{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T03:30:40Z","timestamp":1771644640742,"version":"3.50.1"},"reference-count":26,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T00:00:00Z","timestamp":1646697600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>The COVID-19 pandemic has led to a dramatic rise in the incidence of rhino-orbito-cerebral mucormycosis (ROCM) in India. The purpose of our report is to describe the prevalence of ROCM in the context of SARS-CoV-2 infection during the second Indian COVID-19 wave, as well as its diagnostics proceeding, and to discuss the challenges met in the time frame from the suspected diagnosis to the therapeutic decision in such patients. We conducted a retrospective multicentre case series study at six centres of Sudhalkar and Raghudeep group of hospitals in India. ROCM was confirmed in 38 (2.5%) of the 1546 patients admitted with SARS-CoV-2 infection. The average time to establish a diagnosis was 16 days. In total, 19 (50%) patients suffered from type 2 diabetes and were mostly treated with hypoglycaemic agents (in 90% of cases). The standard of care for SARS-CoV-2 management included systemic steroids therapy, intravenous remdesivir for 5 days, and concomitant prophylactic antibiotic therapy following admission. The median (IQR) blood glucose levels in all patients during the course of hospitalisation was 320 (250.5\u2013375) mg\/dl. A total of 16% of patients had an irreparable functional loss, and the mortality was 5%. We may hypothesise that excessive administration of antibiotics that profoundly affects human microbiota, coupled with poorly controlled glycaemia and unprotocolised haphazard steroid administration, contribute to a favourable setting for mucormycosis infections.<\/jats:p>","DOI":"10.3390\/jof8030271","type":"journal-article","created":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T12:35:37Z","timestamp":1646742937000},"page":"271","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Risk Factors for COVID-19 Associated Mucormycosis: The Ophthalmologist\u2019s Perspective"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8403-0853","authenticated-orcid":false,"given":"Alper","family":"Bilgic","sequence":"first","affiliation":[{"name":"Alphavision Augenarztpraxis, 27568 Bremerhaven, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3908-6716","authenticated-orcid":false,"given":"Laurent","family":"Kodjikian","sequence":"additional","affiliation":[{"name":"Service d\u2019Ophtalmologie, Centre Hospitalier Universitaire de la Croix-Rousse, Hospices Civils de Lyon, Universit\u00e9 Claude Bernard Lyon 1, 69004 Lyon, France"},{"name":"UCBL, INSA Lyon, CNRS, MATEIS UMR5510, Universit\u00e9 de Lyon, 69100 Villeurbanne, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aditya","family":"Sudhalkar","sequence":"additional","affiliation":[{"name":"Alphavision Augenarztpraxis, 27568 Bremerhaven, Germany"},{"name":"MS Sudhalkar Medical Research Foundation, Baroda 390001, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2432-9911","authenticated-orcid":false,"given":"Shyamal","family":"Dwivedi","sequence":"additional","affiliation":[{"name":"MS Sudhalkar Medical Research Foundation, Baroda 390001, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viraj","family":"Vasavada","sequence":"additional","affiliation":[{"name":"MS Sudhalkar Medical Research Foundation, Baroda 390001, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arpan","family":"Shah","sequence":"additional","affiliation":[{"name":"Pranayam Heart and Lung Institute, Baroda 390001, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5116-2171","authenticated-orcid":false,"given":"Mikhail","family":"Dziadzko","sequence":"additional","affiliation":[{"name":"Service d\u2019Ophtalmologie, Centre Hospitalier Universitaire de la Croix-Rousse, Hospices Civils de Lyon, Universit\u00e9 Claude Bernard Lyon 1, 69004 Lyon, France"},{"name":"INSERM, U1290 RESHAPE, Universit\u00e9 Claude Bernard Lyon 1, 69004 Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thibaud","family":"Mathis","sequence":"additional","affiliation":[{"name":"Service d\u2019Ophtalmologie, Centre Hospitalier Universitaire de la Croix-Rousse, Hospices Civils de Lyon, Universit\u00e9 Claude Bernard Lyon 1, 69004 Lyon, France"},{"name":"UCBL, INSA Lyon, CNRS, MATEIS UMR5510, Universit\u00e9 de Lyon, 69100 Villeurbanne, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,8]]},"reference":[{"key":"ref_1","unstructured":"Ak, A.K., and Gupta, V. 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