{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:52:06Z","timestamp":1787028726214,"version":"build-2736575974"},"reference-count":72,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T00:00:00Z","timestamp":1652140800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Brazilian National Council for Scientific and Technological Development","award":["307432\/2019-0"],"award-info":[{"award-number":["307432\/2019-0"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>Lobomycosis is a chronic disease caused by Lacazia loboi, which is endemic to the Amazon rainforest, where it affects forest dwellers in Brazil. There is no disease control program and no official therapeutic protocol. This situation contributes to an unknown disease prevalence and unmet needs of people disabled by this disease who seek access to treatment. This review provides an update on the subject with an emphasis on therapeutic advances in humans. All relevant studies that addressed epidemiology, diagnosis, or therapeutics of lobomycosis were considered. Seventy-one articles published between 1931 and 2021 were included for a narrative literature review on the epidemiology and quest for a cure. An effective therapy for lobomycosis has been found following decades of research led by the State Dermatology Program of Acre in the Amazon rainforest, where the largest number of cases occur. This discovery opened new avenues for future studies. The main recommendations here, addressed to the Brazilian Ministry of Health, are for lobomycosis to become a reportable disease to ensure that disease prevalence is measured, and that it be prioritized such that affected individuals may access treatment free-of-charge.<\/jats:p>","DOI":"10.3390\/jof8050494","type":"journal-article","created":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T08:31:55Z","timestamp":1652171515000},"page":"494","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Lobomycosis Epidemiology and Management: The Quest for a Cure for the Most Neglected of Neglected Tropical Diseases"],"prefix":"10.3390","volume":"8","author":[{"given":"Franciely G.","family":"Gon\u00e7alves","sequence":"first","affiliation":[{"name":"Graduate Research and Innovation Program, Centro Universitario FMABC, Santo Andr\u00e9 09060-870, SP, Brazil"},{"name":"Research Lab at Centro Universitario UNINORTE, Rio Branco 69915-901, AC, Brazil"},{"name":"State Dermatology Program of Acre, Secretariat of Health in the State of Acre (SESACRE), Rio Branco 69917-650, AC, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia S.","family":"Rosa","sequence":"additional","affiliation":[{"name":"Division of Research, Lauro de Souza Lima Institute, Bauru 17034-971, AP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea de F. F.","family":"Belone","sequence":"additional","affiliation":[{"name":"Division of Research, Lauro de Souza Lima Institute, Bauru 17034-971, AP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e9ia B.","family":"Carneiro","sequence":"additional","affiliation":[{"name":"State Dermatology Program of Acre, Secretariat of Health in the State of Acre (SESACRE), Rio Branco 69917-650, AC, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vania L. Q.","family":"de Barros","sequence":"additional","affiliation":[{"name":"State Dermatology Program of Acre, Secretariat of Health in the State of Acre (SESACRE), Rio Branco 69917-650, AC, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosineide F.","family":"Bispo","sequence":"additional","affiliation":[{"name":"State Dermatology Program of Acre, Secretariat of Health in the State of Acre (SESACRE), Rio Branco 69917-650, AC, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yally A. da S.","family":"Sbardelott","sequence":"additional","affiliation":[{"name":"State Dermatology Program of Acre, Secretariat of Health in the State of Acre (SESACRE), Rio Branco 69917-650, AC, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebasti\u00e3o A. V. M.","family":"Neves","sequence":"additional","affiliation":[{"name":"School of Medicine, Federal University of Acre, Rio Branco 69920-900, AC, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy Y.","family":"Vittor","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Global Medicine, Department of Medicine, College of Medicine, University of Florida, Gainesville, FL 32610, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"Woods","sequence":"additional","affiliation":[{"name":"State