{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T11:25:56Z","timestamp":1773314756374,"version":"3.50.1"},"reference-count":33,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T00:00:00Z","timestamp":1648512000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>Objective: To systematically review literature enabling the comparison of the efficacy of pharmaceutical treatments for tinea pedis in adults. Design: Systematic review of randomised controlled trials (RCTs) with mycological cure as the primary outcome. Secondary outcomes did include the clinical assessment of resolving infection or symptoms, duration of treatment, adverse events, adherence, and recurrence. Eligibility Criteria: Study participants suffering from only tinea pedis that were treated with a pharmaceutical treatment. The study must have been conducted using an RCT study design and recording age of the participant &gt; 16 years of age. Results: A total of seven studies met the inclusion criteria, involving 1042 participants. The likelihood of resolution in study participants treated with terbinafine was RR 3.9 (95% CI: 2.0\u20137.8) times those with a placebo. Similarly, the allylamine butenafine was effective by RR 5.3 (95% CI: 1.4\u201319.6) compared to a placebo. Butenafine was similarly efficacious to terbinafine RR 1.3 (95% CI: 0.4\u20134.4). Terbinafine was marginally more efficacious than itraconazole, RR 1.3 (95% CI: 1.1\u20131.5). Summary\/Conclusion: Topical terbinafine and butenafine treatments of tinea pedis were more efficacious than placebo. Tableted terbinafine and itraconazole administered orally were efficacious in the drug treatment of tinea pedis fungal infection. We are concerned about how few studies were available that reported the baseline characteristics for each treatment arm and that did not suffer greater than 20% loss to follow-up. We would like to see improved reporting of clinical trials in academic literature. Registration name: Treatment\u2019s for athlete\u2019s foot\u2014systematic review with meta-analysis [CRD42020162078].<\/jats:p>","DOI":"10.3390\/jof8040351","type":"journal-article","created":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T21:41:30Z","timestamp":1648590090000},"page":"351","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Consensus for the Treatment of Tinea Pedis: A Systematic Review of Randomised Controlled Trials"],"prefix":"10.3390","volume":"8","author":[{"given":"Harry","family":"Ward","sequence":"first","affiliation":[{"name":"Versus Arthritis Centre for Sport, Exercise and Osteoarthritis Research, University of Nottingham, Nottingham NG7 2UH, UK"},{"name":"Bodleian Health Care Libraries, Oxford University, Oxford OX3 9DU, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Parkes","sequence":"additional","affiliation":[{"name":"Versus Arthritis Centre for Sport, Exercise and Osteoarthritis Research, University of Nottingham, Nottingham NG7 2UH, UK"},{"name":"Bodleian Health Care Libraries, Oxford University, Oxford OX3 9DU, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolyn","family":"Smith","sequence":"additional","affiliation":[{"name":"Bodleian Health Care Libraries, Oxford University, Oxford OX3 9DU, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Kluzek","sequence":"additional","affiliation":[{"name":"Orthopaedics, Trauma and Sports Medicine, School of Medicine, Queen\u2019s Medical, Centre University of Nottingham, Nottingham NG7 2UH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Pearson","sequence":"additional","affiliation":[{"name":"Orthopaedics, Trauma and Sports Medicine, School of Medicine, Queen\u2019s Medical, Centre University of Nottingham, Nottingham NG7 2UH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"612","DOI":"10.3113\/FAI.2012.0612","article-title":"Topical Review: Skin Infections in the Foot and Ankle Patient","volume":"33","author":"Hsu","year":"2012","journal-title":"Foot Ankle Int."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"S120","DOI":"10.1067\/mjd.2000.110378","article-title":"Dermatophytosis: Epidemiological and microbiological update","volume":"43","author":"Rinaldi","year":"2000","journal-title":"J. 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