{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T13:53:45Z","timestamp":1786629225775,"version":"build-2736575974"},"reference-count":54,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T00:00:00Z","timestamp":1647475200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>New biomarker panel was developed and validated on 165 critically ill adult patients to enable a more accurate invasive candidiasis (IC) diagnosis. Serum levels of the panfungal biomarker (1,3)-\u03b2-D-glucan (BDG) and the inflammatory biomarkers C-reactive protein, presepsin (PSEP), and procalcitonin (PCT) were correlated with culture-confirmed candidemia or bacteremia in 58 and 107 patients, respectively. The diagnostic utility was evaluated in sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV). BDG was the best marker for IC, achieving 96.6% sensitivity, 97.2% specificity, 94.9% PPV, and 98.1% NPV at a cut-off of 200 pg\/mL (p\u00a0\u2264 0.001). PSEP exhibited 100% sensitivity and 100% NPV at a cut-off of 700 pg\/mL but had a lower PPV (36.5%) and low specificity (5.6%). Combined use of PSEP and BDG, thus, seems to be the most powerful laboratory approach for diagnosing IC. Furthermore, PSEP was more accurate for 28-day mortality prediction the area under the receiver operating characteristic curve (AUC = 0.74) than PCT (AUC = 0.31; PCT cut-off = 0.5 ng\/mL). Finally, serum PSEP levels decreased significantly after only 14 days of echinocandin therapy (p = 0.0012). The probability of IC is almost 100% in critically ill adults with serum BDG and PSEP concentrations &gt; 200 pg\/mL and &gt;700 pg\/mL, respectively, defining a borderline between non-invasive superficial Candida colonization and IC.<\/jats:p>","DOI":"10.3390\/jof8030308","type":"journal-article","created":{"date-parts":[[2022,3,20]],"date-time":"2022-03-20T21:30:14Z","timestamp":1647811814000},"page":"308","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Combined Use of Presepsin and (1,3)-\u03b2-D-glucan as Biomarkers for Diagnosing Candida Sepsis and Monitoring the Effectiveness of Treatment in Critically Ill Patients"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4299-9169","authenticated-orcid":false,"given":"Radim","family":"Dobi\u00e1\u0161","sequence":"first","affiliation":[{"name":"Department of Bacteriology and Mycology, Public Health Institute in Ostrava, 702 00 Ostrava, Czech Republic"},{"name":"Institute of Laboratory Medicine, Faculty of Medicine, University of Ostrava, 703 00 Ostrava, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8880-8925","authenticated-orcid":false,"given":"Marcela","family":"K\u00e1\u0148ov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine, University Hospital Ostrava, 708 00 Ostrava, Czech Republic"},{"name":"Institute of Physiology and Pathophysiology, Faculty of Medicine, University of Ostrava, 710 00 Ostrava, Czech Republic"},{"name":"Department of Intensive Medicine, Emergency Medicine and Forensic Studies, University of Ostrava, 710 00 Ostrava, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nad\u011b\u017eda","family":"Petejov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University Hospital Ostrava, 708 00 Ostrava, Czech Republic"},{"name":"Department of Internal Medicine, University of Ostrava, 703 00 Ostrava, Czech Republic"},{"name":"Department of Internal Medicine III\u2014Nephrology, Rheumatology and Endocrinology, Faculty of Medicine and Dentistry, Palack\u00fd University Olomouc, 775 15 Olomouc, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0160tefan Kis","family":"Pisti","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Resuscitation, Ostrava City Hospital, 728 80 Ostrava, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Bocek","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Resuscitation, Hospital with Polyclinic Hav\u00ed\u0159ov, 736 01 Hav\u00ed\u0159ov, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Krej\u010d\u00ed","sequence":"additional","affiliation":[{"name":"Department of 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of Public Health in Ostrava, 702 00 Ostrava, Czech Republic"},{"name":"Department of Epidemiology and Public Health, Faculty of Medicine, University of Ostrava, 703 00 Ostrava, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5361-8125","authenticated-orcid":false,"given":"Petr","family":"Hamal","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine and Dentistry, Palack\u00fd University Olomouc, 775 15 Olomouc, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8614-7059","authenticated-orcid":false,"given":"Vladim\u00edr","family":"Havl\u00ed\u010dek","sequence":"additional","affiliation":[{"name":"Institute of Microbiology of the Czech Academy of Sciences, 142 20 Prague, Czech Republic"},{"name":"Department of Analytical Chemistry, Faculty of Science, Palack\u00fd University, 771 46 Olomouc, Czech 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