Dermatology Program of Acre, Secretariat of Health in the State of Acre (SESACRE), Rio Branco 69917-650, AC, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7412-9390","authenticated-orcid":false,"given":"Gabriel Z.","family":"Laporta","sequence":"additional","affiliation":[{"name":"Graduate Research and Innovation Program, Centro Universitario FMABC, Santo Andr\u00e9 09060-870, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1590\/S0365-05962007000500010","article-title":"Lacaziose (doen\u00e7a de Jorge Lobo): Revis\u00e3o e atualiza\u00e7\u00e3o","volume":"82","author":"Quaresma","year":"2007","journal-title":"An. Bras. Dermatol."},{"key":"ref_2","unstructured":"Lacaz, C.S., Baruzzi, R.G., and Rosa, M.C.B. (1986). Doen\u00e7a de Jorge Lobo, EDUSP."},{"key":"ref_3","first-page":"763","article-title":"Um caso de blastomicose, produzido por uma esp\u00e9cie nova, encontrada em Recife","volume":"1","author":"Lobo","year":"1931","journal-title":"Rev. Med. Pernamb."},{"key":"ref_4","first-page":"1200","article-title":"Pele e anexos","volume":"Volume 1","year":"2006","journal-title":"Bogliolo Patologia"},{"key":"ref_5","unstructured":"Trabulsi, L.R., and Alterthum, F. (2008). Micoses subcut\u00e2neas. Microbiologia, Atheneu. [5th ed.]."},{"key":"ref_6","first-page":"777","article-title":"A possible case of Lobo\u2019s diseases acquired in Europe from a bottle-nosed dolphin (Tursiops truncates)","volume":"76","author":"Symeres","year":"1983","journal-title":"Bull. Soci\u00e9t\u00e9 Pathol. Exot. Fil."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1111\/j.1748-7692.1993.tb00462.x","article-title":"First case of lobomycosis in a bottlenose dolphin from southern Brazil","volume":"9","author":"Paula","year":"1993","journal-title":"Mar. Mamm. Sci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"64","DOI":"10.18764\/2178-2229.v20n2p64-67","article-title":"Doen\u00e7a de Jorge Lobo: Primeiro caso registrado no Estado do Maranh\u00e3o","volume":"20","author":"Silva","year":"2013","journal-title":"Cad. Pesqui."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"851","DOI":"10.2147\/TCRM.S46251","article-title":"Lobomycosis: Epidemiology, clinical presentation, and management options","volume":"10","author":"Francesconi","year":"2014","journal-title":"Ther. Clin. Risk Manag."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1590\/S0036-46652010000500010","article-title":"Ten years\u2019 experience with Jorge Lobo\u2019s disease in the state of Acre, Amazon region, Brazil","volume":"52","author":"Woods","year":"2010","journal-title":"Rev. Inst. Med. Trop. S\u00e3o Paulo"},{"key":"ref_11","unstructured":"Floriano, M.C. (2014). Doen\u00e7a de Jorge Lobo Entre os \u00cdndios Caiabu: Epidemiologia, An\u00e1lise Histopatol\u00f3gica e Imuno-Histoqu\u00edmica e Imuno-Histoqu\u00edmica Nas Diferentes Apresenta\u00e7\u00f5es Cl\u00ednicas. [Ph.D. Thesis, Universidade Federal de S\u00e3o Paulo]."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/BF02051697","article-title":"The reservoir area of lobomycosis. Comments on the work of Dr Carlos Pe\u00f1a on 2 Colombian cases","volume":"37","author":"Borelli","year":"1969","journal-title":"Mycopathol. Mycol. Appl."},{"key":"ref_13","first-page":"223","article-title":"Blastomycosis in the Amazon Valley (keloidian and South American)","volume":"38","author":"Guimaraes","year":"1950","journal-title":"Hosp. (Rio J.)"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1111\/j.1365-4362.1993.tb01466.x","article-title":"Lobomycosis","volume":"32","year":"1993","journal-title":"Int. J. Dermatol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/S0001-7310(09)73173-4","article-title":"Lobomycosis. Literature review and future perspectives","volume":"100","year":"2009","journal-title":"Actas Dermo-Sifiliogr."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.jaad.2004.10.883","article-title":"Tropical dermatology: Fungal tropical diseases","volume":"53","author":"Lupi","year":"2005","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1111\/j.1365-4632.2007.02937.x","article-title":"Lobomycosis in Venezuela","volume":"46","author":"Jaimes","year":"2007","journal-title":"Int. J. Dermatol."