{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:22:58Z","timestamp":1792174978557,"version":"4.4.0"},"reference-count":90,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,3,4]],"date-time":"2022-03-04T00:00:00Z","timestamp":1646352000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>Schistosomiasis is a tropical disease with socioeconomic problems. The goal of this study was to determine the influence of myco-synthesized nano-selenium (SeNPs) as a molluscicide on Biomphlaria alexandrina snails, with the goal of reducing disease spread via non-toxic routes. In this study, Penicillium chrysogenum culture filtrate metabolites were used as a reductant for selenium ions to form nano-selenium. The SeNPs were characterized via UV-Vis spectrophotometer, Fourier transform infrared (FT-IR) spectroscopy, transmission electron microscopy (TEM), dynamic light scattering (DLS), and X-ray diffraction (XRD). Myco-synthesized SeNPs had a significant molluscicidal effect on B. alexandrina snails after 96 h of exposure at a concentration of 5.96 mg\/L. SeNPs also had miracidicidal and cercaricidal properties against S. mansoni. Some alterations were observed in the hemocytes of snails exposed to SeNPs, including the formation of pseudopodia and an increasing number of granules. Furthermore, lipid peroxide, nitric oxide (NO), malondialdehyde (MDA), and glutathione s-transferase (GST) increased significantly in a dose-dependent manner, while superoxide dismutase (SOD) decreased. The comet assay revealed that myco-synthesized SeNPs could cause breaks in the DNA levels. In silico study revealed that SeNPs had promising antioxidant properties. In conclusion, myco-synthesized SeNPs have the potential to be used as molluscicides and larvicides.<\/jats:p>","DOI":"10.3390\/jof8030262","type":"journal-article","created":{"date-parts":[[2022,3,6]],"date-time":"2022-03-06T20:38:16Z","timestamp":1646599096000},"page":"262","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Myco-Synthesized Molluscicidal and Larvicidal Selenium Nanoparticles: A New Strategy to Control Biomphalaria alexandrina Snails and Larvae of Schistosoma mansoni with an In Silico Study on Induced Oxidative Stress"],"prefix":"10.3390","volume":"8","author":[{"given":"Mostafa Y.","family":"Morad","sequence":"first","affiliation":[{"name":"Zoology and Entomology Department, Faculty of Science, Helwan University, Helwan 11795, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2962-6755","authenticated-orcid":false,"given":"Heba","family":"El-Sayed","sequence":"additional","affiliation":[{"name":"Botany and Microbiology Department, Faculty of Science, Helwan University, Helwan 11795, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2893-0376","authenticated-orcid":false,"given":"Ahmed A.","family":"Elhenawy","sequence":"additional","affiliation":[{"name":"Chemistry Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo 11884, Egypt"},{"name":"Chemistry Department, Faculty of Science and Art, Al Baha University, Mukhwah, Al Baha 6531, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9355-3952","authenticated-orcid":false,"given":"Shereen M.","family":"Korany","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abeer S.","family":"Aloufi","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amina M.","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Medical Malacology Department, Theodor Bilharz Research Institute, Giza 12411, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,4]]},"reference":[{"key":"ref_1","unstructured":"(2022, February 11). WHO Schistosomiasis. 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