis., 14.","DOI":"10.1371\/journal.pntd.0007964"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s13613-020-00686-4","article-title":"COVID-19-associated invasive pulmonary aspergillosis","volume":"10","author":"Rutsaert","year":"2020","journal-title":"Ann. Intensive Care"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1016\/j.cmi.2021.06.025","article-title":"COVID-19-associated pulmonary aspergillosis (CAPA): How big a problem is it?","volume":"27","author":"Fekkar","year":"2021","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"102146","DOI":"10.1016\/j.dsx.2021.05.019","article-title":"Mucormycosis in COVID-19: A systematic review of cases reported worldwide and in India","volume":"15","author":"Singh","year":"2021","journal-title":"Diabetes Metab. Syndr. Clin. Res. Rev."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Yasmin, F., Najeeb, H., Naeem, A., Dapke, K., Phadke, R., Asghar, M.S., Shah, S.M.I., De Berardis, D., and Ullah, I. (2021). COVID-19 Associated Mucormycosis: A Systematic Review from Diagnostic Challenges to Management. Diseases, 9.","DOI":"10.3390\/diseases9040065"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"de Almeida, J.N., Francisco, E.C., Hagen, F., Brandao, I.B., Pereira, F.M., Presta Dias, P.H., de Miranda Costa, M.M., de Souza Jordao, R.T., de Groot, T., and Colombo, A.L. (2021). Emergence of Candida auris in Brazil in a COVID-19 Intensive Care Unit. J. Fungi, 7.","DOI":"10.3390\/jof7030220"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.cmi.2020.12.030","article-title":"Outbreak of Candida auris infection in a COVID-19 hospital in Mexico","volume":"27","author":"Gonzalez","year":"2021","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Ventoulis, I., Sarmourli, T., Amoiridou, P., Mantzana, P., Exindari, M., Gioula, G., and Vyzantiadis, T.A. (2020). Bloodstream Infection by Saccharomyces cerevisiae in Two COVID-19 Patients after Receiving Supplementation of Saccharomyces in the ICU. J. Fungi, 6.","DOI":"10.3390\/jof6030098"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1111\/myc.13333","article-title":"Trichosporon asahii superinfections in critically ill COVID-19 patients overexposed to antimicrobials and corticosteroids","volume":"64","author":"Moreno","year":"2021","journal-title":"Mycoses"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1093\/jac\/dkz568","article-title":"MIC distributions for amphotericin B, fluconazole, itraconazole, voriconazole, flucytosine and anidulafungin and 35 uncommon pathogenic yeast species from the UK determined using the CLSI broth microdilution method","volume":"75","author":"Borman","year":"2020","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e00360-21","DOI":"10.1128\/mBio.00360-21","article-title":"Environmental Candida auris and the Global Warming Emergence Hypothesis","volume":"12","author":"Casadevall","year":"2021","journal-title":"mBio"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.3201\/eid2704.204895","article-title":"COVID-19-Associated Pulmonary Aspergillosis, March-August 2020","volume":"27","author":"Sprute","year":"2021","journal-title":"Emerg. Infect. Dis."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"640644","DOI":"10.3389\/fimmu.2021.640644","article-title":"COVID-19 Impairs Immune Response to Candida albicans","volume":"12","author":"Moser","year":"2021","journal-title":"Front. Immunol."}],"container-title":["Journal of Fungi"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2309-608X\/8\/2\/166\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:16:36Z","timestamp":1760134596000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2309-608X\/8\/2\/166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,9]]},"references-count":21,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,2]]}},"alternative-id":["jof8020166"],"URL":"https:\/\/doi.org\/10.3390\/jof8020166","relation":{},"ISSN":["2309-608X"],"issn-type":[{"value":"2309-608X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,9]]}}}