},{"key":"ref_18","first-page":"241","article-title":"Lobomycosis: A mycosis seldom observed in metropolitan France","volume":"20","author":"Maccari","year":"2000","journal-title":"Ann. Pathol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.4269\/ajtmh.17-0446","article-title":"Molecular confirmation of lobomycosis in an Italian traveler acquires in the Amazon Region of Venezuela","volume":"97","author":"Beltrame","year":"2017","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_20","first-page":"36","article-title":"Jorge Lobo blastomycosis","volume":"31","author":"Fialho","year":"1950","journal-title":"Folha Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1128\/JCM.38.3.1283-1285.2000","article-title":"Report of the first human case of Lobomycosis in United States","volume":"38","author":"Burns","year":"2000","journal-title":"J. Clin. Microb."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"715","DOI":"10.3201\/eid1004.030416","article-title":"Human case of lobomycosis","volume":"10","author":"Elsayed","year":"2004","journal-title":"Emerg. Infect. Dis."},{"key":"ref_23","first-page":"231","article-title":"Lobomycosis in African patients","volume":"159","author":"Husain","year":"2008","journal-title":"Br. J. Dermatol."},{"key":"ref_24","first-page":"581","article-title":"Inocula\u00e7\u00f5es em hamsters da blastomicose sul-americana (doen\u00e7a de Lutz), da blastomicose queloidiforme (doen\u00e7a de Lobo) e da blastomicose dos \u00edndios do Tapaj\u00f3s-Xingu","volume":"66","year":"1964","journal-title":"Hosp. (Rio J.)"},{"key":"ref_25","first-page":"135","article-title":"Ocorr\u00eancia de blastomicose queloidiana entre \u00edndios Caiabi","volume":"9","author":"Baruzzi","year":"1967","journal-title":"Rev. Inst. Med. Trop. S\u00e3o Paulo"},{"key":"ref_26","first-page":"60","article-title":"Piraip, a falsa lepra dos Caiabis","volume":"34","author":"Machado","year":"1966","journal-title":"Rev. Bras. Leprol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/j.1365-4362.1973.tb00011.x","article-title":"Occurrence of Lobo\u2019s blastomycosis among \u201cCaiabi\u201d brazilian Indians","volume":"12","author":"Baruzzi","year":"1973","journal-title":"Int. J. Dermatol."},{"key":"ref_28","first-page":"13","article-title":"Jorge Lobo\u2019s disease (keloidal blastomycosis) and tinea imbricata in Indians from the Xingu National Park, Central Brazil","volume":"12","author":"Baruzzi","year":"1982","journal-title":"Trop. Dr."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1365-4362.1989.tb02459.x","article-title":"Squamous-cell carcinoma and lobomycosis (Jorge Lobo\u2019s disease)","volume":"28","author":"Baruzzi","year":"1989","journal-title":"Int. J. Dermatol."},{"key":"ref_30","unstructured":"Veronesi, R., and Focaccia, R. (1996). Doen\u00e7a de Jorge Lobo. Tratado de Infectologia, Atheneu."},{"key":"ref_31","unstructured":"Collier, L., Balows, A., and Sussman, M. (1998). Loboa loboi. Topley and Wilson\u2019s Microbiology and Microbial Infections, Oxford University Press."},{"key":"ref_32","first-page":"135","article-title":"Lobomicose: Relato de 40 casos novos","volume":"74","author":"Opromolla","year":"1999","journal-title":"An. Bras. Dermatol."},{"key":"ref_33","unstructured":"Lacaz, C.S., Porto, E., Martins, J.E.C., Heins-Vaccari, E.M., and Melo, N.T. (2002). Tratado de Micologia M\u00e9dica, Savier. [9th ed.]."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1590\/abd1806-4841.20187044","article-title":"Lobomycosis: A therapeutic challenge","volume":"93","author":"Santos","year":"2018","journal-title":"An. Bras. Dermatol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"654","DOI":"10.3201\/eid2504.181403","article-title":"Lobomycosis in soldiers, Colombia","volume":"25","author":"Arenas","year":"2019","journal-title":"Emerg. Infect. Dis."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1007\/s11046-020-00464-7","article-title":"Lacaziosis (lobomycosis) from Southern Mexico: A case confirmed by molecular biology","volume":"185","author":"Bonifaz","year":"2020","journal-title":"Mycopathologia"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3315\/jdcr.2012.1104","article-title":"Lobomycosis: A case from Southeastern Europe and review of the literature","volume":"6","author":"Papadavid","year":"2012","journal-title":"J. Dermatol. Case Rep."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"930","DOI":"10.3201\/eid2605.190958","article-title":"Epidemiologic and clinical progression of lobomycosis among Kaiabi Indians, Brazil, 1965\u20132019","volume":"26","author":"Florian","year":"2020","journal-title":"Emerg. Infect. Dis."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.abd.2019.07.008","article-title":"What is your diagnosis? Keloidal cord-like lesion on the leg","volume":"95","author":"Oliveira","year":"2020","journal-title":"An. Bras. Dermatol."},{"key":"ref_40","unstructured":"Gon\u00e7alves, F.G. (Servi\u00e7o Estadual de Dermatologia do Acre, Programa Estadual de Dermatologia do Acre, Programa Estadual de Controle da Hansen\u00edase, SESACRE\/FUNDHACRE, Rio Branco, Acre, Brazil). Personal communication, 2022."},{"key":"ref_41","first-page":"578","article-title":"Lobos disease in an Atlantic bottle-nosed dolphin","volume":"159","author":"Migaki","year":"1971","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"105","DOI":"10.4269\/ajtmh.1975.24.105","article-title":"Lobomycosis as a disease of the Atlantic bottlenosed dolphin (Tursiops truncatus Montagu, 1821)","volume":"24","author":"Caldwell","year":"1975","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_43","first-page":"89","article-title":"Lobo\u2019s disease in Surinam patients","volume":"17","author":"Wiersema","year":"1965","journal-title":"Trop. Geogr. Med."},{"key":"ref_44","first-page":"26","article-title":"A case of Lobo\u2019s disease in the dolphin Sotalia guianensis","volume":"1","author":"Laarman","year":"1973","journal-title":"Aquat. Mamm."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.jaad.2006.06.020","article-title":"Dolphin-to-human transmission of lobomycosis","volume":"55","author":"Norton","year":"2006","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/1752-1947-3-67","article-title":"Accidental Jorge Lobo\u2019s disease in a worker dealing with Lacazia loboi infected mice: A case report","volume":"3","author":"Rosa","year":"2009","journal-title":"J. Med. Case Rep."},{"key":"ref_47","unstructured":"Moreno, I.B., Ott, P.H., Tavares, M., Oliveira, L.R., Borba, M.R., Driemeier, D., Nakashima, S.B., Heinzelmann, L.S., Siciliano, S., and Van Bressen, M.F. (2008, January 23\u201326). Mycotic dermatitis in common bottlenose Dolphins (Tursiops truncatus) from Southern Brazil, with confirmed record of lobomycosis disease. Proceedings of the Annual Meeting of the International Whaling Commission (IWC), IWC Scientific Committee, Santiago, Chile. Paper SC\/60\/DW1."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"672","DOI":"10.3201\/eid1504.080955","article-title":"Lobomycosis in inshore and estuarine dolphins","volume":"15","year":"2009","journal-title":"Emerg. Infect. Dis."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"104","DOI":"10.2460\/javma.228.1.104","article-title":"Lobomycosis in Atlantic bottlenose dolphins from the Indian River Lagoon, Florida","volume":"228","author":"Reif","year":"2006","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s10393-008-0187-8","article-title":"Lobomycosis in bottlenose dolphins (Tursiops truncatus) from the Indian River Lagoon, Florida: Estimation of prevalence, temporal trends, and spatial distribution","volume":"5","author":"Murdoch","year":"2008","journal-title":"EcoHealth"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"849","DOI":"10.7589\/0090-3558-45.3.849","article-title":"Lacaziosis in bottlenose dolphins (Tursiops truncatus) in the Indian River Lagoon, Florida, USA","volume":"45","author":"Durden","year":"2009","journal-title":"J. Wildl. Dis."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.marenvres.2008.11.002","article-title":"Skin diseases in Guiana dolphins (Sotalia guianensis) from the Paranagu\u00e1 estuary, Brazil: A possible indicator of a compromised marine environment","volume":"67","author":"Bressem","year":"2009","journal-title":"Mar. Environ. Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"151","DOI":"10.3354\/dao02037","article-title":"Lobomycosis-like disease and other skin conditions in Indo-Pacific bottlenose dolphins Tursiops aduncus from the Indian Ocean","volume":"84","author":"Kiszka","year":"2009","journal-title":"Dis. Aquat. Org."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1111\/j.1439-0507.2012.02184.x","article-title":"Lobomycosis: An emerging disease in humans and delphinidae","volume":"55","author":"Talhari","year":"2012","journal-title":"Mycoses"},{"key":"ref_55","unstructured":"Zaitz, C., Campbell, I., Marques, A.S., Ruiz, L.R.B., and Framil, V.M.S. (2012). Lacaziose (Doen\u00e7a de Jorge Lobo). Comp\u00eandio de Micologia M\u00e9dica, Editora Guanabara Koogan. [2nd ed.]."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"173","DOI":"10.3354\/dao02692","article-title":"Lacaziosis-like disease among bottlenose dolphins Tursiops truncatus photographed in Golf Dulce, Costa Rica","volume":"107","author":"Bessesen","year":"2014","journal-title":"Dis. Aquat. Org."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3354\/dao03206","article-title":"Lobomycosis-like disease in common bottlenose dolphins Tursiops truncatus from Belize and Mexico: Bridging the gap between the Americas","volume":"128","author":"Ramos","year":"2018","journal-title":"Dis. Aquat. Org."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"588","DOI":"10.3201\/eid1504.081358","article-title":"Lobomycosis in offshore bottlenose dolphins (Tursiops truncatus), North Carolina","volume":"15","author":"Rotstein","year":"2009","journal-title":"Emerg. Infect. Dis."},{"key":"ref_59","first-page":"392","article-title":"Entre le Yucatan, la Floride et la Guyane Fran\u00e7aise, la lobomycose existe-t-elle aux Antilles","volume":"77","author":"Pradinaud","year":"1984","journal-title":"Bull. Soci\u00e9t\u00e9 Pathol. Exot."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"3657","DOI":"10.1128\/JCM.43.8.3657-3661.2005","article-title":"Molecular model for studying the uncultivated fungal pathogen Lacazia loboi","volume":"43","author":"Vilela","year":"2005","journal-title":"J. Clin. Microbiol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1590\/S0365-05962013000200024","article-title":"Lobomycosis and squamous cell carcinoma","volume":"88","author":"Nogueira","year":"2013","journal-title":"An. Bras. Dermatol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.diagmicrobio.2005.02.008","article-title":"Vinyl adhesive tape effective for direct microscopy diagnosis of chromomycosis, lobomycosis, and paracoccidiodomycosis","volume":"52","author":"Miranda","year":"2005","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"ref_63","first-page":"425","article-title":"Correla\u00e7\u00e3o cl\u00ednico-patol\u00f3gica em 40 casos novos de lobomicose","volume":"75","author":"Opromolla","year":"2000","journal-title":"An. Bras. Dermatol."},{"key":"ref_64","first-page":"245","article-title":"Blastomicosis queloidiana o enfermidad de Jorge Lobo","volume":"2","author":"Reyes","year":"1960","journal-title":"Dermatol. Venez."},{"key":"ref_65","first-page":"29","article-title":"La blastomycose ch\u00e9loidienne ou maladie de Jorge Lobo en Guyane Fran\u00e7aise","volume":"56","author":"Silverie","year":"1963","journal-title":"Bull. Soci\u00e9t\u00e9 Pathol. Exot."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1111\/j.1365-4362.1980.tb03740.x","article-title":"Treatment of paracoccidioidomycosis, candidiasis, chromomycosis, lobomycosis and mycetoma with ketoconazole","volume":"19","author":"Wroclawski","year":"1980","journal-title":"Int. J. Dermatol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"162","DOI":"10.4269\/ajtmh.1986.35.162","article-title":"Lobomycosis in Western Brazil: Report of a clinical trial with ketoconazole","volume":"35","author":"Lawrence","year":"1986","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1007\/s00105-002-0351-y","article-title":"Successful treatment with clofazimine and itraconazole in a 46-year-old patient after 32 years duration of disease","volume":"53","author":"Fischer","year":"2002","journal-title":"Hautarzt"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.clindermatol.2011.09.014","article-title":"Lobomycosis","volume":"30","author":"Talhari","year":"2012","journal-title":"Clin. Dermatol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.4269\/ajtmh.12-0428","article-title":"Lobomycosis successfully treated with posaconazole","volume":"88","author":"Bustamante","year":"2013","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"634","DOI":"10.4269\/ajtmh.20-0090","article-title":"Multidrug therapy for leprosy can cure patientes with lobomycosis in Acre State, Brazil: A proof of therapy study","volume":"104","author":"Rosa","year":"2021","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"101576","DOI":"10.1016\/j.bjid.2021.101576","article-title":"Posaconazole for lobomycosis","volume":"25","author":"Pasqualotto","year":"2021","journal-title":"Braz. J. Infect. 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